Abnormal brain energy metabolism shown by in vivo phosphorus magnetic resonance spectroscopy in patients with chronic liver disease

Brain Research Bulletin

Volumn 59, Issue 1, 2002, Pages 75-82

  Barbiroli, B ^a   Gaiani, S ^b   Lodi, R ^a   Iotti, S ^a   Tonon, C ^a   Clementi, V ^a   Donati, G ^b   Bolondi, L ^b  

^a Dipartimento di Medicina Clinica e Biotecnologia Applicata D Campanacci   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Brain energy metabolism; Hepatic encephalopathy; Liver cirrhosis; Phosphocreatine; Phosphorus MR spectroscopy

Indexed keywords

CREATINE PHOSPHATE; PHOSPHATE; PHOSPHORUS;

ADULT; AEROBIC METABOLISM; AGED; AMMONIA BLOOD LEVEL; ARTICLE; BIOENERGY; BRAIN METABOLISM; CHRONIC LIVER DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; FEMALE; HEPATIC ENCEPHALOPATHY; HUMAN; IN VIVO STUDY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MALE; METABOLIC DISORDER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCIPITAL LOBE; PHOSPHORYLATION; PRIORITY JOURNAL;

ADENOSINE DIPHOSPHATE; ADULT; AGED; BRAIN; CELL RESPIRATION; CHRONIC DISEASE; ENERGY METABOLISM; FEMALE; HUMANS; LIVER DISEASES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MITOCHONDRIA; PHOSPHORUS RADIOISOTOPES;

EID: 0037107937     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(02)00839-0     Document Type: Article

References (58)

