Enhanced resistance of HeLa cells to cisplatin by overexpression of γ-glutamyltransferase

Biochemical Pharmacology

Volumn 64, Issue 2, 2002, Pages 207-216

  Daubeuf, Sandrine ^a   Leroy, Pierre ^a   Paolicchi, Aldo ^b   Pompella, Alfonso ^b   Wellman, Maria ^a   Galteau, Marie Madeleine ^a   Visvikis, Athanase ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Cisplatin resistance; GSH catabolism; Glutamyltransferase

Indexed keywords

CISPLATIN; CYSTEINE; CYSTEINYLGLYCINE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; REACTIVE OXYGEN METABOLITE;

ARTICLE; CANCER CELL CULTURE; CELL FUNCTION; CONTROLLED STUDY; CULTURE MEDIUM; DEFENSE MECHANISM; ENZYME INDUCTION; ENZYME SYNTHESIS; FEMALE; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; UTERINE CERVIX CARCINOMA;

ANTINEOPLASTIC AGENTS; CELL LINE; CELL SURVIVAL; CISPLATIN; DRUG RESISTANCE, NEOPLASM; GAMMA-GLUTAMYLTRANSFERASE; GLUTATHIONE; HELA CELLS; HUMANS; REACTIVE OXYGEN SPECIES;

EID: 0037099472     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01118-8     Document Type: Article

References (34)

1. The ATP-dependent glutathione S-conjugate export pump
2. High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis
3. Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells
4. Glutathione-associated cis-diamminedichloroplatinum(II) metabolism
5. Cisplatin generates superoxide anion by interaction with DNA in a cell-free system
6. Effect of glutathione on DNA repair in cisplatin-resistant human ovarian cancer cell lines
7. Cysteine control over glutathione homeostasis in chinese hamster fibroblasts overexpressing a γ-glutamylcysteine synthetase activity
8. Extracellular glutathione is a source of cysteine for cells that express gamma-glutamyl transpeptidase
9. Induction of γ-glutamyl transpeptidase mRNA by platinum complexes in a human ovarian carcinoma cell line
10. Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: Intrinsic differences and cell cycle effects
11. Association between expression of glutathione-associated enzymes and response to platinum-based chemotherapy in head and neck cancer
12. Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program
13. GGT: Nucleotide sequence of the human pancreatic cDNA
14. Differential regulation of γ-glutamyltransferase mRNAs in four human tumor cell lines
15. Measurement of plasma gamma-glutamyltransferase in clinical chemistry: Kinetic basis and standardisation propositions
16. Measurement of thiols in human plasma using liquid chromatography with precolumn derivatization and fluorescence detection
17. 2 in cultured endothelial cells
18. Characterization of cisplatin-glutathione adducts by liquid chromatography-mass spectrometry. Evidence for their formation in vitro but not in vivo after concomitant administration of cisplatin and glutathione to rats and cancer patients
19. Structure of the 5′ sequences of the human γ-glutamyltransferase gene
20. γ-Glutamyltransferase-dependent generation of reactive oxygen species from a glutathione/transferrin system
21. Decreased cisplatin uptake by resistant L1210 leukemia cells
22. Coordinated induction of MRP/GS-X pump and γ-glutamylcysteine synthetase by heavy metals in human leukemia cells
23. Cisplatin induction of ERRC-1 mRNA in A2780/CP70 human ovarian cancer cells
24. Mechanisms of resistance to cisplatin
25. Human ovarian tumors express γ-glutamyl transpeptidase
26. Gamma-glutamyl transpeptidase in normal and neoplastic prostate glands
27. γ-Glutamyl transpeptidase immunoreactivity in human neoplasia
28. Characterization of gamma-glutamylcysteine synthetase-heavy subunit promoter: A critical role for AP-1
29. Extracellular glutathione is a source of cysteine for cells that express gamma-glutamyl transpeptidase
30. Growth retardation and cysteine deficiency in γ-glutamyl transpeptidase-deficient mice
31. Effect of glutathione depletion on the cytotoxicity of cisplatin and iproplatin in a human melanoma cell line
32. Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion
33. Expression of gamma-glutamyl transpeptidase provides tumor cells with a selective growth advantage at physiologic concentrations of cyst(e)ine
34. 5-Fluorouracil and folinic acid using a weekly 24 hr infusion schedule for locally advanced head and neck cancer: A pharmacokinetic and clinical survey