Side-chain metabolism of propranolol: Involvement of monoamine oxidase and mitochondrial aldehyde dehydrogenase in the metabolism of N-desisopropylpropranolol to naphthoxylactic acid in rat liver

Life Sciences

Volumn 70, Issue 22, 2002, Pages 2687-2697

  Imamura, Yorishige ^a   Wu, Xiuzohng ^b   Noda, Atsuko ^b   Noda, Hiroshi ^c  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Aldehyde dehydrogenase; Enantioselective metabolism; Monoamine oxidase; Propranolol; Rat hepatocytes; Rat liver mitochondria

Indexed keywords

ALDEHYDE DEHYDROGENASE; AMINE OXIDASE (FLAVIN CONTAINING); CYANAMIDE; DEISOPROPYLPROPRANOLOL; DRUG METABOLITE; LACTIC ACID DERIVATIVE; NAPHTHOXYLACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROPRANOLOL; PROPRANOLOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DEAMINATION; DRUG CLEARANCE; DRUG METABOLISM; ENANTIOSELECTIVITY; ENZYME MECHANISM; LIVER CELL; LIVER CLEARANCE; LIVER CYTOSOL; LIVER METABOLISM; LIVER MICROSOME; LIVER MITOCHONDRION; MALE; NONHUMAN; RAT;

ALDEHYDE REDUCTASE; ALDEHYDES; ANIMALS; ANTIDOTES; CELL CULTURE TECHNIQUES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYANAMIDE; CYTOSOL; HEPATOCYTES; LACTATES; LIVER; MALE; MITOCHONDRIA, LIVER; MONOAMINE OXIDASE; OXIDATION-REDUCTION; PROPRANOLOL; PYRAZOLES; RATS; RATS, WISTAR; STEREOISOMERISM;

GYMNOMYZA SAMOENSIS;

EID: 0037134256     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)01540-0     Document Type: Article

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