1. 31P NMR spectra acquired using the DRESS technique Magn. Reson. Med. 7:1989;88-94.
2. Balthar E.J. CT evaluation of esophageal varices. Am. J. Roentgenol. 148:1981;131-135.
3. Barbara, L.; Sama, C.; Malavolti, M. The importance of recognising subclinical hepatic encephalopathy. In: Rodes, J.; Arroyo, V., eds. Therapy in liver diseases. Barcelona: Ediciones Doyma VII; 1992:331-335.
4. 31P MR spectroscopy in patients with mitochondrial cytopathies J. Cereb. Blood Flow Metab. 13:1993;469-474.
5. Barbiroli B., Iotti S., Cortelli P., Martinelli P., Lodi R., Carelli V., Montagna P. Low brain intracellular free magnesium in mitochondrial cytopathies. J. Cereb. Blood Flow Metab. 19:1999;528-532.
6. 31P magnetic resonance spectroscopy reveals osmotic and metabolic disturbances in human hepatic encephalopathy J. Neurochem. 71:1998;1564-1576.
7. Bluml S., Moreno-Torres A., Ross B.D. [1-13C]glucose MRS in chronic hepatic encephalopathy in man. Magn. Reson. Med. 45:2001;981-993.
8. Bolondi L., Gandolfi L., Arienti V., Caletti G.C., Corcioni E., Gasbarrini G., Labo G. Ultrasonography in the diagnosis of portal hypertension: Diminished response of portal vessels to respiration. Radiology. 142:1982;167-172.
9. 1H -NMR spectroscopy and biochemical investigation Hepatology. 12:1990;281-290.
10. 13C NMR J. Magn. Reson. 59:1984;338-342.
11. Bottomley P.A., Hardy C.J. Rapid, reliable in vivo assay of human phosphate metabolites by nuclear magnetic resonance. Clin. Chem. 35:1989;392-395.
12. Butterworth R., Giguere J.F., Michaud J., Lavoie J., Pomier-Layrargues G. Ammonia: Key factor in the pathogenesis of hepatic encephalopathy. Neurochem. Pathol. 6:1987;1-12.
13. Chance B., Williams G. Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. J. Biol. Chem. 217:1955;383-393.
14. Chance B., Leigh J.S. Jr., Clark B.J., Maris J., Kent J., Nioka S., Smith D. Control of oxidative phosphorylation and oxygen delivery in human skeletal muscle: A steady-state analysis of the work/energy cost transfer function. Proc. Natl. Acad. Sci. U.S.A. 82:1985;8384-8388.
15. Chance B., Leigh J.S. Jr., Kent J., McCully K., Nioka S., Clark B.J., Maris J.M., Graham T. Multiple controls of oxidative metabolism in living tissues as studied by phosphorus magnetic resonance. Proc. Natl. Acad. Sci. U.S.A. 83:1986;9458-9462.
16. Chapman A.G., Westberger E., Siesjo B.K. The metabolism of purine and pyrimidine nucleotides in rat cortex during insulin-induced hypoglycemia and recovery. J. Neurochem. 36:1981;179-189.
17. Clark, B. J.; Smith, D.; Chance, B. Metabolic consequences of oxygen transport studied with phosphorus magnetic resonance spectroscopy. In: Bryan-Brown, C. W.; Ayres, S. M., eds. Oxygen transport and utilization. Fullerton, CA: Society for Critical Care Medicine; 1987:144-170.
18. Conn H.O. Trialmaking and number connection tests in the assessment of mental state in portal systemic encephalopathy. Am. J. Dig. Dis. 22:1977;541-550.
19. Conn, H. O.; Lieberthal, M. M. The hepatic coma syndromes and lactulose. Baltimore: William and Wilkins; 1979.
20. Conn, H. O. Assessment of the severity of hepatic encephalopathy. In: Rodes, J.; Arroyo, V., eds. Therapy in liver diseases. Barcelona: Ediciones Doyma VII; 1992:277-291.
21. Cooper A.J.L., Plum F. Biochemistry and physiology of brain ammonia. Physiol. Rev. 67:1987;440-519.
22. 31P magnetization transfer studies of creatine kinase kinetics in living rabbit brain Magn. Reson. Med. 5:1987;1-12.
23. 31P -NMR spectroscopy in the newborn. In: Guthrie, R. D., ed. Neonatal intensive care. New York: Churchill Livingstone; 1988:153-179.
24. EEC Concerted Research Project. Quality assessment in in vivo NMR spectroscopy. Results of a concerted Research Project of the European Economic Community (6 papers). Magn. Reson. Imaging 13:115-176; 1995.
25. Eleff S.M., Barker P.B., Blackband S.J., Chatham J.C., Lutz N.W., Johns R.D., Bryan R.N. Phosphorus magnetic resonance spectroscopy of patients with mitochondrial cytopathies demonstrates decreased levels of brain phosphocreatine. Ann. Neurol. 27:1990;626-630.
26. 31P nuclear magnetic resonance J. Neurochem. 52:1989;741-749.
27. Gaiani S., Bolondi L., Bassi S., Zironi G., Siringo S., Barbara L. Prevalence of spontaneous hepatofugal portal flow in liver cirrhosis. Gastroenterology. 100:1991;160-167.
28. Gitlin N. Subclinical portal-systemic encephalopathy. Am. J. Gastroenterol. 83:1988;8-11.
29. Grippon P., Le Poncin-Laffite M., Boschat M., Wang S., Faure G., Dutertre D., Opolon P. Evidence for the role of ammonia in the intracerebral transfer and metabolism of tryptophan. Hepatology. 6:1986;682-686.
30. Häussinger D., Laubenberger J., vom Dahl S., Ernst T., Bayer S., Langer M., Gerok W., Hennig J. Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Gastroenterology. 107:1994;1475-1480.
31. Hill, M. C.; Dach, J. L.; Shawker, T. H. Ultrasonography in portal hypertension. In: Benhamou, J. P.; Lebrc, D., eds. Clinic in gastroenterology. London: WB Saunders; 1985;83-104.
