The long-term effects of nefiracetam on learning in older rabbits

Behavioural Brain Research

Volumn 136, Issue 1, 2002, Pages 299-308

  Woodruff Pak, Diana S ^a,b   Green, John T ^b   Pak, Jonathan T ^b   Shiotani, Tadashi ^c   Watabe, Shigeo ^c   Tanaka, Makoto ^c  

^a EINSTEIN MEDICAL CENTER   (United States)

^b TEMPLE UNIVERSITY   (United States)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

Aging; Alzheimer's disease; Cognition enhancing drug; Eyeblink classical conditioning; Hippocampus; Nicotinic acetylcholine receptors; Relearning; Retention

Indexed keywords

NEFIRACETAM;

ADAPTATION; ARTICLE; CONDITIONING; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; EYELID REFLEX; FEMALE; LATENT PERIOD; LEARNING; NONHUMAN; PRIORITY JOURNAL; RABBIT; TASK PERFORMANCE; TRAINING;

AGING; ANIMALS; BLINKING; CONDITIONING, CLASSICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INJECTIONS, INTRAVENOUS; LEARNING; MEMORY; MOVEMENT; NOOTROPIC AGENTS; PYRROLIDINONES; RABBITS;

EID: 0037126174     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(02)00186-9     Document Type: Article

References (39)

