B cell development arrest upon insertion of a neo gene between JH and Eμ: Promoter competition results in transcriptional silencing of germline JH and complete V(D)J rearrangements

Journal of Immunology

Volumn 169, Issue 12, 2002, Pages 6875-6882

  Delpy, Laurent ^a   Decourt, Catherine ^a   Le Bert, Marc ^a   Cogné, Michel ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN J CHAIN; CRE RECOMBINASE; IMMUNOGLOBULIN MU CHAIN; INTEGRASE; NEOMYCIN; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE REARRANGEMENT; GENE SILENCING; GENE TARGETING; GENETIC TRANSCRIPTION; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SPLEEN CELL; TRANSCRIPTION REGULATION; ALLELE; ANIMAL; ANTIBODY SPECIFICITY; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL DEATH; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DNA METHYLATION; ENHANCER REGION; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC MARKER; GENETICS; HETEROZYGOTE DETECTION; HOMOZYGOTE; HYBRIDOMA; IMMUNOLOGY; INTRON; MALE; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; MOUSE MUTANT; MUTATION; STEM CELL; TRANSGENIC MOUSE;

ALLELES; ANIMALS; ANTIBODY DIVERSITY; B-LYMPHOCYTE SUBSETS; BASE SEQUENCE; CELL DEATH; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; DNA METHYLATION; ENHANCER ELEMENTS (GENETICS); FEMALE; GENE DELETION; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENE SILENCING; GENETIC MARKERS; GERM-LINE MUTATION; HETEROZYGOTE DETECTION; HOMOZYGOTE; HYBRIDOMAS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN J-CHAINS; IMMUNOGLOBULIN MU-CHAINS; INTEGRASES; INTRONS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; NEOMYCIN; PROMOTER REGIONS (GENETICS); STEM CELLS; TRANSCRIPTION, GENETIC; VIRAL PROTEINS;

EID: 0037114169     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.12.6875     Document Type: Article

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