32. Hindfelt B., Plum F., Duffy T.E. Effect of acute ammonia intoxication on cerebral metabolism in rats with portcaval shunts. J. Clin. Invest. 59:1977;386-396.
33. Hindfelt, B. Ammonia intoxication and brain energy metabolism. In: Kleinbergere, G.; Deutsch, E., eds. New aspects of clinical nutrition. Basel: Karger; 1983:474-484.
34. Japanese Research Society for Portal Hypertension. The general rules for recording endoscopic findings on oesophageal varices. Jpn. J. Surg. 10:84-93; 1980.
35. Kanamori K., Ross B.D., Chung J.C., Kuo E.L. Severity of hyperammoniemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo. J. Neurochem. 67:1996;1584-1594.
36. Keevil S.F., Barbiroli B., Collins D., Heriksen O., Longo R., Moore C., Segebarth C., Smith M.A. Results of a multi-centre trial of test objects for localized in vivo NMR spectroscopy. Eurospin Q. 27:1991;63-69.
37. 1H NMR spectroscopy in patients with chronic hepatic encephaloptahy. Analysis of changes in cerebral glutamine NMR Biomed. 4:1991;109-116.
38. Lai J.C.K., Cooper A.J.L. Brain α-ketoglutarate dehydrogenase complex: Kinetic properties, regional distribution and effects of inhibitors. J. Neurochem. 47:1986;1376-1386.
39. Lavoie J., Giguére J.F., Layrrargues G.P., Butterworth R.F. Aminoacid changes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. J. Neurochem. 49:1987;692-697.
40. Lockwood A.H., Ginsberg M.D., Rhoades H.M., Gutierrez M.T. Cerebral glucose metabolism after portocaval shunting in the rat. Pattern of metabolism and implications for the pathogenesis of hepatic encephalopahy. J. Clin. Invest. 78:1986;121-123.
41. Lockwood A.H., Yap E.W.H., Rhoades H.M., Wong W.H. Altered cerebral blood flow and glucose metabolism with liver disease and minimal hepatic encephalopathy. J. Cereb. Blood Flow Metab. 11:1991;331-336.
42. Lodi R., Iotti S., Cortelli P., Pierangeli G., Cevoli S., Clementi V., Soriani S., Montagna P., Barbiroli B. Deficient energy metabolism is associated with low free magnesium in the brains of patients with migraine and cluster headache. Brain Res. Bull. 54:2001;437-441.
43. Matthews P.M., Arnold D.L. Phosphorus magnetic resonance spectroscopy of brain in mitochondrial cytopathies. Ann. Neurol. 28:1990;839-840.
44. McCain A.H., Bernardino M.E., Sones P.J., Berkman W.A., Gasarella W.J. Varices from portal hyprtension: Correlation of CT and angiography. Radiology. 154:1985;63-69.
45. 31P -NMR J. Appl. Physiol. 62:1987;2094-2102.
46. O'Carroll R.E., Hayes P.C., Ebmeier K.P., Dougall N., Murray C., Best J.J., Bouchier I.A., Goodwin G.M. Regional cerebral blood flow and cognitive function in patients with chronic liver disease. Lancet. 337:1991;1250-1253.
47. Parson-Smith B.G., Summerskill K.H.J., Dawson A.M., Sherlock S. The electroencephalograph in liver disease. Lancet. 2:1957;867-871.
48. 31P nuclear magnetic resonance spectroscopy Neurology. 35:1985;781-788.
49. Petroff O.A.C., Ogini T., Alger J.R. High resolution proton magnetic resonance spectroscopy of rabbit brain: Regional metabolite levels and postmortem changes. J. Neurochem. 51:1988;163-171.
50. Pugh R.N.H., Murray-Lyon I.M., Dawson J.L., Pietroni M.C., Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br. J. Surg. 60:1983;646-649.
51. 31P spectroscopic imaging shows energy deficit of thalamus in chronic hepatic encephalopathy. In: Book of Abstracts, Annual Meeting of the Society of Magnetic Resonance in Medicine, Amsterdam; 1989:465.
52. Ross B.D., Jacobsen S., Villamil F., Korula J., Kreis R., Ernst T., Shonk T., Moats R.A. Subclinical hepatic encephalopathy: Proton MR spectroscopic abnormalities. Radiology. 193:1994;457-463.
53. Taylor-Robinson S.D., Sargentoni J., Mallalieu R.J., Bell J.D., Bryant D.J., Coutts G.A., Morgan M.Y. Cerebral phosphorus-31 magnetic resonance spectroscopy in patients with chronic liver hepatic encephalopathy. Hepatology. 20:1994;1173-1178.
54. Taylor-Robinson S.D., Sargentoni J., Marcus C.D., Morgan M.Y., Bryant D.J. Regional variations in cerebral proton spectroscopy in patients with chronic hepatic encephalopathy. Metab. Brain Dis. 9:1994;347-359.
55. Taylor-Robinson S.D., Sargentoni J., Oatridge A., Bryant D.J., Hajnal J.V., Marcus C.D., Seery J.P., Hodgson H.J., deSouza N.M. MR imaging and spectroscopy of the basal ganglia in chronic liver disease: Correlation of T1-weighted contrast measurements with abnormalities in proton and phosphorus-31 MR spectra. Metab. Brain Dis. 11:1996;249-268.
56. Taylor-Robinson S.D., Buckley C., Changani K.K., Hodgson H.J.F., Bell J.D. Cerebral phosphorus-31 and proton magnetic resonance spectroscopy in patients with subclinical hepatic encephalopathy. Liver. 19:1999;389-398.
57. 13C -magnetic resonance spectroscopy Dev. Neurosci. 20:1998;427-433.
58. Veech R.L., Lawson J.W.R., Cornell N.W., Krebs H.A. Cytosolic phosphorylation potential. J. Biol. Chem. 254:1979;6538-6547.