Expression of rat liver glutathione-S-transferase GSTA5 in cell lines provides increased resistance to alkylating agents and toxic aldehydes

Chemico-Biological Interactions

Volumn 140, Issue 2, 2002, Pages 121-135

  Kazi, Shubana ^a   Ellis, Elizabeth M ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Aldehydes; Alkylating agents; Glutathione S transferase (GST); Lipid peroxidation products

Indexed keywords

4 HYDROXYNONENAL; ACROLEIN; ALDEHYDE DERIVATIVE; ALKYLATING AGENT; CHLORAMBUCIL; GLUTATHIONE TRANSFERASE; GLYOXAL DERIVATIVE; HYDROGEN PEROXIDE; ISOENZYME; KANAMYCIN KINASE; MELPHALAN; MUCONALDEHYDE; XENOBIOTIC AGENT;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DETOXIFICATION; EUKARYOTIC CELL; EVALUATION; IC 50; LIPID PEROXIDATION; LIVER; MOLECULAR CLONING; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT;

ALDEHYDES; ALKYLATING AGENTS; ANIMALS; CELL LINE; CELL SURVIVAL; CHLORAMBUCIL; CRICETINAE; GLUTATHIONE TRANSFERASE; ISOENZYMES; LIPID PEROXIDATION; LIVER; MELPHALAN; PYRUVALDEHYDE; RATS;

CRICETINAE; CUCUMBER MOSAIC VIRUS; EUKARYOTA;

EID: 0037140654     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(02)00023-6     Document Type: Article

References (43)

1. Glutathione-S-transferases: Amino acid sequence comparison classification and phylogenetic relationship
2. Identification of three classes of cytosolic glutathione-S-transferase common to several mammalian species: Correlation between structural data and enzymatic properties
3. Theta, a new class of glutathione-S-transferases purified from rat and man
4. An enzyme from rat liver catalysing conjugations with glutathione
5. Molecular mechanisms of drug resistance
6. Overexpression of a novel anionic glutathione-S-transferase in multidrug resistant human breast cancer cells
7. Increased Glutathione-S-Transferase activity in a cell line with acquired resistance to nitrogen mustards
8. Characterization of melphalan-gluathione adducts whose formation is catalysed by glutathione-S-transferases
9. The spontaneous and glutathione-S-transferase mediated reaction of chlorambucil with glutathione
10. Cellular response to cancer chemopreventive agents: Contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress
11. Glutathione-S-transferases: A possible role in the detoxication of DNA and lipid hydroperoxides
12. Aldehydic lipid products of lipid per oxidation
13. Lipid per-oxidation products: Formation, chemical properties and biological activities
14. Cloning of cDNAs from foetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1
15. Expression of stably transfected murine glutathione S-transferase A3-3 protects against nucleic acid alkylation and cytotoxicity by aflatoxin bi in hamster V79 cells expressing rat cytochrome P450-2B1
16. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
17. Proetin blotting: Principles and applications
18. Firefly luciferase gene: Structure and expression in mammalian cells
19. A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein dye binding
20. Assays for differentiation of glutathione-S-transferases
21. Overexpression of aldehyde reductase protects PC12 cells from the cytotoxicity of methylglyoxal or 3-deoxyglucosone
22. Glutathione-S-Transferases in nitrogen mustard-resistant and sensitive cell lines
23. Dechlorination of L-phenylalanine mustard by sensitive and resistant tumour cells and its relationship to intracellular glutathione content
24. Glutathione and glutathione dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: Intrinsic differences and cell cycle effects
25. Biological activities of 4-hydroxyalkenals
26. The glyoxylase system in health and disease
27. Expression of recombinant glutathione-S-transferase pi, Ya or Ybi confers resistance to alkylating agents
28. Expression of rat glutathione-S-transferase cDNA in rat mammary carcinoma cells: Impact upon alkylator-induced toxicity
29. Promotor-glutathione-S-transferase cDNA hybrid genes. Expression and conferred resistance to an alkylating molecule in mammalian cells
30. Role of rnultidrug resistance protein 1 (MRP1) and glutatione S-transferase Al-1 in alkylating agent resistance
31. Natural occurring carbonyl compounds are mutagens in Salmonella tester strain TA104
32. Reaction of glutathione with conjugated carbonyls
33. Inactivation of glutathione reductase by 4-hydroxynonenal and other endogenous aldehydes
34. Rat GST8-8, an enzyme efficiently detoxifying 4-hydroxyalk-2-enals
35. Glutathione and the evolution of enzymes for detoxication of products of oxygen metabolism
36. Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium
37. Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004
38. The mechanism of action of glyoxylase
39. Glyoxylase activity in human tumour cell lines in vitro
40. Mechanism of the inhibition of growth of human leukaemia 60 cells by S-D-lactoylglutathione
41. Inhibition of proliferation of human promyelocytic leukaemia HL60 cells by S-D-lactoylglutathione in vitro