Differential changes in messenger RNA expressions and binding sites of neuropeptide Y Y1, Y2 and Y5 receptors in the hippocampus of an epileptic mutant rat: Noda epileptic rat

Neuroscience

Volumn 115, Issue 4, 2002, Pages 1035-1045

  Jinde, S ^a   Masui, A ^b   Morinobu, S ^c   Noda, A ^d   Kato, N ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^c HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^d Research Institute for Animal Science in Biochemistry and Toxicology   (Japan)

Author keywords

Animal model; Epilepsy; Immunohistochemistry; In situ hybridization; Receptor autoradiography; Spontaneous seizure

Indexed keywords

KAINIC ACID; MESSENGER RNA; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR; PEPTIDE DERIVATIVE; PEPTIDE YY[31 LEUCINE 34 PROLINE] I 125; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING ASSAY; BINDING SITE; BRAIN REGION; CONTROLLED STUDY; DENTATE GYRUS; DRUG EFFECT; DRUG RECEPTOR BINDING; EPILEPSY; EPILEPTOGENESIS; GRAND MAL SEIZURE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; KINDLING; MALE; MOSSY FIBER; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN ISOLATION; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; TONIC CLONIC SEIZURE;

ANIMALS; DENTATE GYRUS; DISEASE MODELS, ANIMAL; EPILEPSY; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IODINE RADIOISOTOPES; MALE; MOSSY FIBERS, HIPPOCAMPAL; NEURONS; NEUROPEPTIDE Y; PEPTIDE FRAGMENTS; PYRAMIDAL CELLS; RATS; RATS, MUTANT STRAINS; RECEPTORS, NEUROPEPTIDE Y; RNA, MESSENGER;

EID: 0037121660     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00545-6     Document Type: Article

References (42)

