Effects of extracellular Ca2+ influx on endothelin-1-induced intracellular mitogenic cascades in C6 glioma cells

European Journal of Pharmacology

Volumn 435, Issue 2-3, 2002, Pages 119-123

  Kawanabe, Yoshifumi ^a   Hashimoto, Nobuo ^a   Masaki, Tomoh ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Ca2+ influx; Endothelin; Extracellular signal regulated kinase; Mitogenesis

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 (3,4 DIHYDRO 6,7 DIMETHOXY 1 ISOQUINOLINYL) 2 PHENYL N,N BIS[2 (2,3,4 TRIMETHOXYPHENYL)ETHYL]ACETAMIDE; CALCIUM CHANNEL; CALCIUM ION; ENDOTHELIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; 1 (2 (3 (4 METHOXYPHENYL)PROPOXY) 4 METHOXYPHENYLETHYL) 1H IMIDAZOLE; 1-(2-(3-(4-METHOXYPHENYL)PROPOXY)-4-METHOXYPHENYLETHYL)-1H-IMIDAZOLE; ACETAMIDE DERIVATIVE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; DNA; ENZYME INHIBITOR; FLAVONOID; IMIDAZOLE DERIVATIVE; ISOQUINOLINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGENIC AGENT; THYMIDINE; TRITIUM;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME REPRESSION; GLIOMA CELL; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; BRAIN TUMOR; CELL CULTURE; DRUG ANTAGONISM; DRUG INTERACTION; GLIOMA; METABOLISM; PATHOLOGY; RAT;

ACETAMIDES; ANIMALS; BRAIN NEOPLASMS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; DNA; DRUG INTERACTIONS; ENDOTHELIN-1; ENZYME INHIBITORS; FLAVONOIDS; GLIOMA; IMIDAZOLES; ISOQUINOLINES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MITOGENS; RATS; THYMIDINE; TRITIUM; TUMOR CELLS, CULTURED;

EID: 0037168868     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01492-3     Document Type: Article

References (12)

1. Calcium influx activates extracellular-regulated kinase/mitogen-activated protein kinase pathway through a calmodulin-sensitive mechanism in PC12 cells
2. Endothelin-mediated vascular growth requires p42/p44 mitogen-activated protein kinase and p70 S6 kinase cascades via transactivation of epidermal growth factor receptor
3. 2+ influx through nonselective cation channels plays an essential role in endothelin-1-induced mitogenesis in C6 glioma cells
4. 2+ influx on endothelin-1-induced mitogenesis
5. Endothelin-1 stimulates c-fos mRNA expression in C6 glioma cells via MAP kinase pathway
6. Stimulation by endothelin-1 of mitogen-activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells
7. Stimulation of C2C12 myoblast growth by basic fibroblast growth factor and insulin-like growth factor 1 can occur via mitogen-activated protein kinase-dependent and -independent pathways
8. Calcium-mediated endothelin signaling in C6 glioma cells
9. Λ: The role of a wortmannin-sensitive signaling pathway
10. Molecular mechanisms of endothelin-1-induced cell-cycle progression: Involvement of extracellular signal-regulated kinase, protein kinase C, and phosphatidylinositol 3-kinase at distinct points
11. Ca(2+)-dependent stimulation of retinoblastoma gene product phosphorylation and p34cdc2 kinase activation in serum-stimulated human fibroblasts
12. The retinoblastoma protein and cell cycle control