Reduction of lapachones and their reaction with L-cysteine and mercaptoethanol on glassy carbon electrodes

Bioelectrochemistry

Volumn 56, Issue 1-2, 2002, Pages 53-55

  Oliveira Brett, A M ^a   Goulart, M O F ^b   Abreu, F C ^a,b,c  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b FEDERAL UNIVERSITY OF ALAGOAS   (Brazil)

^c FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

Lapachone; Cytotoxic action; Electrochemical reduction; Topoisomerase

Indexed keywords

CYCLIC VOLTAMMETRY; ENZYMES; ETHANOL; GLASS; REDUCTION; SOLUTIONS;

DIFFERENTIAL PULSE VOLTAMMETRY;

ELECTROCHEMICAL ELECTRODES;

BETA LAPACHONE; CARBON; CYSTEINE; DNA TOPOISOMERASE; MERCAPTOETHANOL;

ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; CONFERENCE PAPER; DIFFERENTIAL PULSE VOLTAMMETRY; DRUG MECHANISM; ELECTROCHEMISTRY; ELECTRODE; REDUCTION;

ANIMALS; BIOSENSING TECHNIQUES; CARBON; CATTLE; CYSTEINE; DNA; ELECTRODES; MERCAPTOETHANOL; NAPHTHOQUINONES; OXIDATION-REDUCTION;

EID: 0037094147     PISSN: 15675394     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5394(02)00011-7     Document Type: Conference Paper

References (8)

1. Lomatiol: Part II. Its occurrence, constitution, relation to and conversion into lapachol. Also, a synthesis of lapachol
2. Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone
3. Induction of apoptosis by β-lapachone in human prostate cancer cells
4. Effect of β-lapachone on hydrogen peroxide production in Trypanosoma cruzi
5. Induction of DNA topoisomerase II-mediated DNA cleavage by β-lapachone and related naphthoquinones
6. Reaction of β-lapachone and related naphthoquinones with 2-mercaptoethanol: A biomimetic model of topoisomerase II poisoning by quinones
7. Reduction of lapachones in aqueous media at a glassy carbon electrode
8. Voltammetric behaviour of nitroimidazoles at a DNA-biosensor