Interaction of oestrogen and peroxisome proliferator-activated receptors with apolipoprotein(a) gene enhancers

Biochemical Journal

Volumn 366, Issue 1, 2002, Pages 157-163

  Puckey, Loretto H ^a   Knight, Brian L ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Androgen; Gene transcription; Lipoprotein(a)

Indexed keywords

BIOASSAY; CARDIOLOGY; DISEASES; GENES;

CORONARY HEART DISEASE;

HORMONES;

ANDROGEN; APOLIPOPROTEIN A; DEOXYRIBONUCLEASE I; ESTROGEN; ESTROGEN RECEPTOR; HORMONE RECEPTOR; LIPOPROTEIN A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ARTICLE; CONCENTRATION RESPONSE; ELECTROPHORETIC MOBILITY; ENHANCER REGION; EXPRESSION VECTOR; GEL MOBILITY SHIFT ASSAY; GENE SEQUENCE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN INTERACTION; REPORTER GENE;

APOLIPOPROTEINS A; BASE SEQUENCE; BINDING, COMPETITIVE; CELL LINE; CELL NUCLEUS; CHROMATIN; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENHANCER ELEMENTS (GENETICS); ESTROGENS; GENES, REPORTER; GENETIC VECTORS; HUMANS; LIVER; MOLECULAR SEQUENCE DATA; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

VECTORS;

EID: 0037103727     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020293     Document Type: Article

References (39)

1. Lipoprotein(a). Heterogeneity and biological relevance
2. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations
3. The apolipoprotein(a) gene: A transcribed hypervariable locus controlling plasma lipoprotein(a) concentration
4. Genetic variation in lipoprotein(a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein(a) gene locus
5. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
6. A 2-Mb YAC contig linking the plasrninogen-apoprotein(a) gene family to the insulin-like growth factor 2 receptor (IGF2R) gene on the telomeric region of chromosome 6 (6q26-q27)
7. Molecular definition of the extreme size polymorphism in apolipoprotein(a)
8. Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma
9. Molecular basis for "null" lipoprotein(a) phenotypes and the influence of apolipoprotein(a) size on plasma lipoprotein(a) level in the baboon
10. Intracellular metabolism of human apolipoprotein(a) in stably transfected Hep G2 cells
11. Variation in lipoprotein(a) concentration associated with different apolipoprotein(a) alleles
12. Epidemiology of Lp(a) lipoprotein: Its role in atherosclerotic/thrombotic disease
13. Atherogenesis in transgenic mice expressing human apolipoprotein(a)
14. Detection and quantilication of lipoprotein(a) in the arterial wall of 107 coronary bypass patients
15. The apolipoprotein(a) gene is regulated by sex hormones and acute-phase inducers in YAC transgenic mice
16. Lipoprotein(a) concentrations in postmenopausal women taking norethisterone
17. Effects of tibolone on serum concentrations of lipoprotein(a) in postmenopausal women
18. Effect of postmenopausal hormone therapy on lipoprotein(a) concentration
19. Hormonal regulation of serum Lp(a) levels. Opposite effects after estrogen treatment and orchidectomy in males with prostatic carcinoma
20. Plasma lipoprotein(a) concentration is controlled by apolipoprotein(a) (apo(a)) protein size and the abundance of hepatic apo(a) mRNA in a cynomolgus monkey model
21. Detection and quantitation of apolipoprotein(a) mRNA in human liver and its relationship with plasma lipoprotein(a) concentration
22. Effects of estrus cycle, ovariectomy, and treatment with estrogen, tamoxifen, and progesterone on apolipoprotein(a) gene expression in transgenic mice
23. 5′ control regions of the apolipoprotein(a) gene and members of the related plasminogen gene family
24. Characterization by yeast artificial chromosome cloning of the linked apolipoprotein(a) and plasminogen genes and identification of the apolipoprotein(a) 5′ flanking region
25. Polymorphisms in the apolipoprotein(a) gene and their relationship to allele size and plasma lipoprotein(a) concentration
26. Characterization of multiple enhancer regions upstream of the apolipoprotein(a) gene
27. Several liver specific DNase hypersensitive sites are present in the intergenic region separating human plasminogen and apoprotein(a) genes
28. Estrogen modulation of apolipoprotein(a) expression. Identilication of a regulatory element
29. Mechanism of estrogen activation of c-myc oncogene expression
30. Delineation of sites mediating estrogen regulation of the rat creatine kinase B gene
31. Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells
32. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
33. The effect of peroxisome-proliferator-activated receptor-α on the activity of the cholesterol 7 α-hydroxylase gene
34. Reduction of lecithin-cholesterol acyltransferase, apolipoprotein D and the Lp(a) lipoprotein with the anabolic steroid stanazolol
35. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
36. Gemfibrozil significantly lowers cynomolgus monkey plasma lipoprotein[a]-protein and liver apolipoprotein[a] mRNA levels
37. Effect of gemfibrozil on levels of lipoprotein[a] in type II hyperlipoproteinemic subjects
38. Peroxisome proliferator-activated receptors: Structures and function
39. The nuclear receptor superfamily: The second decade