Transgenic mice expressing human copper-zinc superoxide dismutase exhibit attenuated apparent diffusion coefficient reduction during reperfusion following focal cerebral ischemia

Brain Research

Volumn 947, Issue 1, 2002, Pages 1-8

  Kokubo, Yasuaki ^a   Matson, Gerald B ^b   Derugin, Nikita ^a   Hill, Tony ^a,b   Mancuso, Anthony ^c   Chan, Pak H ^d   Weinstein, Philip R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Stroke

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; HEAT SHOCK PROTEIN; MESSENGER RNA; PROTEIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN MAPPING; BRAIN PROTECTION; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DIFFUSION WEIGHTED IMAGING; GENE EXPRESSION; HEMISPHERE; IN SITU HYBRIDIZATION; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NISSL STAINING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REPERFUSION; RNA ANALYSIS; TIME; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; BRAIN ISCHEMIA; BRAIN MAPPING; CEREBRAL INFARCTION; COLORING AGENTS; DIFFUSION; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IN SITU HYBRIDIZATION; MAGNETIC RESONANCE IMAGING; MICE; MICE, TRANSGENIC; MIDDLE CEREBRAL ARTERY; REPERFUSION INJURY; RNA, MESSENGER; SUPEROXIDE DISMUTASE;

EID: 0037162969     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02899-8     Document Type: Article

References (46)

1. Role of superoxide dismutase in ischemic brain injury: Reduction of edema and infarction in transgenic mice following focal cerebral ischemia
2. Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia
3. Role of oxidants in ischemic brain damage
4. Transgenic mice with increased Cu/Zn-superoxide dismutase activity: Animal model of dosage effects in Down syndrome
5. A comparison of the early development of ischaemic damage following permanent middle cerebral artery occlusion in rats as assessed using magnetic resonance imaging and histology
6. The relationship between the apparent diffusion coefficient measured by magnetic resonance imaging, anoxic depolarization, and glutamate efflux during experimental cerebral ischemia
7. MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia
8. Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: The relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances
9. NMR imaging of the apparent diffusion coefficient (ADC) for the evaluation of metabolic suppression and recovery after prolonged cerebral ischemia
10. Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70
11. Temporal evolution and spatial distribution of the diffusion constant of water in rat brain after transient middle cerebral artery occlusion
12. Prolonged expression of hsp70 mRNA following transient focal cerebral ischemia in transgenic mice overexpressing CuZn-superoxide dismutase
13. Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging
14. Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase
15. Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the 'penumbra' following focal cerebral ischemia in the rat
16. Induction of 70-kDa heat shock protein and hsp70 mRNA following transient focal cerebral ischemia in the rat
17. Relationship between diffusion-weighted MR images, cerebral blood flow, and energy state in experimental brain infarction
18. Time-dependent diffusion of water in a biological model system
19. Neuroprotection with NBQX in rat focal cerebral ischemia. Effects on ADC probability distribution functions and diffusion-perfusion relationships
20. Correlation of early reduction in the apparent diffusion coefficient of water with blood flow reduction during middle cerebral artery occlusion in rats
21. Transient MRI-detected water apparent diffusion coefficient reduction correlates with c-fos mRNA but not hsp70 mRNA induction during focal cerebral ischemia in rats
22. An integrated program for amplitude-modulated RF pulse generation and remapping with shaped gradients
23. Development of methods for measurement of ischemic mouse brain apparent diffusion coefficient (ADC)
24. Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats
25. Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI
26. Comparison of diffusion- and T2-weighted MRI for the early detection of cerebral ischemia and reperfusion in rats
27. Selective vulnerability of hippocampal CA1 neurons cannot be explained in terms of an increase in glutamate concentration during ischemia in the gerbil: Brain microdialysis study
28. Early detection of ischemic injury: Comparison of spectroscopy, diffusion-, T2-, and magnetic susceptibility-weighted MRI in cats
29. Combined perfusion and diffusion-weighted magnetic resonance imaging in a rat model of reversible middle cerebral artery occlusion
30. Oxygen radicals in cerebral ischemia
31. Peri-infarct and remote excitability changes after transient middle cerebral artery occlusion
32. Relevance of interstitial glutamate to selective vulnerability in focal cerebral ischemia
33. Sensitivity of magnetic resonance diffusion-weighted imaging and regional relationship between the apparent diffusion coefficient and cerebral blood flow in rat focal cerebral ischemia
34. Mitochondria are selective targets for the protective effects of heat shock against oxidative injury
35. Electrophysiological transcortical diaschisis after middle cerebral artery occlusion (MCAO) in rats
36. Coexistence and gene expression of phenylethanolamine N-methyltransferase, tyrosine hydroxylase, and neuropeptide tyrosine in the rat and bovine adrenal gland: Effects of reserpine
37. Cerebral edema after temporary and permanent middle cerebral artery occlusion in the rat
38. Hyperacute stroke: Evaluation with combined multisection diffusion-weighted and hemodynamically weighted echo-planar MR imaging
39. A semiautomated method for measuring brain infarct volume
40. Theoretical model for water diffusion in tissues
41. Differential glutathione peroxidase mRNA upregulations in rat forebrain areas after transient hypoxia-ischemia
42. Diffusion- and perfusion-weighted MR imaging of transient focal cerebral ischaemia in mice
43. Fast magnetic resonance diffusion-weighted imaging of acute human stroke
44. Clinical outcome in ischemic stroke predicted by early diffusion-weighted and perfusion magnetic resonance imaging: A preliminary analysis
45. Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia
46. Neuronal nitric oxide synthase mutant mice show smaller infarcts and attenuated apparent diffusion coefficient changes in the peri-infarct zone during focal cerebral ischemia