Hammerhead ribozymes reduce central nervous system (CNS)-derived neuronal nitric oxide synthase messenger RNA in a human cell line

Neuroscience Letters

Volumn 329, Issue 1, 2002, Pages 81-85

  Maniotis, D ^a,c   Wood, M J A ^a   Phylactou, L A ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b CYPRUS INSTITUTE OF NEUROLOGY AND GENETICS   (Cyprus)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Adenoviral vectors; Central nervous system; Neuronal nitric oxide synthase; Nitric oxide; Ribozyme

Indexed keywords

ADENOVIRUS VECTOR; MESSENGER RNA; NITRIC OXIDE SYNTHASE; RIBOZYME; HAMMERHEAD RIBOZYME; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NOS1 PROTEIN, HUMAN;

ARTICLE; BRAIN NERVE CELL; CELL FREE SYSTEM; CELL LINE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENZYME DEGRADATION; GENE CONSTRUCT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUROBLASTOMA CELL; NUCLEIC ACID PROBE; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; ADENOVIRUS; CELL CULTURE; CONFORMATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; METABOLISM; MOLECULAR GENETICS; NEUROBLASTOMA; OXIDATIVE STRESS;

ADENOVIRIDAE; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC VECTORS; HUMAN; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; NITRIC OXIDE; NITRIC-OXIDE SYNTHASE; NUCLEIC ACID CONFORMATION; OXIDATIVE STRESS; PLASMIDS; RNA, CATALYTIC; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED; HUMANS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I;

EID: 0037162639     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)00582-7     Document Type: Article

References (26)

1. The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localisation
2. Role of divalent metal ions in the hammerhead RNA cleavage reaction
3. Nitric oxide synthase: Role as a transmitter/mediator in the brain and endocrine system
4. Gases as biological messengers: Nitric oxide and carbon monoxide in the brain
5. Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice
6. Ribozyme-mediated inhibition of caspase-3 protects cerebellar granule cells from apoptosis induced by serum-potassium deprivation
7. Kinetics of intermolecular cleavage by hammerhead ribozymes
8. Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase
9. Expression of two types of nitric oxide synthase mRNA in human neuroblastoma cell lines
10. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons
11. Influence of chromosomal position and copy number of a white-directed ribozyme gene on the suppression of eye pigmentation in Drosophila melanogaster
12. Macrophage cytotoxicity: Role for L-arginine deiminase and imino nitrogen oxidation to nitrite
13. Targeted disruption of the neuronal nitric oxide synthase gene
14. Retrovirally expressed anti-HIV ribozymes confer a selective survival advantage on CD4+ T cells in vitro
15. Efficient and specific ribozyme-mediated reduction of bovine alpha-lactalbumin expression in double transgenic mice
16. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
17. Excitatory amino acid neurotoxicity and neurodegenerative disease
18. In situ demonstration of inhibitory effects of hammerhead ribozymes that are targeted to the hepatitis Bx sequence in cultured cells
19. Hammerhead ribozymes targeted to the FBN1 mRNA can discriminate a single base mismatch between ribozyme and target
20. Dopamine D(2) receptor ribozyme inhibits quinpirole-induced stereotypy in rats
21. Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo
22. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice
23. Antisense technologies have a future fighting neurodegenerative diseases
24. Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide
25. Reduction of functional N-methyl-D-aspartate receptors in neurons by RNase P-mediated cleavage of the NR1 mRNA
26. Generating loss-of-function phenotypes of the fushi tarazu gene with a targeted ribozyme in Drosophila