Synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (GLP-1)-stimulated insulin secretion and gene transcription in INS-1 cells: Characterization and implications

Biochemical Pharmacology

Volumn 64, Issue 4, 2002, Pages 689-697

  Kemp, Daniel M ^a,b   Habener, Joel F ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Dimethyl sulfoxide; GLP 1; Glucagon like peptide 1; INS 1; Insulin; Pancreatic cell

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; DIMETHYL SULFOXIDE; FORSKOLIN; GLUCAGON LIKE PEPTIDE 1; INSULIN; ISOBUTYLMETHYLXANTHINE; REGULATOR PROTEIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; CELL LINE; CONCENTRATION RESPONSE; CYCLIC AMP RESPONSIVE ELEMENT; DRUG POTENTIATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; INSULIN RELEASE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; RAT; REPORTER GENE; SIGNAL TRANSDUCTION;

ACTIVATING TRANSCRIPTION FACTOR 1; ANIMALS; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT MODULATOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIMETHYL SULFOXIDE; DNA-BINDING PROTEINS; DRUG SYNERGISM; GENE EXPRESSION; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; INSULIN; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN PRECURSORS; RATS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0037103455     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01212-1     Document Type: Article

References (28)

1. Nucleation and growth of ice crystals inside cultured hepatocytes during freezing in the presence of dimethyl sulfoxide
2. Synthesis of sialoglycoconjugates during dimethylsulfoxide-induced erythrodifferentiation of Friend leukemia cells
3. The appearance of phospholipase and cyclo-oxygenase activities in the human promyelocytic leukemia cell line HL60 during dimethyl sulfoxide-induced differentiation
4. Differentiation of beating cardiac muscle cells from a derivative of P19 embryonal carcinoma cells
5. Embryonic stem cells as a model for studying regulation of cellular differentiation
6. Discrete endogenous signals mediate neural competence and induction in P19 embryonal carcinoma stem cells
7. Effect of dimethyl sulfoxide (DMSO) on various experimental cutaneous reactions
8. Pharmacology of DMSO
9. Dimethyl sulphoxide: A review of its applications in cell biology
10. Glucagon-like peptides
11. The glucagon-like peptides
12. Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line
13. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)
14. Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells
15. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
16. Effects of dimethylsulfoxide on cyclic AMP accumulation, lipolysis and glucose metabolism of fat cells
17. Effect of dimethylsulfoxide on signal transduction in mutants of Saccharomyces cerevisiae
18. Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element
19. Distinct properties of the cAMP-responsive element of the rat insulin I gene
20. Gene-specific transcriptional activity of the insulin cAMP-responsive element is conferred by NF-Y in combination with cAMP response element-binding protein
21. Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression
22. Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines
23. Sodium butyrate increases glucagon and insulin gene expression by recruiting immunocytochemically negative cells to produce hormone
24. Transcriptional regulation of genes encoding insulin, glucagon, and angiotensinogen by sodium butyrate in a rat islet cell line
25. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
26. Factors that determine cell-specific gene expression in pancreatic endocrine tumor cells
27. Transmembrane signaling during erythropoietin- and dimethylsulfoxide-induced erythroid cell differentiation
28. Changes in G protein pattern and in G protein-dependent signaling during erythropoietin- and dimethylsulfoxide-induced differentiation of murine erythroleukemia cells