Paradigm shifts in vaccine development: Lessons learned about antigenicity, pathogenicity and virulence of Brucellae

Veterinary Microbiology

Volumn 90, Issue 1-4, 2002, Pages 545-552

  Halling, Shirley M ^a  

^a NATIONAL ANIMAL DISEASE CENTER   (United States)

Author keywords

BCSP31; Brucella abortus; Cu Zn SOD; feuP Q; recA

Indexed keywords

BACTERIAL PROTEIN; BCSP31 VACCINE; BRUCELLA VACCINE; COPPER ZINC SUPEROXIDE DISMUTASE; PROTEIN FEUP; PROTEIN HTRA; RB51 VACCINE; RECA PROTEIN; UNCLASSIFIED DRUG;

ANTIGENICITY; BACTERIAL VIRULENCE; BRUCELLA ABORTUS; BRUCELLOSIS; CELL SURVIVAL; CELLULAR IMMUNITY; COLONY FORMING UNIT; DRUG EFFECT; DRUG EFFICACY; GENE LOCUS; GENE MUTATION; GENETIC ENGINEERING; HELA CELL; HOST; HUMAN; MACROPHAGE; MAMMAL CELL; MEDICAL RESEARCH; NONHUMAN; PATHOGENICITY; REVIEW; VACCINATION;

ANIMALIA; BOVINAE; BRUCELLA; BRUCELLA MELITENSIS BIOVAR ABORTUS; MAMMALIA;

EID: 0037146662     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1135(02)00234-1     Document Type: Article

References (37)