1. Baraban S.C., Hollopeter G., Erickson J.C., Schwartzkroin P.A., Palmiter R.D. Knock-out mice reveal a critical antiepileptic role for neuropeptide Y. J. Neurosci. 17:1997;8927-8936.
2. 4 subtype receptor for pancreatic polypeptide, neuropeptide Y and peptide YY. J. Biol. Chem. 270:1995;26762-26765.
3. Blomqvist A.G., Herzog H. Y-receptor subtypes - How many more? Trends Neurosci. 20:1997;294-298.
4. 5 receptor binding sites in two experimental models of epilepsy. Neuroscience. 98:2000;697-703.
5. Chafetz R.S., Nahm W.K., Noebels J.L. Aberrant expressions of neuropeptide Y in hippocampal mossy fibers in the absence of local cell injury following the onset of spike-wave synchronization. Mol. Brain Res. 31:1995;111-121.
6. Colmers W.F., Lukowiak K., Pittman Q.J. Neuropeptide Y action in the rat hippocampal slice: site and mechanism of presynaptic inhibition. J. Neurosci. 8:1988;3827-3837.
7. deQuidt M.E., Emson P.C. Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system-II. Immunohistochemical analysis. Neuroscience. 18:1986;545-618.
8. 5 receptor subtype in the rat brain. J. Neurosci. 18:1998;5565-5574.
9. 2 receptor radioligands. Synapse. 22:1996;139-158.
10. Dumont Y., Fournier A., StPierre S., Quirion R. Comparative characterization and autoradiographic distribution of neuropeptide Y receptor subtypes in rat brain. J. Neurosci. 13:1993;73-86.
11. Erickson J.C., Clegg K.E., Palmiter R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 381:1996;415-421.
12. Eva C., Keinanen K., Monyer H., Seeburg P., Sprengel R. Morecular cloning of a novel G-protein-coupled receptor that may belong to the neuropeptide receptor family. FEBS Lett. 271:1990;81-84.
13. Flood J.F., Morley J.E. Dissociation of the effects of neuropeptide Y on feeding and memory: evidence for pre- and postsynaptic mediation. Peptides. 10:1989;963-966.
14. 1 receptors. Eur. J. Pharmacol. 10:1998;757-759.
15. Gerald C., Walker M.W., Criscione L., Gustafson E.L., Bartz-Hartmann C., Smith K.E., Vaysse P., Durkin M.M., Laz T.M., Linemeyer D.L., Schaffhauser A.O., Whitebread S., Hofbauer K.G., Taber R.L., Branchek T.A., Wainshank R.L. A receptor subtype involved in neuropeptide Y-induced food intake. Nature. 382:1996;168-171.
16. 2 receptors in the rat hippocampus associated with kindling epileptogenesis. J. Neurochem. 70:1998;1615-1622.
17. 2 receptors in rat hippocampal slices in vitro. Br. J. Pharmacol. 113:1994;737-740.
18. Heilig M., Widerlöv E. Neuropeptide Y: an overview of central distribution, functional aspects, and possible involvement in neuropsychiatric illnesses. Acta Psychiatr. Scand. 82:1990;95-114.
19. 5 receptors reduce synaptic excitation in proximal subiculum, but not epileptiform activity in rat hippocampus slices. J. Neurophysiol. 83:2000;723-734.
20. Jinde S., Masui A., Morinobu S., Takahashi Y., Tsunashima K., Noda A., Yamada N., Kato N. Elevated neuropeptide Y and corticotropin-releasing factor in the brain of a novel epileptic mutant rat: Noda epileptic rat. Brain Res. 833:1999;286-290.
21. Klapstein G.J., Colmers W.F. Neuropeptide Y suppresses epileptiform activity in rat hippocampus in vitro. J. Neurophysiol. 78:1997;1651-1661.
22. 1 receptors in kainic acid induced epilepsy in rats. Neurosci. Lett. 230:1997;129-132.
23. Kopp J., Nanobashvili A., Kokaia Z., Lindvall O., Hokfelt T. Differential regulation of mRNAs for neuropeptide y and its receptor subtypes in widespread areas of the rat limbic system durling kindling epileptogenesis. Mol. Brain Res. 72:1999;17-29.
24. 5 neuropeptide Y receptor in limbic seizures. Proc. Natl. Acad. Sci. USA. 96:1999;13518-13523.
25. Nakamura M., Aoki Y., Hirano D. Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor. Biochim. Biophys. Acta. 1284:1996;134-137.
26. Noda A., Hashizume R., Maihara T., Tomizawa Y., Ito Y., Inoue M., Kobayashi K., Asano Y., Sasa M., Serikawa T. NER rat strain: a new type of genetic model in epilepsy research. Epilepsia. 39:1998;99-107.
27. Röder C., Schwarzer C., Vezzani A., Gobbi M., Mennini T., Sperk G. Autoradiographic analysis of neuropeptide Y receptor binding sites in the rat hippocampus after kainic acid-induced limbic seizures. Neuroscience. 70:1996;47-55.
28. Sadamatsu M., Kanai H., Masui A., Serikawa T., Yamada Y., Sasa M., Kato N. Altered brain contents of neuropeptides in spontaneously epileptic rats (SER) and tremor rats with absence seizures. Life Sci. 57:1995;523-531.
29. 2 receptors in rat dentate gyrus. Neurotoxicol. Teratol. 20:1998;607-610.
30. Sasa M., Hanaya R., Iida K., Akimitsu T., Kurusu K., Noda A., Serikawa T. A novel epilepsy animal model (NER). Jpn. J. Psychopharmacol. 17:1997;35-38.
31. 2 receptors in an amimal model of temporal lobe epilepsy. Mol. Pharmacol. 53:1998;6-13.
32. Sperk G., Marksteiner J., Gruber B., Bellmann R., Mahata M., Ortler M. Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat. Neuroscience. 50:1992;831-846.
33. Takahashi Y., Sadamatsu M., Kanai H., Masui A., Amano S., Ihara N., Kato N. Changes of immunoreactive neuropeptide Y, somatostatin and corticotropin-releasing factor (CRF) in the brain of a novel epileptic mutant rat, Ihara's genetically epileptic rat (IGER). Brain Res. 776:1997;255-260.
34. Takahashi Y., Tsunashima K., Miyuki S., Schwarzer C., Amano S., Ihara N., Sasa M., Kato N., Sperk G. Altered hippocampal expression of neuropeptide Y, somatostatin, and glutamate decarboxylase in Ihara's epileptic rats and spontaneously epileptic rats. Neurosci. Lett. 287:2000;105-108.
35. Tatemoto K., Carlquist M., Mutt V. Neuropeptide Y - A novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature. 296:1982;659-660.
36. Tønder N., Kragh J., Finsen B.R., Bolwig T.G., Zimmer J. Kindling induces transient changes in neuronal expression of somatostatin, neuropeptide Y and Calbindin in adult rat hippocampus and fascia dentate. Epilepsia. 35:1994;1299-1308.
37. Tsunashima K., Sadamatsu M., Takahashi Y., Kato N., Sperk G. Trimethyltin intoxication induces marked changes in neuropeptides expression in the rat hippocampus. Synapse. 29:1998;333-342.
38. Tsunashima K., Wokersdorfer M., Schwarzer C., Sperk G., Fischer Colbrie R. Limbic seizures induce neuropeptide and chromogranin mRNA expression in rat adrenal medulla. Mol. Brain Res. 51:1997;42-48.
39. Vezzani A., Schwarzer C., Lothman E.W., Williamson J., Sperk G. Functional changes in somatostatin and neuropeptide Y containing neurons in the rat hippocampus in chronic models of limbic seizures. Epilepsy Res. 26:1996;267-279.
40. Vezzani A., Sperk G., Colmers W.F. Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci. 22:1999;25-30.
41. Weinberg D.H., Sirinathsinghji D.J., Tan C.P., Shiao L.L., Morin N., Rigby N.R., Heavens N.H., Rapoport D.R., Bayne M.L., Cascieri M.A., Strader C.D., Linemayer D.L., MacNeil D.J. Cloning and expression of a novel neuropeptide Y receptor. J. Biol. Chem. 271:1996;16435-16438.
42. 5-like receptors. Nat. Med. 3:1997;761-764.