Listeriolysin O: A genuine cytolysin optimized for an intracellular parasite

Journal of Cell Biology

Volumn 156, Issue 6, 2002, Pages 943-946

  Dramsi, Shaynoor ^a   Cossart, Pascale ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

Listeria; pH; Phagosome; Toxin; Virulence

Indexed keywords

CHOLESTEROL; CYTOLYSIN; LISTERIOLYSIN;

AMINO ACID SUBSTITUTION; BACTERIAL VIRULENCE; CELL MEMBRANE; CELL PERMEABILIZATION; GRAM POSITIVE BACTERIUM; HOST CELL; LISTERIA MONOCYTOGENES; MOLECULAR BIOLOGY; NONHUMAN; PARASITE; PH; PHAGOSOME; PRIORITY JOURNAL; REVIEW;

ANIMALS; BACTERIAL TOXINS; HEAT-SHOCK PROTEINS; HEMOLYSIN PROTEINS; HOST-PARASITE RELATIONS; HUMANS; HYDROGEN-ION CONCENTRATION; LISTERIA MONOCYTOGENES; MUTATION; PARASITES; PROTEIN STRUCTURE, TERTIARY; VACUOLES;

BACTERIA (MICROORGANISMS); LISTERIA; LISTERIA MONOCYTOGENES; POSIBACTERIA;

EID: 0037128931     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200202121     Document Type: Review

References (17)

1. pH-dependent perforation of macrophage phagosomes by listeriolysin O from Listeria monocytogenes
2. Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells
3. The effects of inhibitors of vacuolar acidification on the release of Listeria monocytogenes from phagosomes of Caco-2 cells
4. Interactions of Listeria monocytogenes with mammalian cells during entry and actin-based movement: Bacterial factors, cellular ligands and signaling
5. Listeriolysin O is essential for virulence of Listeria monocytogenes: Direct evidence obtained by gene complementation
6. A PEST-like sequence in listeriolysin O essential for Listeria monocytogenes pathogenicity
7. Purification, characterization and toxicity of the sutfhydryl-activated hemolysin listeriolysin O from Listeria monocytogenes
8. The L. monocytogenes hemolysin has an acidic pH optimum to compartimentalize activity and prevent damage to infected host cells
9. Difference in cholesterol-binding and cytolytic activities between listeriolysin O and seeligeriolysin O: A possible role of alanine residue in tryptophan-rich undecapeptide
10. Characterization of Listeria monocyrogenes pathogenesis in a strain expressing perfringolysin O in place of listeriolysin O
11. Conversion of an extracellular cytolysin into a phagosome-specific lysin which supports the growth of an intracellular pathogen
12. Delivery of macromolecules into cytosol using liposomes containing hemolysin from Listeria monocytogenes
13. Identification of a PEST-like motif in listeriolysin O required for phagosomal escape and for virulence in Listeria monocytogenes
14. Attenuated mutants of the intracellular bacterium Listeria monocytogenes obtained by single amino acid substitutions in listeriolysin O
15. Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form
16. The mechanism of membrane insertion for a cholesterol-dependent cytolysin: A novel paradigm for pore-forming toxins
17. Listeria pathogenesis and molecular virulence determinants