Effect of glutathione depletion on the cytotoxicity of cisplatin and iproplatin in a human melanoma cell line

Cancer Chemotherapy and Pharmacology

Volumn 40, Issue 1, 1997, Pages 38-44

  Pendyala, L ^a   Perez, R ^a   Weinstein, A ^a   Zdanowicz, J ^a   Creaven, P J ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Cisplatin; Cytotoxicity; Glutathione; Iproplatin

Indexed keywords

BUTHIONINE SULFOXIMINE; CISPLATIN; GLUTATHIONE; IPROPLATIN; PLATINUM;

ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MELANOMA CELL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BUTHIONINE SULFOXIMINE; CELL SURVIVAL; CISPLATIN; GLUTATHIONE; HUMANS; MELANOMA; ORGANOPLATINUM COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 0030932344     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050622     Document Type: Article

References (39)

1. Ali-Osman F, Rairkar A (1992) Alterations in DNA polymerases α β and δ in human brain tumor cells after glutathione depletion. Proc Am Assoc Cancer Res 33:497
2. Andrews PA, Murphy MP, Howell SB (1989) Characterization of cisplatin resistance in COLO 316 human ovarian carcinoma cells. Eur J Cancer Clin Oncol 25:619
3. Bedford P, Walker MC, Sharma HL, Perera A, McAuliffe CA, Masters J, Hill BT (1987) Factors influencing the ,sensitivity of two human bladder carcinoma cell lines to cisdiamminedichloroplutinum(II). Chem Biol Interact 61:1
4. Behrens BC, Hamilton TC, Masuda H, Grotzinger KR, Whang-Peng J et al (1987) Characterization of a cis-diamminedichloroplatinum(II) resistant human ovarian cancer cell line and its use in evaluation of platinum analogues. Cancer Res 47:414
5. Bergelson S, Pinkus R, Daniel V (1994) Intracellular glutathione levels regulate fos/jun induction and activation of glutathione S-transferase gene expression. Cancer Res 54:36
6. Borch RF, Dedon PC, Gringeri A Montine TJ (1987) Inhibition of platinum drug toxicity by diethyldithiocarbamate. In: Nicolini M (ed) Platinum and other metal coordination compounds in cancer chemotherapy. Martinus Nijhoff, Boston, p 216
7. Chen G, Zeller WJ (1991) Augmentation of cisplatin cytotoxicity in vivo by DL-buthionine sulfoximine in DDP sensitive and resistant rat ovarian tumors and its relation to DNA interstrand cross links. Anticancer Res 11:2231
8. Deleve LD, Kaplowitz N (1991) Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther 52:287
9. Eastman A, Schulte N, Sheibani N, Sorenson CM (1987) Mechanisms of resistance to platinum drugs. In: Nicolini M (ed) Platinum and other metal coordination compounds in cancer chemotherapy. Martinus Nijhoff, Boston, p 178
10. Fahey RC, Newton GL (1987) Determination of low molecular weight thiols using monobromobimane fluorescent labelling and high performance liquid chromatography. Methods Enzymol 143:85
11. Fernandes RS, Cotter TG (1994) Apoptosis or necrosis: intracellular levels of glutathione influence mode of cell death. Biochem Pharmacol 48:675
12. Foster BJ, Hardy BJ, Wolpert-DeFillippes MK, Rubinstein LY, Clagett-Carr K, Leyland Jones B (1990) A strategy for the development of two clinically active cisplatin analogs: CBDCA and CHIP. Cancer Chemother Pharmacol 25:395
13. Godwin AK, Meister A, O'Dwyer PJ, Huang CS, Hamilton TC, Anderson ME (1992) High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc Natl Acad Sci USA 89:3070
14. Hosking LK, Whelan RDH, Shellard SA, Bedford P, Hill BT (1990) An evaluation of the role of glutathione and its associated enzymes in the expression of differential sensitivities to antitumour agents shown by a range of human tumour cell lines. Biochem Pharmacol 40: 1833
15. Hospers GA, Mulder NH, de Jong B, de Ley L, Uges DR, Fichtinger-Schepman AM, Scheper RJ, de Vries EG (1988) Characterization of a human small cell lung carcinoma cell line with acquired resistance to cisdiamminedichloroplatinum(II) in vitro. Cancer Res 48:6803
16. Hrubisko M, McGown AT, Fox BW (1993) The role of metallothionein, glutathione, glutathione S-transferases and DNA repair in resistance to platinum drugs in a series of L1210 cell nes made resistant to anticancer platinum agents. Biochem Pharmacol 45:253
