The impact of protein biochips and microarrays on the drug development process

Drug Discovery Today

Volumn 7, Issue 18, 2002, Pages

  Huels, Christoph ^a   Muellner, Stefan ^a   Meyer, Helmut E ^c   Cahill, Dolores J ^b  

^a Fundamenta CAPITAL   (Germany)

^b MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^c PROTAGEN AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; G PROTEIN COUPLED RECEPTOR; PROTEIN; RNA; SILANE DERIVATIVE;

AMINO ACID SEQUENCE; AUTOMATION; BIOINFORMATICS; BIOLOGY; BIOTECHNOLOGY; DATA BASE; DEVICE; DNA DETERMINATION; DNA MICROARRAY; GENE CONTROL; GENE REPLICATION; GENE SEQUENCE; GENE TARGETING; GENE TECHNOLOGY; GENETIC CODE; GENETIC ENGINEERING; GENOME ANALYSIS; GENOMICS; PROTEIN FUNCTION; PROTEIN IMMOBILIZATION; PROTEIN POLYMORPHISM; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEOMICS; QUALITATIVE ANALYSIS; REPRODUCIBILITY; REVIEW; VALIDATION PROCESS;

DRUG EVALUATION, PRECLINICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN ARRAY ANALYSIS; PROTEOMICS;

EID: 0037107046     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(02)02389-9     Document Type: Review

References (38)

1. Calkins K. Holding all the chips. BioCentury The Bernstein Report on Biobusiness. 9:2001;A1-A3.
2. Frost & Sullivan (2001) The World Biochips Market, Report #7761-55.
3. The Boston Consulting Group (2001) A revolution in R&D, The Impact of Genomics, pp. 1-15 (http://www.bcg.de/start.asp)
4. Zhu H., et al. Global analysis of protein activities using proteome chips. Science. 293:2001;2101-2105.
5. Gaertner H.F., et al. Site-specific attachment of functionalized poly (ethylene glycol) to the amino terminus of proteins. Bioconjug. Chem. 7:1996;38-44.
6. Lu B., et al. Oriented immobilization of antibodies and its applications to immunoassays and immunosensors. Analyst. 121:1996;29R-32R.
7. Vijayendran R.A., Leckband D.E. A quantitative assessment of heterogeneity for surface-immobilized proteins. Anal. Chem. 73:2001;471-480.
8. Fang Y. Membrane protein microarrays. JACS commun. 124:2002;2394-2395.
9. Lohrisch C., Piccart M. HER2/neu as a predictive factor in breast cancer. Clin. Breast Cancer. 2:2001;129-135.
10. Anderson L., Seilhammer J. A comparison of selected mRNA and protein abundances in human liver. Electrophoresis. 18:1997;533-537.
11. Masters C.L., Beyreuther K. Alzheimer's disease. Br. Med. J. 316:1998;446-448.
12. Jiang Q., Engelhardt J.F. Cellular heterogeneity of CFTR expression and function in the lung: implications for gene therapy of cystic fybrosis. Eur. J. Hum. Genet. 6:1998;12-31.
13. Joos T.O., et al. A microarray enzyme-linked immunosorbent assay for autoimmune diagnostics. Electrophoresis. 21:2001;2641-2650.
14. Ge, H. (2000) UPA, a universal protein array system for quantitative detection of protein-protein, protein-DNA, protein-RNA and protein-ligand interactions, Nucleic Acids Res. 28, e3 (i-vii)
15. Mendoza L.G., et al. High throughput microarray-based enzyme-linked immunosorbent assay (ELISA). Biotechniques. 27:1999;778-788.
16. Mooney J.F., et al. Patterning of functional antibodies and other proteins by photolithography of silane monolayers. Proc. Natl. Acad. Sci. U. S. A. 93:1996;12287-12291.
17. Jones V.W., et al. Microminiaturized immunoassays using atomic force microscopy and compositionally patterned antigen arrays. Anal. Chem. 70:1998;1233-1241.
18. Michael K.L., et al. Randomly ordered addressable high-density optical sensor arrays. Anal. Chem. 70:1998;1242-1248.
19. Ekins R.P. Ligand assays: from electrophoresis to miniaturized microarrays. Clin. Chem. 44:1998;2015-2030.
20. Buessow K., et al. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. Nucleic Acids Res. 26:1998;5007-5008.
21. Lueking A., et al. Protein microarrays for gene expression and antibody screening. Anal. Biochem. 270:1999;103-111.
22. Zhu H., et al. Global analysis of protein activities using proteome chips. Science. 293:2001;2101-2105.
23. Natsume T., et al. BIA-MS-MS: biomolecular interaction analysis for functional proteomics. Trends Biotechnol. 19:2001;28-33.
24. Weinberger S.R., et al. Recent trends in protein biochip technology. Pharmacogenomics. 1:2000;395-402.
25. Drews J. Drug discovery: a historical perspective. Science. 287:2000;1960-1964.
26. Rowe C.A., et al. An array immunosensor for simultaneous detection of clinical analytes. Anal. Chem. 71:1999;433-439.
27. Cohen C.B., et al. A microchip-based enzyme assay for protein kinase A. Anal. Biochem. 273:1999;89-97.
28. Arenkov P., et al. Protein microchips. Use for immunoassays and enzymatic reactions. Anal. Biochem. 278:2000;123-131.
29. Park C.B., Clark D.S. Sol-Gel encapsulated enzyme arrays for high-throughput screening of biocatalytic activity. Biotechnol. Bioeng. 78:2002;229-235.
30. Mangold U., et al. Identification and characterization of potential new therapeutic targets in inflammatory and autoimmune diseases. Eur. J. Biochem. 266:1999;1184-1191.
31. MacBeath G., et al. Printing small molecules as microarrays and detecting protein-ligand interactions en masse. J. Am Chem. Soc. 121:1999;7967-7968.
32. Haab B.B., et al. Protein microarrays for highly parallel detection and quantification of specific proteins and antibodies in complex solutions. Genome Biol. 2:2001;4.1-4.13.
33. Holt, L.J. et al. (2000) By-passing selection: Direct screening for antibody-antigen interactions using protein arrays, Nucleic Acids Res. 28, e72 (i-v)
34. Robinson H.R., et al. Autoantigen microarrays for multiplex characterization of autoantibody responses. Nat. Med. 8:2002;295-301.
35. Blackstock W.P. Proteomics: quantitative and physical mapping of cellular proteins. Trends Biotechnol. 17:1999;121-127.
36. Marshall T., et al. Proteomics and its impact upon biomedical science. Br. J. Biomed. Sci. 59:2002;47-64.
37. Muellner, S. The impact of proteomics in industrial processes and products. In Proteomics of microorganisms: Fundamental aspects and application (Hecker, M. and Mueller, S., eds), Springer Verlag (in press)
38. Gavin A-C., et al. Functional characterization of the yeast proteome by systematic analysis of protein complexes. Nature. 415:2002;141-147.