Interaction between tris(4-chlorophenyl)methanol and the human androgen receptor in vitro

Toxicology Letters

Volumn 136, Issue 1, 2002, Pages 19-24

  Schrader, Timothy J ^a   Cooke, Gerard M ^a,b  

^a TOXICOLOGY RESEARCH DIVISION   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Androgen; Human; Receptor; TCPM

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; ANDROGEN RECEPTOR; ANDROSTANOLONE; LUCIFERASE; METHANOL DERIVATIVE; TRIS(4 CHLOROPHENYL)METHANOL; UNCLASSIFIED DRUG; VINCLOZOLIN;

ADIPOSE TISSUE; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; KINETICS; PRIORITY JOURNAL; PROTEIN INTERACTION;

ADIPOSE TISSUE; CELL LINE; CELL SURVIVAL; COLORING AGENTS; DICHLORODIPHENYL DICHLOROETHYLENE; ENVIRONMENTAL POLLUTANTS; HUMANS; KINETICS; MALE; NEUTRAL RED; PROSTATE; RECEPTORS, ANDROGEN; TRITYL COMPOUNDS;

EID: 0037111129     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00288-6     Document Type: Article

References (14)

1. Borenfreund E., Puerner J.A. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol. Lett. 24:1985;119-124.
2. Borras M., Hardy L., Lempreur F., El Khissiin A.H., Legros N., Gol-Winkler R., Leclercq G. Estradiol-induced down-regulation of estrogen receptor: effect of various modulators of protein synthesis and expression. J. Steroid Biochem. Mol. Biol. 48:1994;325-336.
3. Eisenthal R., Cornish-Bowden A. The direct linear plot: a new graphical procedure for estimating enzyme kinetic parameters. Biochem. J. 193:1974;715-720.
4. Falandysz J., Strandberg B., Strandberg L., Rappe C. Tris(4-chlorophenyl)methane and tris(4-chlorophenyl)methanol in sediment and food webs from the Baltic south coast. Environ. Sci. Technol. 33:1999;517-521.
5. Foster W.G., Desaulniers D., Leingartner K., Wade M.G., Poon R., Chu I. Reproductive effects of tris(4-chlorophenyl)methanol in the rat. Chemosphere. 39:1999;709-724.
6. Jarman W.M., Simon M., Norstrom R.J., Burns S.S., Bacon C.A., Simonett B.R.T., Rosebrough R.W. Global distribution of tris(4-chlorophenyl)methanol in high trophic level birds and mammals. Environ. Sci. Technol. 26:1992;1770-1774.
7. Kajiwara N., Kannan K., Muraoka M., Watanabe M., Takahashi S., Gulland F., Olsen H., Blankenship A.L., Jones P.D., Tanabe S., Giesy J.P. Organochlorine pesticides, polychlorinated biphenyls and butyltin compounds in blubber and livers of stranded California sea lions, elephant seals and harbour seals from coastal California, USA. Arch. Environ. Contam. Toxicol. 41:2001;90-99.
8. Kelce W.R., Monosson E., Gamcsik M.P., Laws S.C., Gray L.E. Jr. Environmental hormone disrupters: evidence that vinclozilin developmental toxicity is mediated by antiandrogenic metabolites. Toxicol. Appl. Pharmacol. 126:1994;276-285.
9. Kelce W.R., Stone C.R., Laws S.C., Gray L.E. Jr., Kemppainen J.A., Wilson E.M. Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature (London). 375:1995;581-585.
10. Minh T.B., Watanabe M., Tanabe S., Yamada T., Hata J.-I., Watanabe S. Occurrence of tris(4-chlorophenyl)methane, tris(4-chlorophenyl)methanol and some other persistent organochlorines in Japanese human adipose tissue. Environ. Health Perspect. 108:2000;599-603.
11. Minh T.B., Watanabe M., Tanabe S., Yamada T., Hata J.-I., Watanabe S. Specific accumulation and elimination kinetics of tris(4-chlorophenyl)methane, tris(4-chlorophenyl)methanol and other persistent organochlorines in humans from Japan. Environ. Health Perspect. 109:2001;927-935.
12. Poon R., Lecavalier P., Bergman A., Yagminas A., Chu I., Valli V.E. Effects of tris(4-chlorophenyl)methanol on the rat following short-term oral exposure. Chemosphere. 34:1997;1-12.
13. Schrader T.J., Cooke G.M. Examination of selected food additives and organochlorine food contaminants for androgenic activity in vitro. Toxicol. Sci. 53:2000;278-288.
14. Wilkinson G.N. Statistical estimations in enzyme kinetics. Biochem. J. 80:1961;324-332.