Novel bicyclic lactam inhibitors of thrombin: Highly potent and selective inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 8, 2002, Pages 1181-1184

  St Denis, Yves ^a   Leévesque, Sophie ^a   Bachand, Benoit ^a   Edmunds, Jeremy J ^b   Leblond, Lorraine ^a   Preéville, Patrice ^a   Tarazi, Micheline ^a   Winocour, Peter D ^a   Siddiqui, M Arshad ^a  

^a Shire Canada   (Canada)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTAM; SULFONAMIDE; THROMBIN INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; IN VIVO STUDY; MOLECULAR WEIGHT; NONHUMAN; RAT;

ANTITHROMBINS; LACTAMS;

EID: 0037156333     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00131-2     Document Type: Article

References (12)