Screening and mass spectral confirmation of β-lactam antibiotic residues in milk using LC-MS/MS

Journal of Agricultural and Food Chemistry

Volumn 50, Issue 2, 2002, Pages 406-411

  Holstege, D M ^a   Puschner, B ^a   Whitehead, G ^a   Galey, F D ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WYOMING   (United States)

Author keywords

lactam antibiotic; HPLC; LC MS; Mass spectrometry

Indexed keywords

ACETONITRILE; AMOXICILLIN; AMPICILLIN; BETA LACTAM ANTIBIOTIC; CEFAPIRIN; CEFTIOFUR; CLOXACILLIN; DRUG RESIDUE; PENICILLIN G; PENICILLIN V; WATER; ANTIINFECTIVE AGENT; BETA LACTAM;

ANALYTIC METHOD; ANIMAL; ARTICLE; CALIBRATION; CHEMISTRY; CONTROLLED STUDY; DAIRY PRODUCT; FOOD AND DRUG ADMINISTRATION; FOOD CONTAMINATION; FOOD SAFETY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; MILK; NONHUMAN; PROTON TRANSPORT; QUANTITATIVE ASSAY; REPRODUCIBILITY; SCREENING TEST; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

ANIMALIA; BOVINAE;

ANIMALS; ANTI-BACTERIAL AGENTS; BETA-LACTAMS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG RESIDUES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MASS SPECTROMETRY; MILK; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 0037116441     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf010994s     Document Type: Article

References (10)

1. The need for epidemiologic validation of diagnostic assays used to detect antibiotic residues in milk
2. Chromatographic methods of analysis of antibiotics in milk
3. Multiresidue determination of β-lactam antibiotics in milk and tissues with the aid of high-performance liquid chromatographic fractionation for clean up
4. Simultaneous determination of six penicillins in cows raw milk by a multiresidue high-performance liquid chromatographic method
5. Simultaneous determination of β-lactam antibiotics in milk by ion-pair liquid chromatography
6. Development of analytical methods for some penicillins in bovine milk by ion-pair chromatography and confirmation by thermospray mass spectometry
7. Determination of penicillin G, ampicillin, amoxicillin, cloxacillin and cephapirin by high-performance liquid chromatography-electrospray mass spectrometry
8. Simultaneous multiresidue analysis of β-lactam antibiotics in bovine milk by liquid chromatography with ultraviolet detection and confirmation by electrospray mass spectrometry
9. Confirmatory assay for the simultaneous detection of five penicillins in muscle, kidney and milk using liquid chromatography-electrospray mass spectrometry
10. Electrospray ionization and tandem ion trap mass spectrometry for the confirmation of seven β-lactam antibiotics in bovine milk