Preparation and characterization by morphological analysis of diclofenac/PEG 4000 granules obtained using three different techniques

International Journal of Pharmaceutics

Volumn 242, Issue 1-2, 2002, Pages 285-289

  Rodriguez, L ^a   Cavallari, C ^a   Passerini, N ^a   Albertini, B ^a   Gonzalez Rodriguez M L ^b   Fini, A ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Diclofenac; Image analysis; Polyethylene glycol 4000; Steam granulation; Wet granulation

Indexed keywords

DICLOFENAC; MACROGOL 400;

ARTICLE; CALORIMETRY; CRYSTAL STRUCTURE; DRUG GRANULE; DRUG RELEASE; DRUG SOLUBILITY; IMAGE ANALYSIS; IN VITRO STUDY; INTERMETHOD COMPARISON; LABORATORY; METHODOLOGY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STRUCTURE ANALYSIS; TIME; WATER VAPOR; X RAY POWDER DIFFRACTION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLOGRAPHY, X-RAY; DICLOFENAC; DRUG COMPOUNDING; IMAGE PROCESSING, COMPUTER-ASSISTED; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POWDERS; SOLUBILITY;

EID: 0037151577     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00189-8     Document Type: Article

References (7)

1. Fractal analysis of sodium cholate particles
2. Formation of ion-pairs in aqueous solution of diclofenac salts
3. Descriptors of irregular particle morphology and powder properties
4. Nucleation, growth and breakage phenomena in agitated wet granulation processes: A review
5. An investigation into the kinetics of liquid distribution and growth in high shear mixer agglomeration
6. Use of moist granulation technique (MGT) to develop controlled-release dosage forms of acethaminophen