Synthesis of collagen is dysregulated in cultured fibroblasts derived from skin of subjects with varicose veins as it is in venous smooth muscle cells

Circulation

Volumn 106, Issue 4, 2002, Pages 479-483

  Sansilvestri Morel, Patricia ^a   Rupin, Alain ^a   Jaisson, Stéphane ^a   Fabiani, Jean Noël ^a   Verbeuren, Tony J ^a   Vanhoutte, Paul M ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Collagen; Metalloproteinases; Remodeling; Veins

Indexed keywords

COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; COLLAGENASE 3; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRILYSIN; MESSENGER RNA; NEUTROPHIL COLLAGENASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ADULT; AGED; ARTICLE; CELL CULTURE; CLINICAL ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN; SMOOTH MUSCLE FIBER; VARICOSIS; VASCULAR SMOOTH MUSCLE; VEIN DILATATION;

AGED; CELL DIVISION; CELLS, CULTURED; COLLAGEN TYPE I; COLLAGEN TYPE III; CULTURE MEDIA; FEMALE; FIBRILLAR COLLAGENS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; KINETICS; MALE; MATRIX METALLOPROTEINASES; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; SKIN; TISSUE INHIBITOR OF METALLOPROTEINASES; VARICOSE VEINS; VEINS;

EID: 0037162375     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000022846.22923.46     Document Type: Article

References (27)

1. Venous wall function in the pathogenesis of varicose veins
2. Venous disease: From pathophysiology to quality of life
3. Analysis of the connective tissue matrix and proteolytic activity of primary varicose veins
4. Alterations of the extracellular matrix of venous walls in varicose veins
5. Collagen subtype pattern in normal and varicose saphenous veins in human
6. Abnormal deposition of extracellular matrix proteins by cultured smooth muscle cells from human varicose veins
7. Imbalance in the synthesis of collagen type I and collagen type III in smooth muscle cells derived from human varicose veins
8. The molecular and fibrillar structure of collagen and its relationship to the mechanical properties of connective tissue
9. Vascular smooth muscle αvβ3 integrin mediates arteriolar vasodilation in response to RGD peptides
10. Importance of the familial factor in varicose disease
11. Epidemiology of chronic venous insufficiency
12. Venous distensibility in patients with varicose veins
13. Lower limb venous dynamics in normal persons and children of patients with varicose veins
14. Simultaneous degradation of elastin in dermis and in aorta
15. Histomorphometric parameters and susceptibility to neutrophil elastase degradation of skin elastic fibres from healthy individuals and patients with Marfan syndrome, Ehlers-Danlos type IV and pseudoxanthoma elasticum
16. Measurement of the amount of elastic fibers in the skin and temporal arteries of healthy aged individuals by automated image analysis
17. Skin is a window on heritable disorders of connective tissue
18. Single base mutation in the type III procollagen gene that converts the codon for glycine 883 to aspartate in a mild variant of Ehlers-Danlos syndrome IV
19. Ehlers Danlos syndrome type IV
20. Assessment of wall structure and composition of varicose veins with reference to collagen, elastin and smooth muscle content
21. Analysis of the ex vivo specificity of human gelatinase A and B towards skin collagen and elastic fibers by computerized morphometry
22. Human type III collagen gene expression is coordinately modulated with the type I collagen genes during fibroblasts growth
23. Synthesis of an altered type III procollagen in a patient with type IV Ehlers-Danlos syndrome
24. Venous ulcer fibroblasts compared with normal fibroblasts show differences in collagen but not fibronectin production under both normal and hypoxic conditions
25. Lipodermatosclerosis is characterized by elevated expression and activation of matrix metalloproteinases: Implications for venous ulcer formation
26. Biochemical analysis of dermal connective tissue in subjects affected by primary uncomplicated varicose veins