The pro-oxidant role of protein SH groups of hemoglobin in rat erythrocytes exposed to menadione

Chemico-Biological Interactions

Volumn 139, Issue 1, 2002, Pages 97-114

  Lusini, Lorenzo ^a   Rossi, Ranieri ^a   Giustarini, Daniela ^a   Simplicio, Paolo Di ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

Glutathione; Menadione; Oxidative stress; Protein arylation; Rat hemoglobin; Redox cycling

Indexed keywords

CARBON MONOXIDE; CYSTEINE DERIVATIVE; DISULFIDE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEME; HEMOGLOBIN; MENADIONE; METHEMOGLOBIN; NITROGEN; OXYGEN; PROTEIN; THIOL DERIVATIVE;

ANIMAL CELL; ARTICLE; BLOOD TOXICITY; CHEMICAL MODIFICATION; CONJUGATION; CONTROLLED STUDY; DEPLETION; ERYTHROCYTE; HEMOGLOBIN SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; NORMAL HUMAN; OXIDATION; OXYGEN CONSUMPTION; RAT; SPECIES COMPARISON;

ANIMALS; CARBON MONOXIDE; ERYTHROCYTES; HUMANS; METHEMOGLOBIN; OXYGEN; OXYGEN CONSUMPTION; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS; VITAMIN K 3;

EID: 0037154406     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(01)00296-4     Document Type: Article

References (49)

1. The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes
2. Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes
3. 2+ homeostasis
4. Alterations of surface morphology caused by the metabolism of menadione in mammalian cells are associated with the oxidation of critical sulfhydryl groups in cytoskeletal proteins
5. Fat-soluble vitamins. Vitamins A, K and E
6. Heinz body anemia and related phenomena
7. 3 and C in a patient with a defect in electron transport at complex III in skeletal muscle
8. Antimalarian quinones: Redox potential dependence of methemoglobin formation and heme release in erythrocytes
9. Mitomicin C and menadione for the treatment of advanced gastrointestinal cancers: A phase II trial
10. 3 and methotrexate in tumor-bearing animals
11. Phase I study of mitomycin C and menadione in advanced solid tumors
12. Free radical formation by antitumor quinones
13. Quinone chemistry and toxicity
14. Pro- and antioxidant functions of quinones and quinone reductases in mammalian cells
15. Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism
16. Molecular mechanisms of quinone cytotoxicity
17. Mutagenicity of quinones: Pathways of metabolic activation and detoxification
18. Production of superoxide anion during the oxidation of hemoglobin by menadione
19. Comparative toxicity of alkyl-1,4-naphthoquinones in rats: Relationship to free radical production in vitro
20. 2+-activated mechanisms in cell killing
21. 2+ in toxic cell killing
22. Autoxidation of naphthohydroquinones: Effects of metals, chelating agents and superoxide dismutase
23. Formation and reduction of glutathione-protein mixed disulfides during oxidative stress - A study with isolated hepatocytes and menadione (2-methyl-1,4 naphthoquinone)
24. Hepatic low-level chemiluminescence during redox cycling of menadione and the menadione-glutathione conjugate: Relation to glutathione and NAD(P)H: Quinone reductase (DT diaphorase) activity
25. Formation of glutathione conjugated semiquinones by the reaction of quinones with glutathione: An ESR study
26. DT-diaphorase-catalysed reduction of 1,4-naphthoquinone derivatives and glutathionyl-quinone conjugates - Effect of substituents on autoxidation rates
27. The toxicity of menadione (2-methyl-1,4 naphthoquinone) and two thioether conjugates studied with isolated renal epithelial cells
28. Role of protein-SH groups in redox homeostasis - The erythrocyte as a model system
29. Generation of hydrogen peroxide in erythrocytes by hemolytic agents
30. Erythrocyte membrane interactions with menadione and the mechanism of menadione-induced hemolysis
31. Fast-reacting thiols in rat hemoglobins can intercept damaging species in erythrocytes more efficiently than glutathione
32. Different metabolizing ability of thiol reactants in human and rat blood. Biochemical and pharmacological implications
33. Thiol groups in proteins as endogenous reductants to determine glutathione-protein mixed disulphides in biological systems
34. Tissue sulfhydryl groups
35. The reaction of menadione with haemoglobin - Mechanism and effect of superoxide dismutase
36. Reactivity of thiols towards derivatives of 2- and 6-methyl-1,4-naphthoquinone bioreductive alkylating agents
37. Electrostatic influence of local cysteine environments on disulfide exchange kinetics
38. Endogenous catechol thioethers may be pro-oxidant or antioxidant
39. Hepatotoxicity of menadione predominates in oxygen-rich zones of the liver lobule
40. Oxygen dependent hepatotoxicity due to doxorubicin; role of reducing equivalent supply in perfused rat liver
41. Glutathionyl- and hydroxyl radical formation coupled to the redox transitions of 1,4-naphthoquinone bioreductive alkylating agents during glutathione two-electron reductive addition
42. Semiquinone anion radicals formed by the reaction of quinones with glutathione or amino acids
43. Effect of glutathione depletion on haemoglobin and membrane integrity of red blood cells of rats
44. The intracellular and membrane effects of oxidant agents on normal red cells
45. The relative importance of oxidative stress versus arylation in the mechanism of quinone-induced cytotoxicity to platelets
46. Minor thiols cysteine and cysteinylglycine regulate the competition between glutathione and protein SH groups in human platelets subjected to oxidative stress
47. The role of oxidative processes in the cytotoxicity of substituted 1,4-naphthoquinones in isolated hepatocytes
48. The biological significance of non-enzymatic reaction of menadione with plasma thiols: Enhancement of menadione-induced cytotoxicity to platelets by the presence of blood plasma