An additional 2′-ribofuranose residue at a specific position of the DNA primer prevents its elongation by HIV-1 reverse transcriptase

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 4, 2002, Pages 681-684

  Andreeva, O I ^a   Golubeva, A S ^a   Kochetkov, S N ^a   Van Aerschot, A ^b   Herdewijn, P ^b   Efimtseva, E V ^a   Ermolinsky, B S ^a   Mikhailov, S N ^a  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2' O BETA DEXTRO RIBOFURANOSYLADENOSINE; NUCLEOSIDE DERIVATIVE; OLIGODEOXYNUCLEOTIDE DERIVATIVE; PRIMER DNA; RNA; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; OLIGONUCLEOTIDE; RIBOSE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DNA SYNTHESIS; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; VIRUS REPLICATION; CHEMICAL STRUCTURE; CHEMISTRY; DNA REPLICATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVE SITE; HUMAN; KINETICS; METABOLISM; STRUCTURE ACTIVITY RELATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

CATALYTIC DOMAIN; DNA PRIMERS; DNA REPLICATION; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; KINETICS; MODELS, MOLECULAR; OLIGONUCLEOTIDES; RIBOSE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037170035     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00836-8     Document Type: Article

References (20)