Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells treated with aminophenylnorharman formed by norharman with aniline

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 515, Issue 1-2, 2002, Pages 181-188

  Ohe, Takeshi ^a   Takata, Tomoko ^a   Maeda, Yoko ^a   Totsuka, Yukari ^b   Hada, Noriyasu ^c   Matsuoka, Atsuko ^d   Tanaka, Noriho ^e   Wakabayashi, Keiji ^b  

^a KYOTO WOMEN'S UNIVERSITY   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c KEIO UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^e HATANO RESEARCH INSTITUTE   (Japan)

Author keywords

Amino 3 methylphenylnorharman; Aminophenylharman; Aminophenylnorharman; Chinese hamster lung (CHL) cells; Chromosome aberrations; Sister chromatid exchanges (SCEs)

Indexed keywords

1,8 DINITROPYRENE; AMINOPHENYLNORHARMAN; ANILINE; BETA CARBOLINE DERIVATIVE; CLASTOGEN; DACTINOMYCIN; MITOMYCIN C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BACTERIAL STRAIN; CALCULATION; CHINESE HAMSTER; CHROMOSOME ABERRATION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; EVALUATION; GENOTOXICITY; HAZARD; IN VITRO STUDY; INCUBATION TIME; LINEAR REGRESSION ANALYSIS; MAMMAL; MEDICAL LITERATURE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; RAT; REGULATORY MECHANISM; SISTER CHROMATID EXCHANGE;

ANILINE COMPOUNDS; ANIMALS; CARCINOGENS; CELL LINE; CHROMOSOME ABERRATIONS; CRICETINAE; CRICETULUS; DNA ADDUCTS; HARMINE; INDOLES; LUNG; MITOMYCINS; MUTAGENS; PYRIDINES; SALMONELLA TYPHIMURIUM; SISTER CHROMATID EXCHANGE;

CRICETINAE; CRICETULUS GRISEUS; MAMMALIA; SALMONELLA TYPHIMURIUM;

EID: 0037170701     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(02)00015-3     Document Type: Article

References (34)

1. Demonstration of mutagenicity of aniline and o-toluidine by norharman
2. Metabolic aspects of the comutagenic action of norharman
3. A new concept of co-mutagenicity from a phenomenon forgotten for the past two decades: Is it more important than previously expected?
4. Formation of DNA adducts by the co-mutagen norhaman with aromatic amines
5. Determination of β-carbolines in foodstuffs by high-performance liquid chromatography and high-performance liquid chromatography-mass spectrometry
6. Heterocyclic aromaic amine formation in grilled bacon, beef and fish and in grill scrapings
7. Human exposure to mutagenic/carcinogenic heterocyclic amines and comutagenic β-carbolines
8. Genotoxic potential of β-carbolines: A review
9. Quantification of the co-mutagenic β-carbolines, norharman and harman, in cigarette smoke condensates and cooked foods
10. Primary and secondary amines in the human environment
11. Analysis of lung air from patients with bronchogenic carcinoma and controls using gas-chromatography-mass spectrometry
12. Primary aromatic amines from side-stream cigarette smoke are common contaminants of indoor air
13. Norharman and harman in human urine
14. Identification and quantitative determination of aniline and toluidine in human urine
15. Detection of monocyclic aromatic amines, possible mammary carcinogens, in human milk
16. Structural determinaion of a mutagenic aminophenylnorharman produced by the co-mutagen norharman with aniline
17. Structures of mutagens produced by the co-mutagen norharman with o- and m-toluidine isomers
18. New Giemsa method for the differential staining of sister chromatids
19. A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures
20. Sister-chromatid exchanges: A report of the Gene-Tox program
21. Sister-chromatid exchange: Second report of the Gene-Tox program
22. Chromosome tests with 134 compounds on Chinese hamster cells in vitro-a screening for chemical carcinogens
23. A comparison of chromosome aberration induction by 25 compounds tested by two Chinese hamster cell (CHL and CHO) system in culture
24. Relationships between the DNA adducts and the mutations and sister-chromatid exchanges produced in Chinese hamster ovary cells by N-hydroxy-2-aminofluorene, N-hydroxy-N'-acetylbenzidine and 1-nitrosopyrene
25. Mechanisms for induction of mutations and chromosome alterations
26. Oxidative DNA damage by an N-hydroxy metabolite of the mutagenic compound formed from norharman and aniline
27. Induction of liver preneoplastic lesions by aminophenylnorharman, formed from norharman and aniline, in male F344 rats
28. Mutagenicity and carcinogenicity of nitroarenes and their sources in the environment