L-type Ca2+ channel modulation by dihydropyridines potentiates κ-opioid receptor agonist induced acute analgesia and inhibits development of tolerance in rats

Neuropharmacology

Volumn 42, Issue 4, 2002, Pages 467-475

  Gullapalli, S ^a   Ramarao, P ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Bmax; Calcium channel blockers; DHP binding; Kd; L type Ca2+ channels; Tail flick analgesia; Tolerance; Opioid receptor agonists

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; BENZENEACETAMIDE DERIVATIVE; CALCIUM CHANNEL L TYPE; CANNABINOID; DIHYDROPYRIDINE DERIVATIVE; KAPPA OPIATE RECEPTOR; N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZO[B]THIOPHENE 4 ACETAMIDE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; PYRROLE DERIVATIVE; PYRROLIDINE DERIVATIVE; THIOPHENE DERIVATIVE; 1,4 DIHYDROPYRIDINE; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; ISRADIPINE; KAPPA OPIATE RECEPTOR AGONIST; LERCANIDIPINE; NIMODIPINE; TRITIUM;

ANALGESIA; ANIMAL; ARTICLE; DOSE RESPONSE; DRUG POTENTIATION; DRUG TOLERANCE; MALE; METABOLISM; METHODOLOGY; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; STATISTICS; ANIMAL TISSUE; AREA UNDER THE CURVE; BINDING SITE; BRAIN MEMBRANE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SUPERSENSITIVITY; TAIL FLICK TEST;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESIA; ANIMALS; BENZENEACETAMIDES; CALCIUM CHANNELS, L-TYPE; CANNABINOIDS; DIHYDROPYRIDINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG TOLERANCE; MALE; PYRROLES; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, KAPPA; THIOPHENES;

EID: 0036010553     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00200-3     Document Type: Article

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