Solution structure and dynamics of the central CCP module pair of a poxvirus complement control protein

Journal of Molecular Biology

Volumn 307, Issue 1, 2001, Pages 323-339

  Henderson, Colin E ^a   Bromek, Krystyna ^a   Mullin, Nicholas P ^a   Smith, Brian O ^a   Uhrín, Dušan ^a   Barlow, Paul N ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Complement; Modules; NMR; Protein structure; Vaccinia virus

Indexed keywords

COMPLEMENT CONTROL PROTEIN; COMPLEMENT REGULATORY PROTEIN; NITROGEN 15; REGULATOR PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANISOTROPY; ARTICLE; BINDING SITE; CALCULATION; COMPLEMENT ACTIVATION; COMPLEMENT INHIBITION; CONTROLLED STUDY; DIFFUSION; HYDRODYNAMICS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MUTAGENESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; POXVIRUS; PRIORITY JOURNAL; PROTEIN STRUCTURE; SMALLPOX VIRUS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VACCINIA VIRUS;

POXVIRIDAE; VACCINIA; VACCINIA VIRUS; VARIOLA;

EID: 0035896016     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4477     Document Type: Article

References (66)

1. 15N relaxation using inverse detected two dimensionsal NMR spectroscopy: The central helix is flexible
2. Strategy for studying modular proteins: Application to complement modules
3. Secondary structure of a complement control protein module by two-dimensional NMR
4. Solution structure of the fifth repeat of factor H: A second example of the complement control protein module
5. Solution structure of a pair of complement modules by nuclear magnetic resonance
6. Protein modules
7. Structure and distribution of modules in extracellular proteins
8. Adhesion mechanism of human β2-glycoprotein I to phospholipids based on its crystal structure
9. Building protein structure and function from modular units
10. NMR ofmodular proteins
11. Crystal structure of two CD46 domains reveals an extended measles virus-binding surface
12. Solution structure and dynamics of linked cell attachment modules of mouse fibronectin containing the RGD and synergy regions: Comparison with the human fibronectin crystal structure
13. Evolutionary mobile modules in proteins
14. Efficient analysis of macromolecular rotational diffusion from heteronuclear relaxation data
15. 15N NMR relaxation
16. Crystal structure of the catalytic domain of human complement C1 s: A serine protease with a handle
17. 2O in protein NMR. Application to sensitivity enhancement and NOE measurement
18. B receptor 1a
19. On the classification and evolution of protein modules
20. On the classification of modular proteins
21. Water suppression that works - Excitation sculpting using arbitrary wave-forms and pulsed-field gradients
22. Vaccinia virus complement control protein prevents antibody-dependant neutralization of infectivity and contributes to virulence
23. Investigation of exchange processes by two-dimensional NMR spectroscopy
24. 2 values in proteins
25. Independently melting modules and highly structured intermodular junctions within complement receptor type 1
26. Central modules of the Vaccinia virus complement control protein are not in extensive contact
27. Co-operativity between modules within a C3b-binding site of complement receptor type 1
28. Combining ultracentrifugation with fluorescence to follow the unfolding of modules 16-17 of complement receptor type 1
29. Poxviral mimicry of complement and chemokine synthesis components: What's the end game?
30. Vaccinia virus encodes a secretory polypeptide structurally related to complement control proteins
31. Inhibition of the complement cascade by the major secretory protein of the Vaccinia virus
32. 1H and 2D NMR spectra by interactive computer-graphics
33. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
34. 15N separated NOE data: A novel real-space and ab initio approach
35. Measurement of H-N-H-alpha couplings in calcium free calmodulin using new 2D and 3D water flipback methods
36. 2.0 Angstrom crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region
37. Model: Free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. & 2
38. Backbone dynamics of Escherichia coli ribonuclease HI: Correlations with structure and function in an active enzyme
39. Rapid recording of 2D NMR-spectra without phase cycling: Application to the study of hydrogen-exchange in proteins
40. Improved sensitivity of HSQC spectra of exchanging protons at short interscan dalays using a new fast HSQC (FHSQC) detection scheme that avoids water saturation
41. Structures of the extracellular domain of the type I tumour necrosis factor receptor
42. Automated NOESY interpretation with ambiguous distance restraints: The refined NMR solution structure of the plekstrin homology domain from beta-spectrin
43. The three-dimensional structure of a complement control protein module in solution
44. Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions
45. Improved techniques for homonuclear rotating-frame and isotropic mixing experiments
46. Structure-function relationships of the complement components
47. Complement-system proteins which interact with C3b or C4b: A superfamily of structurally related proteins
48. Creation and functional characterisation of spice, the small pox inhibitor of complement enzymes
49. Functional characterisation of soluble and membrane-bound forms of vaccinia virus complement control protein (VCP)
50. Broad-band homonuclear cross polarisation in 2D NMR using DIPSI-2
51. 2-glycoprotein I: Implications for phospholipid binding and the antiphospholipid syndrome
52. Computer-optimised decoupling scheme for wideband applications and low-level operation
53. 15N HSQC experiments optimised to retain full sensitivity
54. Interface characterisation of the type II pair from fibronectin
55. Conserved surface exposed K/R-X-K/R motifs and net positive charge on poxvirus complement control proteins serve as putative heparin binding sites and contribute to inhibition of molecular interactions with human endothelial cells: A novel mechanism for evasion of host defence
56. Module-module interactions in the cell binding region of fibronectin: Stability, flexibility and specificity
57. Calculation of NMR relaxation, covolume, and scattering-related properties of bead models using the SOLPRO computer program
58. Frictional models for stochastic simulations of proteins
59. NMR studies of a viral protein that mimics the regulators of complement activation
60. The chemical shift index: A fast and simple method for the assignment of protein secondary structure through NMR spectroscopy
61. Nuclear spin relaxation in ellipsoids undergoing rotational Brownian motion