Development of (R)-4-hydroxymandelonitrile synthesis in an aqueous-organic biphasic stirred tank batch reactor

Biotechnology and Bioengineering

Volumn 79, Issue 2, 2002, Pages 154-164

  Willeman, W F ^a   Neuhofer, R ^b   Wirth, I ^b   Pochlauer P ^b   Straathof, A J J ^a   Heijnen, J J ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b DSM Fine Chemicals Austria Nfg GmbH & Co KG   (Netherlands)

Author keywords

(R) 4 hydroxymandelonitrile; 4 hydroxybenzaldehyde; Biphasic reaction; Cyanohydrins; Oxynitrilase; Process model; Prunus amygdalus hydroxy nitrile lyase; Stirred tank reactor

Indexed keywords

BIOCONVERSION; BIOSYNTHESIS; CATALYSIS; COMPUTER SIMULATION; ENZYMES; ETHERS; MASS TRANSFER; REACTION KINETICS; VOLUME FRACTION;

ORGANIC PHASE;

NITROGEN COMPOUNDS;

4 HYDROXYBENZALDEHYDE; 4 HYDROXYMANDELONITRILE; CYANOHYDRIN; HYDROXYLNITRILE LYASE; LYASE; NITRILE; UNCLASSIFIED DRUG; 4-HYDROXYBENZALDEHYDE; 4-HYDROXYMANDELONITRILE; BENZALDEHYDE DERIVATIVE; ETHER DERIVATIVE; HYDROGEN CYANIDE; HYDROXYMANDELONITRILE LYASE; METHYL TERT-BUTYL ETHER; TERT BUTYL METHYL ETHER;

APRICOT; ARTICLE; BATCH REACTOR; CATALYSIS; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; CONCENTRATION RESPONSE; ENANTIOMER; ENZYME KINETICS; EQUILIBRIUM CONSTANT; NONHUMAN; PARTITION COEFFICIENT; PROCESS MODEL; STIRRED REACTOR; SYNTHESIS; TEMPERATURE DEPENDENCE; BIOREACTOR; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; ENZYMOLOGY; NUT; PH; PRUNUS; QUALITY CONTROL; SENSITIVITY AND SPECIFICITY; TEMPERATURE;

ALDEHYDE-LYASES; BENZALDEHYDES; BIOREACTORS; CATALYSIS; COMPARATIVE STUDY; COMPUTER SIMULATION; HYDROGEN CYANIDE; HYDROGEN-ION CONCENTRATION; METHYL ETHERS; MODELS, CHEMICAL; MODELS, MOLECULAR; NITRILES; NUTS; PRUNUS; QUALITY CONTROL; SENSITIVITY AND SPECIFICITY; SUPPORT, NON-U.S. GOV'T; TEMPERATURE;

PRUNUS; PRUNUS DULCIS;

EID: 0037142771     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10317     Document Type: Article

References (21)

1. Biocatalysis in the enantioselective formation of chiral cyanohydrins, valuable building blocks in organic synthesis
2. Hydroxynitrile lyases in stereoselective catalysis
3. Synthese und Reaktionen optisch aktiver Cyanhydrine
4. Difficult substrates in the R-hydroxynitrile lyase catalyzed hydrocyanation reaction: Application of the mass transfer limitation principle in a two-phase system
5. Mass transport limitation as a tool to enhance the enantiomeric excess in the enzymatic synthesis of chiral cyanohydrins
6. Cyanohydrins in nature and the laboratory: Biology, preparations and synthetic applications
7. Enzyme catalysed formation of (S)-cyanohydrins derived from aldehydes and ketones in a biphasic solvent system
8. The synthesis of chiral cyanohydrins by oxynitrilases
9. Biocatalytic applications of hydroxy-nitrile lyases
10. (R)- and (S)-cyanohydrins using oxynitrilases in whole cells
11. Synthesis of optically active cyanohydrins using R-oxynitrilase in a liquid-liquid biphasic system
12. Syntheses of homochiral cyanohydrins in an industrial environment: Hydroxynitrile lyases offer new options
13. Development of a computer program for analysis of enzyme kinetics by process curve fitting
14. The potential of (R)- and (S)-oxynitrilases for the enzymatic synthesis of optically active cyanohydrins
15. Estimation of kinetic parameters by progress curve analysis for the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase
16. Development of a process model to describe the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase in an aqueous-organic biphasic reactor
17. Comparison of a batch, fed batch and continuous operated stirred tank reactor for the enzymatic conversion of (R)-mandelonitrile by using a process model
18. Reaction temperature optimization procedure for the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase using a process model approach