메뉴 건너뛰기




Volumn 4, Issue 2, 2002, Pages 265-267

An aldol-based approach to the synthesis of the antibiotic anisomycin

Author keywords

[No Author keywords available]

Indexed keywords

3-HYDROXYBUTANAL; ALDEHYDE; ALDOL; ANISOMYCIN; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; GLYCOLIC ACID; GLYCOLIC ACID DERIVATIVE;

EID: 0037165329     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol017016u     Document Type: Article
Times cited : (46)

References (40)
  • 6
    • 0034680091 scopus 로고    scopus 로고
    • For a recent example of its use, see: (a) Dudai, Y. Nature 2000, 406, 686. (b) Nader, K.; Schafe, G. E.; Le Doux, J. E. Nature 2000, 406, 722.
    • (2000) Nature , vol.406 , pp. 686
    • Dudai, Y.1
  • 7
    • 0034680134 scopus 로고    scopus 로고
    • For a recent example of its use, see: (a) Dudai, Y. Nature 2000, 406, 686. (b) Nader, K.; Schafe, G. E.; Le Doux, J. E. Nature 2000, 406, 722.
    • (2000) Nature , vol.406 , pp. 722
    • Nader, K.1    Schafe, G.E.2    Le Doux, J.E.3
  • 34
    • 0000763561 scopus 로고    scopus 로고
    • For a recent review on the role of α-dibenzylamino aldehydes in synthesis, see: Reetz, M. T. Chem. Rev. 1999, 99, 1121.
    • (1999) Chem. Rev. , vol.99 , pp. 1121
    • Reetz, M.T.1
  • 35
    • 11244342445 scopus 로고    scopus 로고
    • 3 was shown to be of crucial importance in maintaining the stereochemical integrity of the α-amino ester
    • 3 was shown to be of crucial importance in maintaining the stereochemical integrity of the α-amino ester.
  • 36
    • 11244292871 scopus 로고    scopus 로고
    • A full analysis of the results of this and other related glycolate aldol reactions will be reported in a separate communication
    • A full analysis of the results of this and other related glycolate aldol reactions will be reported in a separate communication.
  • 38
    • 11244298099 scopus 로고    scopus 로고
    • note
    • A synthetic route involving selective mono-N-debenzylation of the aldol adduct 7, cyclization to a protected pyrrolidin-2-one, and then reduction to the protected pyrrolidine 10 was not pursued, as in practice it was found to be most convenient to carry out the aldol coupling and reduction to alcohol 8 without purification of the intermediate aldol adduct 7.
  • 39
    • 11244295173 scopus 로고    scopus 로고
    • The Evans oxazolidinone was also recovered in reasonable yield (60%)
    • The Evans oxazolidinone was also recovered in reasonable yield (60%).
  • 40
    • 0344699370 scopus 로고    scopus 로고
    • Similar mesylate-induced cyclizations have been observed in the synthesis of N-(3-pyrrolodinylmethyl)benzamides: Thomas, C.; Hübner, H.; Gmeiner, P. Bioorg. Med. Chem. Lett. 1999, 9, 841.
    • (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 841
    • Thomas, C.1    Hübner, H.2    Gmeiner, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.