Effect of age on radiation-induced early changes of rat rectum. A histological time sequence

Radiotherapy and Oncology

Volumn 59, Issue 1, 2001, Pages 71-79

  Olofsen Van Acht, Manouk J J ^a   Van Hooije, Christel M C ^a   Van Den Aardweg, Gerard J M J ^a   Levendag, Peter C ^a   Van Velthuysen, Marie Louise F ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

Age; Histology; Radiation injury; Rat; Rectum

Indexed keywords

BROXURIDINE;

AGE; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL OCCLUSION; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HISTOPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; RADIATION HAZARD; RADIATION INJURY; RADIOSENSITIVITY; RAT; RECTUM ULCER; TOXICITY;

AGE FACTORS; ANALYSIS OF VARIANCE; ANIMALS; CULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; LOGISTIC MODELS; RADIATION DOSAGE; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, WISTAR; RECTUM; SENSITIVITY AND SPECIFICITY;

EID: 0035313736     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(01)00278-X     Document Type: Article

References (30)

1. Is curative radiation therapy in elderly patients limited by increased normal tissue toxicity?
2. Differential survival of murine small and large intestinal crypts following ionizing radiation
3. The number of clonogenic cells in crypts in three regions of murine large intestine
4. Pathology of idiopathic megarectum and megacolon
5. Late radiation injury of the small intestine. Clinical, pathophysiologic and radiobiologic aspects. A review
6. Colonic proliferation is increased in senescent rats
7. Small intestinal crypt cell proliferation rates are increased in senescent rats
8. Gynaecological cancer
9. Acute toxicity of curative radiotherapy in elderly patients
10. Cancer of the prostate
11. Epidemiology of cancer in the elderly
12. Effect of age on the radiation-induced repopulation in mouse lip mucosa
13. Influence of fraction size on the development of late radiation enteropathy
14. Optimal interfraction interval to minimize small bowel radiation injury in treatment regimens with two fractions per day: An experimental study in a rat model
15. Significance of overall treatment time for the development of radiation induced intestinal complications
16. Relationship between intestinal fibrosis and histopathologic and morphometric changes in consequential and late radiation enteropathy
17. Age dependency of response of the mouse skin to single and multifractionated gamma irradiation
18. Age-related changes in the cell kinetics of rat foot epidermis
19. Tolerance of rat rectum for radiation as a function of age
20. Chronic radiation enteritis: Its correlation with the elapsed time interval and morphological changes
21. Age is not a limiting factor for radical radiotherapy in pelvic malignancies
22. Age has no impact on acute and late toxicity of curative thoracic radiotherapy
23. Association of transforming growth factor β (TGF-β) immunoreactivity with specific histopathologic lesions in subacute and chronic experimental radiation enteropathy
24. Increased transforming growth factor β (TGF-β) immunoreactivity is independently associated with chronic injury in both consequential and primary radiation enteropathy
25. Radiotherapy in the elderly
26. Treatment outcome following radiotherapy in elderly patients with bladder cancer
27. Chronic damage after radiation therapy: Challenge to radiation biology
28. Experimental studies on the pathogenesis of the chronic radiation ulcer of the large bowel in rats
29. Reproducible rat model for comparing late rectal toxicity from different brachytherapy techniques
30. Radiotherapy for cancer patients aged 80 and older: A study of effectiveness and side effects