Synthesis and atomic force microscopy observations of the single-peptide nanotubes and their micro-order assemblies

Physical Review B - Condensed Matter and Materials Physics

Volumn 66, Issue 16, 2002, Pages 1654171-1654178

  Nakanishi, Tsutomu ^a   Okamoto, Hajime ^a   Nagai, Yukiko ^a   Takeda, Kyozaburo ^a   Obataya, Ikuo ^a   Mihara, Hisakazu ^b   Azehara, Hiroaki ^c   Suzuki, Yasumasa ^c   Mizutani, Wataru ^c   Furukawa, Kazuaki ^d   Torimitsu, Keiichi ^d  

^a WASEDA UNIVERSITY   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^d Kashino Diverse Brain Research Laboratory of NTT Communication Science Laboratories   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLO(3 GLUTAMINYL DEXTRO 3 ALANYL); CYCLO(4 GLUTAMINYL DEXTRO 4 ALANYL); HEXAPEPTIDE; PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; ATOMIC FORCE MICROSCOPY; BIOENGINEERING; ENERGY TRANSFER; IMAGING; NANOTECHNOLOGY; PEPTIDE SYNTHESIS; PROTEIN ASSEMBLY; SOLID; STRUCTURE ANALYSIS;

EID: 0037110083     PISSN: 01631829     EISSN: None     Source Type: Journal    
DOI: 10.1103/PhysRevB.66.165417     Document Type: Article

References (21)

1. M. R. Ghadiri, J. R. Granja, R. A. Milligan, D. E. McRee, and N. Khazanovich, Nature (London) 366, 324 (1993).
2. J. D. Hartgerink, J. R. Granja, R. A. Milligan, and M. R. Ghadiri, J. Am. Chem. Soc. 118, 43 (1996).
3. D. T. Bong, T. D. Clark, J. R. Granja, and M. R. Ghadiri, Angew. Chem. Int. Ed. 40, 988 (2001).
4. S. Fernandez-Lopez, Hui-Sun Kim, E. C. Choi, M. Delgado, J. R. Granja, A. Khasanov, K. Kraehenbuehl, G. Long, D. A. Weinberger, K. M. Wilcoxen, and M. R. Ghadiri, Nature (London) 412, 452 (2001).
5. K. Fukasaku, K. Takeda, and K. Shiraishi, J. Phys. Soc. Jpn. 66, 3387 (1997); 67, 375 (1998).
6. K. Fukasaku, K. Takeda, and K. Shiraishi, J. Phys. Soc. Jpn. 66, 3387 (1997); 67, 375 (1998).
7. J. P. Lewis, N. H. Pawley, and O. F. Sankey, J. Phys. Chem. B 101, 10 576 (1997).
8. P. Carloni, W. Andreoni, and M. Parrinello, Phys. Rev. Lett. 79, 761 (1997).
9. R. A. Jishi, N. C. Braier, C. T. White, and J. W. Mintmire, Phys. Rev. B 58, R16 009 (1998).
10. H. Okamoto, K. Takeda, and K. Shiraishi, Phys. Rev. B 64, 115425 (2001).
11. H. Okamoto, T. Nakanishi, Y. Nagai, M. Kasahara, and K. Takeda, Technical Report No. 2001-14, Advanced Research Institute for Sci. and Eng., Waseda Univ. (2001).
12. H. Okamoto, T. Nakanishi, Y. Nagai, K. Takeda, I. Obataya, H. Mihara, H. Azehara and W. Mizutani; Technical Report No. 2001-19, Advanced Research Institute for Sci. and Eng., Waseda Univ. (2001).
13. 5]) (Ref. 11). The resulting AFM images indicated the bent tubular forms of the penta-peptide nanotubes.
14. 4-], and compared their morphology.
15. M. J. Frisch, et al.; Gaussian 98, Gaussian, Inc., Pittsburgh, PA, (1998).
16. Y. Nagai; Thesis of Waseda University, 2001.
17. W. C. Chan and P. D. White; Fmoc Solid Phase Peptide Synthesis: A Practical Approach (Oxford University Press, New York, 2000), pp. 41-76.
18. 4=tetrakis (triphenylphosphine) palladium, PPD = piperidine, HBTU = 2-(1H- benzotriazole-1-yl)-1,1,3,3,-tetramethyluronium hexafluorophosphate, HOBt = 1-hydroxybenzotriazole hydrate, DIEA = N,N-diisopropylethylamine, BOP = benzotriazol-1-yloxy tris (dimethylamino) phosphonium hexafluorophosphate, TFA = trifluoroacetic acid, TIS = triisopropylsilane, DMSO = dimethyl sulphoxide, and NMP = N-methylpyrrolidone.
19. The synthesized peptides can also be dissolved in TFA. The solvent, however, does damage the substrate. Therefore, we tried to use only two organic solvents, DMSO and NMP, for the AFM observations.
20. Our AFM observations for neat DMSO on the Au substrate under the same conditions also show the projections with heights of 1.5-3.0 nm. However, the observed heights of the projections in 8PCR/DMSO/Au are larger than those.
21. We confirmed that neat NMP on the Au substrate does not form any projections. Therefore, we assume the observed projections in 6PCR/NMP/Au to be clumps of the peptides.