Signaling pathway for radiation-induced apoptosis in the lymphoblasts from neuronopathic (type A) and non-neuronopathic (type B) forms of Niemann-Pick disease

Journal of the Neurological Sciences

Volumn 199, Issue 1-2, 2002, Pages 39-43

  Mikami, Tamaki ^a   Takahashi, Tsutomu ^a   Ishida, Akira ^a   Minamiya, Yoshihiro ^a   Ida, Hiroyuki ^b   Takada, Goro ^a  

^a AKITA UNIVERSITY   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acid sphingomyelinase; Neuronopathic and non neuronopathic phenotypes; Radiation induced apoptosis

Indexed keywords

BISBENZIMIDE; DNA FRAGMENT; FLUOROCHROME; LYSOSOME ENZYME; SPHINGOMYELIN PHOSPHODIESTERASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CASE REPORT; CONTROLLED STUDY; DISEASE CLASSIFICATION; EPSTEIN BARR VIRUS; FEMALE; GENETIC HETEROGENEITY; GENOTYPE; HUMAN; HUMAN CELL; INCUBATION TIME; LYMPHOBLAST; MALE; NIEMANN PICK DISEASE; NONHUMAN; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; X IRRADIATION;

AMINO ACID SUBSTITUTION; ANIMALS; APOPTOSIS; CELL LINE, TRANSFORMED; CHILD, PRESCHOOL; CHLORPROMAZINE; COS CELLS; DNA FRAGMENTATION; DOPAMINE ANTAGONISTS; ENZYME ACTIVATION; FEMALE; HUMANS; LYMPHOCYTES; MALE; MUTATION; NIEMANN-PICK DISEASES; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 0037099785     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(02)00106-5     Document Type: Article

References (21)

1. Niemann-Pick disease types A and B: Acid sphingomyelelinase deficiencies
2. Accurate differentiation of neuronopathic and nonneuronopathic forms of Niemann-Pick disease by evaluation of the effective residual lysosomal sphingomyelinase activity in intact cells
3. Sphingomyelinase and Niemann-Pick disease
4. Sphingomyelin-cholesterol lipidoses: The Niemann-Pick group of diseases
5. Niemann-Pick disease
6. 3-induced HL-60 cell differentiation
7. Functions of ceramide in coordinating cellular responses to stress
8. Sphingomyelinase in cell regulation
9. The role of ceramide in cell signaling
10. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
11. Transitory type of sphingomyelinase defficient Niemann-Pick disease: Clinical and morphorogical studies and follow-up of two sisters
12. Identification of a missense mutation (S436R) in the acid sphingomyelinase gene from a Japanese patient with type B Niemann-Pick disease
13. Heterogeneity of liver disorder in type B Niemann-Pick disease
14. Purification of neutral sphingomyelinase from human urine
15. Identification and expression of five new mutations in the acid sphingomyelinase gene which cause type A and B Niemann-Pick disease. Molecular evidence for genetic heterogeneity in the neuronopathic and non-neuronopathic forms
16. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death
17. Acid sphingomyelinase deficient mice: A model of types A and B Niemann-Pick disease
18. Creation of a mouse model for non-neurological (type B) Niemann-Pick disease by stable, low level expression of lysosomal sphingomyelinase: Relationship between brain intra-lysosomal enzyme activity and central nervous system function
19. Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth
20. Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells
21. Lysosomal sphingomyelinase is not solicited for apoptosis signaling