17. Ishikawa T, Ali-Osman F (1993) Glutathione-associated cisdiamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. J Biol Chem 268:20116
18. Ishikawa T, Wright CD, Ishizuka H (1994) GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum(II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation. J Biol Chem 269:29085
19. Lai G, Ozols R, Young R, Hamilton T (1989) Effect of glutathione on DNA repair in cisplatin resistant human ovarian cancer cell lines. J Natl Cancer Inst 81:535
20. Lind MJ, McGown AT, Hadfield JA, Thatcher N, Crowther D, Fox BW (1989) The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo. Biochem Pharmacol 36:1835
21. Lira-Puerto V, Silva A, Morris M, Martinez R, Groshen S, Morales-Canfield F, Tenoris F, Muggia F (1991) Phase II trial of carboplatin or iproplatin in cervical cancer. Cancer Chemother Pharmacol 28:391
22. Lowry OH, Rosenbrough MT, Farr AL, Randall RJ (1951) Protein measurement with folin phenol reagent. J Biol Chem 193:265
23. Madajewicz S, Takita H, Creaven PJ, Bareniewski H, Regal A-M, Cushman K (1984) Phase II study of iproplatin (IPP) in small cell carcinoma of the lung (SCCL). Proc Am Soc Clin Oncol 3:224
24. McGahn MC, Tyczkowska K (1987) The determination of platinum in biological materials by electrochemical atomic absorption spectroscopy. Spectrachim Acta 42B:665
25. Meijer C, Mulder NH, Timmer-Bosscha H, Wluiter WJ, Meersma GJ, de Vries EGE (1992) Relationship of cellular glutathione to the cytotoxicity and resistance of seven platinum compounds. Cancer Res 52:6885
26. Meister A (1991) Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharmacol Ther 51:155
27. Mistry P, Kelland LR, Abel G, Sidhar S, Harrap KR (1991) The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines. Br J Cancer 64:215
28. Mistry P, Loh SY, Kelland LR, Harrap KR (1993) Effect of buthionine sulfoximine on PtII and PtIV drug accumulation and the formation of glutathione conjugates in human ovarian-carcinoma cell lines. Int J Cancer 55:848
29. Pendyala L, Cowens JW, Chheda G, Dutta S, Creaven PJ (1983) Identification of cis-dichloro-bis-isopropylamine platinum(II) as a major metabolite of iproplatin in humans. Cancer Res 48:3533
30. Pendyala L, Krishnan BS, Walsh JR, Arakali Av, Cowens JW, Creaven PJ (1989) Studies on the human metabolism of iproplatin. Cancer Chemother Pharmacol 25:10
31. Pendyala L, Arakali Av, Sansone P, Cowens JW, Creaven PJ (1990) DNA binding of iproplatin and its divalent metabolite cis-dichloro-bis-isopropylamine platinum(II). Cancer Chemother Pharmacol 27:248
32. Pendyala L, Creaven PJ, Perez R, Zdanowicz JR, Raghavan D (1995) Intracellular glutathione and cytotoxicity of platinum complexes. Cancer Chemother Pharmacol 36:271
33. Rairkar A, Ali-Osman F (1992) Modulation of DNA ligase activities in a BCNU and cisplatin resistant human malignant astrocytoma cell line by glutathione depletion. Proc Am Assoc Cancer Res 33:7
34. Richon VM, Schulte N, Eastman A (1987) Multiple mechanisms of cellular resistance to platinum coordination complexes. Cancer Res 47:2056
35. Robichaud NJ, Fram RJ (1990) Schedule dependence of buthionine sulfoximine in reversing resistance to cisplatin. Chem Biol Interact 76:333
36. Rubinstein LV, Shoemaker RH, Paull KD, Simon RM, Tosini S et al (1990) Comparison of in vitro anticancer drug screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J Natl Cancer Inst 82:1113
37. Smith E, Brock AP (1988) An in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effects of thiol depletion. Br J Cancer 57:548
38. Staal FJT, Roederer M, Herzenberg LA (1990) Intracellular thiols regulate activation of nuclear kB and transcription of human immunodeficiency virus. Proc Natl Acad Sci USA 87:9943
39. Staal JT, Anderson MT, Herzenberg LA (1995) Redox regulation of activation of NF-KB transcription factor complex: effects of N-acetylcysteine. Methods Enzymol 252:168