Equilibrium modeling of extractive enzymatic hydrolysis of penicillin G with concomitant 6-aminopenicillanic acid crystallization

Biotechnology and Bioengineering

Volumn 78, Issue 4, 2002, Pages 395-402

  Diender, M B ^a   Straathof, A J J ^a   Van Der Does, T ^b   Ras, C ^a   Heijnen, J J ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b DSM RESOLVE   (Netherlands)

Author keywords

Crystallization; Equilibrium prediction; Multiphase systems; Partitioning; Penicillin G

Indexed keywords

ANTIBIOTICS; CRYSTALLIZATION; ENZYME IMMOBILIZATION; EXTRACTION; FERMENTATION; HYDROLYSIS; ORGANIC SOLVENTS; PH EFFECTS; PURIFICATION; REDUCTION;

REACTANTS;

DRUG PRODUCTS;

6 AMINOPENICILLANIC ACID; PENICILLIN G;

ARTICLE; CHROMATOGRAPHY; CRYSTALLIZATION; DRUG ISOLATION; ENZYME MECHANISM; FERMENTATION; HYDROLYSIS; MOLECULAR MODEL; PARTITION CHROMATOGRAPHY; PARTITION COEFFICIENT; PROTEIN PROCESSING; REACTION ANALYSIS; STOICHIOMETRY;

ACETATES; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTER SIMULATION; CRYSTALLIZATION; ESCHERICHIA COLI; FERMENTATION; GLYCINE; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MODELS, CHEMICAL; PENICILLANIC ACID; PENICILLIN AMIDASE; PENICILLIN G; POTASSIUM; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; WATER;

EID: 0037141592     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10242     Document Type: Article

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