1. Angus R.D., Barton C.E. The production and evaluation of a buffered plate antigen for use in a presumptive test for brucellosis. Dev. Biol. Stand. 56:1984;349-356.
2. Beck B.L., Tabatabai L.B., Mayfield J.E. A protein isolated from B. abortus is a Cu-Zn superoxide dismutase. Biochemistry. 29:1990;372-376.
3. Bricker B.J., Halling S.M. Differentiation of B. abortus bv. 1, 2, and 4, B. melitensis, B. ovis, and B. suis bv. 1 by PCR. J. Clin. Microbiol. 32:1994;2660-2666.
4. Bricker B.J., Tabatabai L.B., Deyoe B.L., Mayfield J.E. Conservation of antigenicity in a 31-kDa Brucella protein. Vet. Microbiol. 18:1988;313-325.
5. Buchmeier N.A., Lipps C.J., So M.Y., Heffron F. Recombination-deficient mutants of Salmonella typhimurium are avirulent and sensitive to the oxidative burst of macrophages. Mol. Microbiol. 7:1991;933-936.
6. Cheville N.F., Olsen S.C., Jensen A.E., Stevens M.G., Palmer M.V., Florance A.M. Effects of age at vaccination on efficacy of B. abortus strain RB51 to protect cattle against brucellosis. Am. J. Vet. Res. 57:1996;1153-1156.
7. Cheville N.F., Stevens M.G., Jensen A.E., Tatum F.M., Halling S.M. Immune responses and protection against infection and abortion in cattle experimentally vaccinated with mutant strains of B. abortus. Am. J. Vet. Res. 54:1993;1591-1597.
8. Dorrell, N., Spencer, S., Foulonge, V., Guigue-Talet, P., O'Callaghan, D., Wren, B.W., 1999. Identification, cloning and initial characterisation of FeuP/Q in Brucella suis: a new sub-family of two-component regulatory systems.
9. Edmonds M., Booth N., Hagius S., Walker J., Enright F., Roop R.M., Elzer P. Attenuation and immunogenicity of a B. abortus htrA cycL double mutant in cattle. Vet. Microbiol. 76:2000;81-90.
10. Elzer P.H., Kovach M.E., Phillips R.W., Robertson G.T., Peterson K.M., Roop R.M. In vivo and in vitro stability of the broad-host-range cloning vector pBBR1MCS in six Brucella species. Plasmid. 33:1995;51-57.
11. Groisman E.A. The pleiotropic two-component regulatory system PhoP-PhoQ. J. Bacteriol. 183:2001;1835-1842.
12. Halling S.M., Zehr E.S. Polymorphism in Brucella spp. due to highly repeated DNA. J. Bacteriol. 172:1990;6637-6640.
13. Halling S.M., Detilleux P.G., Tatum F.M., Judge B.A., Mayfield J.E. Deletion of the BCSP31 gene of B. abortus by replacement. Infect. Immun. 59:1991;3863-3868.
14. Halling S.M., Tatum F.M., Bricker B.J. Sequence and characterization of an insertion sequence, IS711, from Brucella ovis. Gene. 133:1993;123-127.
15. Kovach M.E., Phillips R.W., Elzer P.H., Roop R.M., Peterson K.M. pBBR1MCS: a broad-host-range cloning vector. Biotechniques. 16:1994;800-802.
16. Latimer E., Simmers J., Sriranganathan N., Roop R.M., Schurig G.G., Boyle S.M. B. abortus deficient in copper/zinc superoxide dismutase is virulent in BALB/c mice. Microb. Pathog. 12:1992;105-113.
17. O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L., Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M. A homologue of the Agrobacterium tumefaciens VirB and B. pertussis Ptl type IV secretion systems is essential for intracellular survival of B. suis. Mol. Microbiol. 33:1999;1210-1220.
18. Oñate A.A., Vemulapalli R., Andrews E., Schurig G.G., Boyle S.M., Folch H. Vaccination with live E. coli expressing B. abortus Cu/Zn superoxide dismutase protects mice against virulent B. abortus. Infect. Immun. 67:1999;986-988.
19. Ouahrani S., Michaux S., Sri Widada J., Bourg G., Tournebize R., Ramuz M., Liautard J.P. Identification and sequence analysis of IS6501, an insertion sequence in Brucella spp.: relationship between genomic structure and the number of IS6501 copies. J. Gen. Microbiol. 139:1993;3265-3273.
20. Roop R.M., Fletcher T.W., Sriranganathan N.M., Boyle S.M., Schurig G.G. Identification of an immunoreactive B. abortus HtrA stress response protein homologue. Infect. Immun. 62:1994;1000-1007.
21. Sangari F.J., Aguero J. Molecular basis of Brucella pathogenicity: an update. Microbiologia. 12:1996;207-218.
22. Schurig G.G., Roop R.M., Bagchi T., Boyle S., Buhrman D., Sriranganathan N. Biological properties of RB51: a stable rough strain of B. abortus. Vet. Microbiol. 28:1991;171-188.
23. Sola-Landa A., Pizarro-Cerda J., Grillo M.J., Moreno E., Moriyon I., Blasco J.M., Gorvel J.P., Lopez-Goni I. A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in B. abortus and controls cell invasion and virulence. Mol. Microbiol. 29:1998;125-138.
24. Sriranganathan N., Boyle S.M., Schurig G., Misra H. Superoxide dismutases of virulent and avirulent strains of B. abortus. Vet. Microbiol. 26:1991;359-366.
25. Stabel T.J., Mayfield J.E., Tabatabai L.B., Wannemuehler M.J. Oral immunization of mice with attenuated Salmonella typhimurium containing a recombinant plasmid which codes for production of a 31-kDa protein of B. abortus. Infect. Immun. 58:1990;2048-2055.
26. Stevens M.G., Tabatabai L.B., Olsen S.C., Cheville N.F. Immune responses to superoxide dismutase and synthetic peptides of superoxide dismutase in cattle vaccinated with B. abortus strain 19 or RB51. Vet. Microbiol. 41:1994;383-389.
27. Tabatabai L.B., Hennager S.G. Cattle serologically positive for B. abortus have antibodies to B. abortus Cu-Zn superoxide dismutase. Clin. Diagn. Lab. Immunol. 1:1994;506-510.
28. Tabatabai L.B., Pugh G.W. Jr. Modulation of immune responses in Balb/c mice vaccinated with B. abortus Cu-Zn superoxide dismutase synthetic peptide vaccine. Vaccine. 12:1994;919-924.
29. Tabatabai L.B., Deyoe B.L., Patterson J.M. Immunogenicity of B. abortus salt-extractable proteins. Vet. Microbiol. 20:1989;49-58.
30. Tatum F.M., Cheville N.F., Morfitt D. Cloning, characterization and construction of htrA and htrA-like mutants of B. abortus and their survival in BALB/c mice. Microb. Pathog. 17:1994;23-36.
31. Tatum F.M., Morfitt D.C., Halling S.M. Construction of a B. abortus RecA mutant and its survival in mice. Microb. Pathog. 14:1993;177-185.
32. Tatum F.M., Detilleux P.G., Sacks J.M., Halling S.M. Construction of Cu-Zn superoxide dismutase deletion mutants of B. abortus: analysis of survival in vitro in epithelial and phagocytic cells and in vivo in mice. Infect. Immun. 60:1992;2863-2869.
33. Ugalde R.A. Intracellular lifestyle of Brucella spp. Common genes with other animal pathogens, plant pathogens, and endosymbionts. Microbes. Infect. 1:1999;1211-1219.
34. Vemulapalli R., Cravero S., Calvert C.L., Toth T.E., Sriranganathan N., Boyle S.M., Rossetti O.L., Schurig G.G. Characterization of specific immune responses of mice inoculated with recombinant vaccinia virus expressing an 18-kDa outer membrane protein of B. abortus. Clin. Diagn. Lab. Immunol. 7:2000;114-118.
35. Vemulapalli R., He Y., Cravero S., Sriranganathan N., Boyle S.M., Schurig G.G. Overexpression of protective antigen as a novel approach to enhance vaccine efficacy of B. abortus strain RB51. Infect. Immun. 68:2000;3286-3289.
36. Vizcaino N., Cloeckaert A., Zygmunt M.S., Dubray G. Cloning, nucleotide sequence, and expression of the Brucella melitensis omp31 gene coding for an immunogenic major outer membrane protein. Infect. Immun. 64:1996;3744-3751.
37. Vizcaino N., Cloeckaert A., Zygmunt M.S., Fernandez-Lago L. Molecular characterization of a Brucella species large DNA fragment deleted in B. abortus strains: evidence for a locus involved in the synthesis of a polysaccharide. Infect. Immun. 67:1999;2700-2712.