[125I]-N-[(3-Azido-5-iodo)benzyl]dantrolene and [125I]-N-{[3-Iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl} dantrolene: Photoaffinity probes specific for the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 22, 2002, Pages 3263-3265

  Hosoya, Takamitsu ^a,b   Aoyama, Hiroshi ^b   Ikemoto, Takaaki ^c   Hiramatsu, Toshiyuki ^b   Kihara, Yasutaka ^c   Endo, Makoto ^c   Suzuki, Masaaki ^a,b  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; DANTROLENE; HYDANTOIN; IODINE 125; N [(3 AZIDO 5 IODO)BENZYL]DANTROLENE; N [[3 IODO 5 (3 TRIFLUOROMETHYL 3H DIAZIRIN 3 YL)]BENZYL]DANTROLENE; UNCLASSIFIED DRUG; CALCIUM; CENTRAL MUSCLE RELAXANT; DRUG DERIVATIVE; GIF 0082; N ((3 IODO 5 (3 TRIFLUOROMETHYL 3H DIAZIRIN 3 YL))BENZYL)DANTROLENE; N-((3-IODO-5-(3-TRIFLUOROMETHYL-3H-DIAZIRIN-3-YL))BENZYL)DANTROLENE; RADIOACTIVE IODINE;

ARTICLE; CALCIUM TRANSPORT; CHEMICAL STRUCTURE; REGULATORY MECHANISM; SARCOPLASMIC RETICULUM; SKELETAL MUSCLE; ANIMAL; DRUG EFFECT; METABOLISM; MOUSE; MUSCLE CONTRACTION; PHOTOAFFINITY LABELING; PHYSIOLOGY; SYNTHESIS; TRANSPORT AT THE CELLULAR LEVEL; ULTRASTRUCTURE;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM; DANTROLENE; IODINE RADIOISOTOPES; MICE; MUSCLE CONTRACTION; MUSCLE RELAXANTS, CENTRAL; MUSCLE, SKELETAL; PHOTOAFFINITY LABELS; SARCOPLASMIC RETICULUM;

EID: 0037131769     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00701-1     Document Type: Article

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28. Before handling the radioisotope, the reproducibility of the reaction was confirmed by examining iododestannylation under 'cold' conditions similar to the actual conditions used.
29. 125I]-6 required rather longer irradiation time (10 min) for complete decomposition even using the 100 W UV-lamp (365 nm).
30. Actually, we have succeeded in capturing novel molecules by using these specific photoaffinity probes. Their structures and functions will be reported separately in due course.