Sorbitol dehydrogenase inhibitors (SDIs): A new potent, enantiomeric SDI, 4-[2-1R-hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1-sulfonic acid dimethylamide

Journal of Medicinal Chemistry

Volumn 44, Issue 17, 2001, Pages 2695-2700

  Mylari, B L ^a   Oates, P J ^a   Beebe, D A ^a   Brackett, N S ^a   Coutcher, J B ^a   Dina, M S ^a,b   Zembrowski, W J ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 (1 HYDROXYETHYL)PYRIMIDIN 4 YL]PIPERAZINE 1 SULFONIC ACID DIMETHYLAMIDE; ENZYME INHIBITOR; GLUCOSE; IDITOL DEHYDROGENASE; POLYOL; SORBITOL DEHYDROGENASE INHIBITOR; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG POTENCY; ENANTIOMER; ENZYME INHIBITION; GLUCOSE TRANSPORT; IN VIVO STUDY; NONHUMAN; RAT; SCIATIC NERVE; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; ENZYME INHIBITORS; FRUCTOSE; HUMANS; L-IDITOL 2-DEHYDROGENASE; PYRIMIDINES; RATS; SCIATIC NERVE; STEREOISOMERISM; SULFONAMIDES; TISSUE DISTRIBUTION;

EID: 0035899194     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0102001     Document Type: Article

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