SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38 MAP kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 16, 2002, Pages 2109-2112

  Revesz, Laszlo ^a   Di Padova, Franco E ^a   Buhl, Thomas ^a   Feifel, Roland ^a   Gram, Hermann ^a   Hiestand, Peter ^a   Manning, Ute ^a   Wolf, Romain ^a   Zimmerlin, Alfred G ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT; COLLAGEN; HETEROCYCLIC COMPOUND; IMIDAZOLE DERIVATIVE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; OXAZOLE DERIVATIVE; PYRROLE DERIVATIVE; SYNAPTOPHYSIN; THIAZOLE DERIVATIVE; TRIAZOLE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PYRIDONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; HISTOLOGY; JOINT; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; HUMAN; METABOLISM; PATHOLOGY;

ANIMALS; ARTHRITIS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; LIPOPOLYSACCHARIDES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR STRUCTURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDONES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037136006     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00336-0     Document Type: Article

References (26)