1. Berger T.W., Rinaldi P.C., Weisz D.J., Thompson R.F. Single-unit analysis of different hippocampal cell types during classical conditioning of rabbit nictitating membrane response. J. Neurophysiol. 50:1983;1197-1219.
2. Berger T.W., Thompson R.F. Identification of pyramidal cells as critical in hippocampal neuronal plasticity during learning. Proc. Natl. Acad. Sci. USA. 75:1978;1572-1576.
3. Coffin J.M., Woodruff-Pak D.S. Delay classical conditioning in young and older rabbits: acquisition and retention at 12 and 18 months. Behav. Neurosci. 107:1993;63-71.
4. Coyle J.T., Price D.L., DeLong M.R. Alzheimer's disease: a disorder of cortical cholinergic innervation. Science. 219:1983;1184-1190.
5. Daum I., Schugens M.M. On the cerebellum and classical conditioning. Curr. Dir. Psychol. Sci. 5:1996;58-61.
6. Funk K.F., Schmidt J. Changes of dopamine metabolism by hypoxia and effect of nootropic drugs. Biomed. Biochem. Acta. 11:1984;1301-1304.
7. Hall T.C., Miller K.H., Corsellis J.A.N. Variations in the human Purkinje cell population according to age and sex. Neuropathol. Appl. Neurobiol. 1:1975;267-292.
8. Ito M. The cerebellum and neural control. 1984;Raven Press, New York.
9. Lemieux S.K., Woodruff-Pak D.S. Functional MRI studies of eyeblink classical conditioning. Woodruff-Pak D.S., Steinmetz J.E., Eyeblink classical conditioning volume 1: applications in humans. 2000;71-93 Kluwer Academic Publishers, Boston.
10. Logan C.G., Grafton S.T. Functional anatomy of human eyeblink classical conditioning determined with regional cerebral glucose metabolism and positron-emission topography. Proc. Natl. Acad. Sci. USA. 92:1995;7500-7504.
11. Marchi M., Besana E., Raiteri M. Oxiracetam increases the release of endogenous glutamate from depolarized rat hippocampal slices. Eur. J. Pharmacol. 185:1990;247-249.
12. McKinney M., Coyle J.T., Hedreen J.C. Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system. J. Comp. Neurol. 217:1983;103-111.
13. Nabeshima T. Ameliorating effects of nefiracetam (DM-9384) on brain dysfunction. Drugs Today. 30:1994;357-379.
14. Nabeshima T., Noda Y., Tohyama K., Itoh J., Kameyama T. Effects of DM-9384 in a model of amnesia based on animals with GABAergic neuronal dysfunctions. Eur. J. Pharmacol. 178:1990;143-149.
15. Nakamura J., Higashi H., Nishi S., Nakazawa Y. DM-9384, a pyrrolidone derivative, protects the membrane dysfunction induced by deprivation of oxygen and glucose in guinea-pig hippocampal neurons in vitro. Biol. Psychiatry (Suppl Abst). 11:1991;29-36.
16. Olpe H.-R., Lynch G.S. The action of piracetam on the electrical activity of the hippocampal slice preparation: a field potential analysis. Eur. J. Pharmacol. 80:1982;415-419.
17. Powell D.A., Buchanan S.L., Hernandez L.L. Intraseptal scopolamine has differential effects on Pavlovian eye blink and heart rate conditioning. Behav. Neurosci. 99:1985;75-87.
18. Salvatierra A.T., Berry S.D. Scopolamine disruption of septo-hippocampal activity and classical conditioning. Behav. Neurosci. 103:1989;715-721.
19. Satoh M., Ishihara K., Iwama T., Takagi H. Aniracetam augments, and midazolam inhibits, the long-term potentiation in guinea pig hippocampal slices. Neurosci. Lett. 68:1986;216-220.
20. Scheibel M.E., Lindsay R.D., Tomiyasu U., Scheibel A.B. Progressive dendritic changes in the human limbic system. Exp. Neurol. 53:1976;420-430.
21. 3H]acetylcholine in rat brain. Life Sci. 38:1986;2111-2120.
22. Solomon P.R., Barth C.L., Wood M.S., Velasquez E., Groccia-Ellison M.E., Yang B.Y. Age-related deficits in retention of the classically conditioned eyeblink response in rabbits. Behav. Neurosci. 109:1995;18-23.
23. Solomon P.R., Gottfried K.E. The septo-hippocampal cholinergic system and classical conditioning of the rabbit's nictitating membrane response. J. Comp. Physiol. Psychol. 95:1981;322-330.
24. Solomon P.R., Solomon S.D., Vander Schaaf E., Perry H.E. Altered activity in the hippocampus is more detrimental to classical conditioning than removing the structure. Science. 220:1983;329-331.
25. Spencer D.G. Jr, Horvath E., Raber J. Direct autoradiographic determination of M1 and M2 muscarinic acetylcholine receptor distribution in the rat brain: relation to cholinergic nuclei and projections. Brain Res. 380:1986;59-68.
26. Spignoli G., Pepeu G. Interactions between oxiracetam, quaniracetam, and scopolamine on behavior and brain acetylcholine. Pharmacol. Biochem. Behav. 27:1987;491-495.
27. Steinmetz J.E. The brain substrates of classical eyeblink conditioning in rabbits. Bloedel J.R., Ebner T.J., Wise S.P., The acquisition of motor behavior in vertebrates. 1996;89-114 MIT Press, Cambridge, MA.
28. Thompson R.F., Krupa D.J. Organization of memory traces in the mammalian brain. Ann. Rev. Neurosci. 17:1994;519-549.
29. Watabe S., Yamaguchi H., Ashida S. DM-9384, a new cognition-enhancing agent, increases the turnover of components of the GABAergic system in the rat cerebral cortex. Eur. J. Pharmacol. 238:1993;303-309.
30. West M.J., Coleman P.D., Flood D.G., Troncoso J.C. Differences in the pattern of hippocampal neuronal loss in normal aging and Alzheimer's disease. Lancet. 344:1994;769-772.
31. Woodruff-Pak D.S. Evaluation of cognition-enhancing drugs: utility of the model system of eyeblink classical conditioning. CNS Drug Rev. 1:1995;107-128.
32. Woodruff-Pak D.S. Evidence for the role of cerebellum in classical conditioning in humans. Schmahmann J.D., The cerebellum and cognition. 1997;341-366 Academic Press, San Diego.
33. Woodruff-Pak D.S., Cronholm J.F., Sheffield J.B. Purkinje cell number related to rate of eyeblink classical conditioning. Neuroreport. 1:1990;45-48.
34. Woodruff-Pak D.S., Lavond D.G., Logan C.G., Thompson R.F. Classical conditioning in 3-, 30-, and 45-month-old rabbits: behavioral learning and hippocampal unit activity. Neurobiol. Aging. 8:1987;101-108.
35. Woodruff-Pak D.S., Li Y.-T. Nefiracetam (DM-9384): effect on classical conditioning in older rabbits. Psychopharmacology. 114:1994;200-208.
36. Woodruff-Pak D.S., Li Y.-T., Hinchcliffe R.M., Port R.L. Hippocampus in delay eyeblink classical conditioning: essential for nefiracetam amelioration of learning in older rabbits. Brain Res. 747:1997;207-218.
37. Woodruff-Pak D.S., Li Y.-T., Kazmi A., Kem W.R. Nicotinic cholinergic system involvement in eyeblink classical conditioning in rabbits. Behav. Neurosci. 108:1994;486-493.
38. Woodruff-Pak D.S., Trojanowski J.Q. The older rabbit as an animal model: implications for Alzheimer's disease. Neurobiol. Aging. 17:1996;283-290.
39. Yoshii M., Watabe S. Enhancement of neuronal calcium channel currents by the nootropic agent, nefiracetam (DM-9384), in NG108-14 cells. Brain Res. 642:1994;123-131.