K(86Rb) transport heterogeneity in the low-density fraction of sickle cell anemia red blood cells

American Journal of Physiology - Cell Physiology

Volumn 271, Issue 4 40-4, 1996, Pages

  Etzion, Zipora ^b   Lew, Virgilio L ^b   Bookchin, Robert M ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NONE

Author keywords

bumetanide; erythrocytes; ion transport; ouabain; potassium; rubidium 86

Indexed keywords

BUMETANIDE; CHLORIDE ION; OUABAIN; POTASSIUM ION; RUBIDIUM 86; CARRIER PROTEIN; POTASSIUM; RUBIDIUM; SODIUM POTASSIUM CHLORIDE COTRANSPORTER;

ARTICLE; CELL PH; CONTROLLED STUDY; ERYTHROCYTE; HUMAN; HUMAN CELL; ION TRANSPORT; POTASSIUM CURRENT; PRIORITY JOURNAL; RETICULOCYTE; SICKLE CELL ANEMIA; BLOOD; CELL SEPARATION; DRUG EFFECT; ERYTHROCYTE DISORDER; METABOLISM; PH; TRANSPORT AT THE CELLULAR LEVEL;

STROPHANTHUS GRATUS;

ANEMIA, SICKLE CELL; BIOLOGICAL TRANSPORT; BUMETANIDE; CARRIER PROTEINS; CELL SEPARATION; ERYTHROCYTES, ABNORMAL; HUMANS; HYDROGEN-ION CONCENTRATION; OUABAIN; POTASSIUM; RUBIDIUM; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS;

EID: 0030267509     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1996.271.4.c1111     Document Type: Article

References (23)

1. Apovo, M., Y. Beuzard, F. Galacteros, D. Bachir, and F. Giraud. The involvement of the Ca-dependent K channel and of the KCl co-transport in sickle cell dehydration during cyclic deoxygenation. Biochim. Biophys. Acta 1225: 255-258, 1994.
2. Ballas, S. K., N. Mohandas, J. Cremins, G. M. Colella, and R. Langley. Contribution of reticulocytes and mature erythrocytes to cellular dehydration in various sickle cell syndromes (Abstract). Blood 80: 9a, 1992.
3. Bertles, J. F., and P. F. A. Milner. Irreversibly sickled erythrocytes: a consequence of the heterogeneous distribution of hemoglobin types in sickle cell anemia. J. Clin. Invest. 47: 1731-1741, 1968.
4. +, non-reticulocyte subpopulation of sickle cell anemia (SS) and normal (AA) red cells (RBCs) (Abstract). Blood 86: 473a, 1995.
5. Bookchin, R. M., Z. Etzion, M. P. Sorette, N. Mohandas, and V. L. Lew. Heterogeneity of ion transport in sickle cell anemia reticulocytes revealed by patterns of acid-induced dehydration (Abstract). Blood 82: 350a, 1993.
6. Bookchin, R. M., O. E. Ortiz, and V. L. Lew. Evidence for a direct reticulocyte origin of dense red cells in sickle cell anemia. J. Clin. Invest. 87: 113-124, 1991.
7. Brugnara, C., H. F. Bunn, and D. C. Tosteson. Regulation of erythrocyte cation and water content in sickle cell anemia. Science Wash. DC 232: 388-390, 1986.
8. Brugnara, C., and D. C. Tosteson. Cell volume, K transport, and cell density in human erythrocytes. Am. J. Physiol. 252 (Cell Physiol. 21): C269-C276, 1987.
9. -) co-transport system. Clin. Sci. 71: 465-476, 1986.
10. Corash, L. M., S. Piomelli, H. C. Chen, C. Seaman, and E. Gross. Separation of erythrocytes according to age on a simplified density gradient. J. Lab. Clin. Med. 84: 147-151, 1974.
11. Ellory, J. C., and G. W. Stewart. The human erythrocyte Cl-dependent Na-K cotransport system as a possible model for studying the action of loop diuretics. Br. J. Pharmacol. 75: 183-188, 1982.
12. Fabry, M. E., J. R. Romero, I. D. Buchanan, S. M. Suzuka, G. Stamatoyannopoulos, R. L. Nagel, and M. Canessa. Rapid increase in red blood cell density driven by K:Cl cotransport in a subset of sickle cell anemia reticulocytes and discocytes. Blood 78: 217-225, 1991.
13. Hall, A. C., and J. C. Ellory. Evidence for the presence of volume-sensitive KCl transport in "young" human red cells. Biochim. Biophys. Acta 858: 317-320, 1986.
14. Izumo, H., S. Lear, M. Williams, R. Rosa, and F. H. Epstein. Sodium-potassium pump, ion fluxes, and cellular dehydration in sickle cell anemia. J. Clin. Invest. 79: 1621-1628, 1987.
15. Joiner, C. H. Cation transport and volume regulation in sickle red blood cells. Am. J. Physiol. 264 (Cell Physiol. 33): C251-C270, 1993.
16. Lauf, P. K., J. Bauer, N. C. Adragna, H. Fujise, A. M. M. Zade-Oppen, K. H. Ryu, and E. Delpire. Erythrocyte K-Cl cotransport: properties and regulation. Am. J. Physiol. 263 (Cell Physiol 32): C917-C932, 1992.
17. Lew, V. L., and R. M. Bookchin. Volume, pH and ion content regulation in human red cells: analysis of transient behavior with an intregated model. J. Membr. Biol. 92: 57-74, 1986.
18. Lew, V. L., C. J. Freeman, O. E. Ortiz, and R. M. Bookchin. A mathematical model of the volume, pH and ion content in reticulocytes: application to the pathophysiology of sickle cell dehydration. J. Clin. Invest. 87: 100-112, 1991.
19. Lew, V. L., and J. Garcia-Sancho. Measurement and control of intracellular calcium in intact red cells. In: Methods in Enzymology. Biomembranes. Cellular and Subcellular Transport: Eukariotic (Nonepithelial) Cells, edited by S. Fleischer and B. Fleischer. San Diego, CA: Academic, 1989, vol. 173, pt. T, p. 100-112.
20. Lew, V. L., J. E. Raftos, M. Sorette, R. M. Bookchin, and N. Mohandas. Generation of normal human red cell volume, hemoglobin content and membrane area distributions, by "birth" or regulation? Blood 86: 334-341, 1995.
21. 86Rb) flux components. Blood 67: 710-715, 1986.
22. Panet, R., and H. Atlan. Characterization of a potassium carrier in rabbit reticulocyte cell membrane. J. Membr. Biol. 52: 273-280, 1980.
23. Sorette, M. P., K. Shiffer, and M. R. Clark. Improved isolation of normal human reticulocytes via exploitation of chloride-dependent potassium transport. Blood 80: 249-254, 1992.