Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 8, 2002, Pages 1233-1235

  Dankwardt, Sharon M ^a   Abbot, Sarah C ^a   Broka, Chris A ^a   Martin, Robert L ^a   Chan, Christine S ^a   Springman, Eric B ^a,b   Van Wart, Harold E ^a,c   Walker, Keith A M ^a  

^a ROCHE BIOSCIENCE   (United States)

^b Locus Discovery Inc   (United States)

^c Metabolex   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; AMINO ACID DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; HYDROXAMIC ACID DERIVATIVE; PROCOLLAGEN C PROTEINASE; PROTEINASE INHIBITOR; SULFONAMIDE;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; PROCESS OPTIMIZATION; PROTEINASE INHIBITION; SOLID;

AMINO ACIDS; BONE MORPHOGENETIC PROTEINS; HYDROXAMIC ACIDS; METALLOENDOPEPTIDASES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0037156344     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00117-8     Document Type: Article

References (11)