Subchronic treatment with cyclosporin A decreases the binding properties of the GABAA receptor in ovariectomized rats

Life Sciences

Volumn 72, Issue 4-5, 2002, Pages 425-430

  Tominaga, Koji ^a   Kai, Mamiko ^a   Yamauchi, Atsushi ^a   Dohgu, Shinya ^a   Toda, Kayoko ^b   Oishi, Ryozo ^b   Kataoka, Yasufumi ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Aminobutyric acid (GABA); Climacterium; Cyclosporin A; GABAA receptor; Menopause; Ovariectomy

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CYCLOSPORIN A; ESTRADIOL; MUSCIMOL;

ANIMAL TISSUE; BINDING AFFINITY; BRAIN MEMBRANE; BRAIN SYNAPTOSOME; CLIMACTERIUM; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GABAERGIC TRANSMISSION; HIPPOCAMPUS; NONHUMAN; OVARIECTOMY; RAT; RECEPTOR BINDING;

ANIMALS; CYCLOSPORINE; DEPRESSION, CHEMICAL; ESTRADIOL; FEMALE; GABA AGONISTS; IMMUNOSUPPRESSIVE AGENTS; MUSCIMOL; OVARIECTOMY; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 0037146872     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)02272-5     Document Type: Conference Paper

References (19)

1. Beaumont K., Chilton W.S., Yamamura H.I., Enna S.J. Muscimol binding in rat brain: association with synaptic GABA receptors. Brain Research. 148(1):1978;153-162.
2. Dohgu S., Kataoka Y., Ikesue H., Naito M., Tsuruo T., Oishi R., Sawada Y. Involvement of glial cells in cyclosporine-increased permeability of brain endothelial cells. Cellular and Molecular Neurobiology. 20(6):2000;781-786.
3. Garcia-Segura L.M., Azcoitia I., DonCarlos L.L. Neuroprotection by estradiol. Progress in Neurobiology. 63(1):2001;29-60.
4. Gijtenbeek J.M.M., Van den Bert M.J., Vecht Ch. J. Cyclosporine neurotoxicity: a review. Journal of Neurology. 246(5):1999;339-346.
5. Green A.R. Changes in γ-amminobutyric acid biochemistry and seisure threshold. Annals of the New York Academy of Sciences. 462:1986;105-119.
6. Green P.S., Simpkins J.W. Neuroprotective effects of estrogens: potential mechanisms of action. International Journal of Developmental Neuroscience. 18(4/5):2000;347-358.
7. Greendale G.A., Lee N.P., Arriola E.R. The menopause. Lancet. 353:1999;571-580.
8. Kahan B.D. Cyclosporine. New England Journal of Medicine. 321(25):1989;1725-1738.
9. Kochi S., Takanaga H., Matsuo H., Naito M., Tsuruo T., Sawada Y. Effect of cyclosporine A or tacrolimus on the function of blood-brain barrier cells. European Journal of Pharmacology. 372(3):1999;287-295.
10. Pearce M.J., Hawton K. Psychological and sexual aspects of the menopause and HRT. Bailliere's Clinical Obstetrics and Gynaecology. 10(3):1996;385-399.
11. Pirsch J.D., Miller J., Deierhoi M.H., Vincenti F., Filo R.S. A comparision of tacrolimus (FK 506) and cyclosporine for immunosuppression after cadaveric renal transplantation. Transplantation. 63(7):1997;977-983.
12. A receptors in the dorsal hippocampus by estradiol and progesterone. Brain Research. 487(1):1989;178-183.
13. Shuto H., Kataoka Y., Fujisaki K., Nakao T., Sueyasu M., Miura I., Watanabe Y., Fujiwara M., Oishi R. Inhibition of GABA system involved in cyclosporine-induced convulsions. Life Sciences. 65(9):1999;879-887.
14. Snyder S.H., Sabatini D.M., Lai M.M., Steinet J.P., Hamilton G.S., Suzdak P.D. Neuronal actions of immunophilin ligands. Trends in Pharmacological Sciences. 19(1):1998;21-26.
15. Steiner J.P., Dawson T.M., Fotuhi M., Synder S.H. Immunophilin regulation of neurotransmitter release. Molecular medicine. 2(3):1996;325-333.
16. A comparision of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation. New England Journal of Medicine. 331(17):1994;1110-1115.
17. Tominaga K., Yamauchi A., Shuto H., Niizeki M., Makino K., Oishi R., Kataoka Y. Ovariectomy aggravates convulsions and hippocampal γ-aminobutyric acid inhibition induced by cyclosporin A in rats. European Journal of Pharmacology. 430(2/3):2001;243-249.
18. Veliskova J., Velisek L., Galanopooulou A.S., Sperber E.F. Neuroprotective effects of estrogens on hippocampal cells in adult female rats after status epilepticus. Epilepsia. 41(Suppl. 6):2000;S30-S35.
19. Yakel J.L. Calcineurin regulation of synaptic function: from ion shannels to transmitter release and gene transcription. Trends in Pharmacological Sciences. 18(4):1997;124-134.