Altered hippocampal expression of neuropeptide Y, somatostatin, and glutamate decarboxylase in Ihara's epileptic rats and spontaneously epileptic rats

Neuroscience Letters

Volumn 287, Issue 2, 2000, Pages 105-108

  Takahashi, Yoshinari ^a   Tsunashima, Koichi ^a   Sadamatsu, Miyuki ^a   Schwarzer, Christoph ^b   Amano, Shigeru ^a   Ihara, Nobuo ^c   Sasa, Masashi ^d   Kato, Nobumasa ^a   Sperk, Günther ^b  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c Institute of ICR Research   (Japan)

^d HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Epilepsy; Glutamate decarboxylase; Ihara's epileptic rat; Neuropeptide Y; Somatostatin; Spontaneously epileptic rat

Indexed keywords

GLUTAMATE DECARBOXYLASE; NEUROPEPTIDE Y; SOMATOSTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPILEPTOGENESIS; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; TISSUE DISTRIBUTION;

ANIMALS; EPILEPSY; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTAMATE DECARBOXYLASE; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; NEUROPEPTIDE Y; RATS; RATS, MUTANT STRAINS; RATS, WISTAR; RNA, MESSENGER; SOMATOSTATIN;

EID: 0034705651     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01133-2     Document Type: Article

References (17)

1. Amano S., Ihara N., Uemura S., Yokoyama M., Ikeda M., Serikawa T., Sasahara M., Kataoka H., Hayase Y., Hazama F. Development of a novel rat mutant with spontaneous limbic-like seizures. Am. J. Pathol. 149:1996;329-336.
2. Erickson J.C., Clegg K.E., Palmiter R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 381:1996;415-421.
3. Erlander M.G., Tillakaratne N.J., Feldblum S., Patel N., Tobin A.J. Two genes encode distinct glutamate decarboxylases. Neuron. 7:1991;91-100.
4. A receptors and GABA transporter (GAT) in the hippocampus of Ihara Epileptic Rat: quantitative RT-PCR and in situ hybridization studies. Eplepsia. 2000;. in press.
5. Jinde S., Masui A., Morinobu S., Takahashi Y., Tsunashima K., Noda A., Yamada N., Kato N. Elevated neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) in the brain of a novel epileptic mutant rat: Noda epileptic rat (NER). Brain. Res. 833:1999;286-290.
6. Larhammar D., Ericsson A., Persson H. Structure and expression of the rat neuropeptide Y gene. Proc. Natl. Acad. Sci. USA. 84:1987;2068-2072.
7. Marksteiner J., Sperk G. Concomitant increase of somatostatin, neuropeptide Y and glutamate decarboxylase in the frontal cortex of rats with decreased seizure threshold. Neuroscience. 26:1988;379-385.
8. Sadamatsu M., Kanai H., Masui A., Serikawa T., Yamada J., Sasa M., Kato N. Altered brain contents of neuropeptides in spontaneously epileptic rats (SER) and tremor rats with absence seizures. Life. Sci. 57:1995;523-531.
9. Schwarzer C., Sperk G. Hippocampal granule cells express glutamic acid decarboxylase-67 after limbic seizures in the rat. Neuroscience. 69:1995;705-709.
10. Serikawa T., Ohno Y., Sasa M., Yamada J., Takaori S. A new model of petit mal epilepsy: spontaneous spike and wave discharges in tremor rats. Lab. Anim. 21:1987;68-71.
11. Sloviter R.S. Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy. Science. 235:1987;73-76.
12. Sperk G. Kainic acid seizures in the rat. Prog. Neurobiol. 42:1994;1-32.
13. Sperk G., Widmann R. Somatostatin precursor in the rat striatum: changes after local injection of kainic acid. J. Neurochem. 45:1985;1441-1447.
14. Takahashi Y., Sadamatsu M., Kanai H., Masui A., Amano S., Ihara N., Kato N. Changes of immunoreactive neuropeptide Y, somatostatin and corticotropin-releasing factor (CRF) in the brain of a novel epileptic mutant rat, Ihara's genetically epileptic rat (IGER). Brain Res. 776:1997;255-260.
15. Tavianini M.A., Hayes T.E., Magazin M.D., Minth C.D., Dixon J.E. Isolation, characterization, and DNA sequence of the rat somatostatin gene. J. Biol. Chem. 259:1984;11798-11803.
16. Tsunashima K., Sadamatsu M., Takahashi Y., Kato N., Sperk G. Trimethyltin intoxication induces marked changes in neuropeptide expression in the rat hippocampus. Synapse. 29:1998;333-342.
17. Vezzani A., Civenni G., Rizzi M., Monno A., Messali S., Samanin R. Enhanced neuropeptide Y release in the hippocampus is associated with chronic seizure susceptibility in kainic acid treated rats. Brain. Res. 660:1994;138-143.