Preparation and characterisation of attenuated cold-adapted influenza A reassortants derived from the A/Leningrad/134/17/57 donor strain

Vaccine

Volumn 20, Issue 16, 2002, Pages 2082-2090

  Wareing, M D ^a   Marsh, G A ^a   Tannock, G A ^a  

^a RMIT UNIVERSITY   (Australia)

Author keywords

Cold adapted; Influenza A; Live; Reassortants; Vaccine

Indexed keywords

INFLUENZA VACCINE; LIVE VACCINE; MEMBRANE ANTIGEN; VIRUS HEMAGGLUTININ; VIRUS SIALIDASE;

ANIMAL CELL; ANTIGEN DETECTION; ARTICLE; CELL CULTURE; CELL STRAIN; CONTROLLED STUDY; DRUG SYNTHESIS; GENE AMPLIFICATION; INFLUENZA VIRUS A; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGENY; RESTRICTION MAPPING; TEMPERATURE DEPENDENCE; TEMPERATURE SENSITIVITY; VIROGENESIS; VIRUS ATTENUATION; VIRUS GENE; VIRUS ISOLATION; VIRUS STRAIN;

ANIMALS; CELLS, CULTURED; CHICK EMBRYO; COLD; INFLUENZA A VIRUS; INFLUENZA VACCINES; PHENOTYPE; REASSORTANT VIRUSES; VACCINES, ATTENUATED;

EID: 0037093629     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(02)00056-7     Document Type: Article

References (32)

1. Studies on recombination with influenza viruses in the chick embryo. Part III. Reciprocal genetic interaction between two influenza virus strains
2. Recombinants of cold-adapted attenuated influenza A vaccines for use in children: Molecular and genetic analysis of the cold-adapted donor and recombinants
3. Evaluation of live attenuated influenza vaccines in children 6-18 months of age: Safety, immunogenicity, and efficacy
4. Hybrid formation of influenza virus at 25°
5. Comparative studies of wild-type and cold-mutant (temperature-sensitive) influenza viruses: Genealogy of the matrix (M) non-structural (NS) proteins in recombinant cold-adapted H3N2 viruses
6. Comparative studies of wild-type and cold-mutant (temperature-sensitive) influenza viruses: Nonrandom reassortment of genes during preparation of live virus vaccine candidates by recombination at 25°C between recent H3N2 and H1N1 epidemic strains and cold-adapted A/Ann Arbor/6/60
7. Laboratory properties of cold-adapted influenza B live vaccine strains developed in the US and USSR, and their B/Ann Arbor/1/86 cold-adapted reassortant vaccine candidates
8. Pilot studies on recombinant cold-adapted live type A and B influenza virus vaccines
9. PCR restriction analysis of genome composition and stability of cold-adapted reassortant live influenza vaccines
10. Genetic stability of cold-adapted A/Leningrad/134/47/57 (H2N2) influenza virus: Sequence analysis of live cold-adapted reassortant vaccine strains before and after replication in children
11. Gene analysis of reassortant influenza virus by RT-PCR followed by restriction enzyme digestion
12. Genetic instability of Russian cold-adapted live attenuated reassortant influenza vaccines
13. The immunogenicity of reassortants of the cold-adapted influenza A master strain A/Ann Arbor/6/60 is determined by both the genes for cold-adaptation and the haemagglutination gene
14. The relative immunogenicity of the cold-adapted influenza virus A/Ann Arbor/6/60 (A/AA/6/60-ca), recombinants of A/AA/6/60-ca and parental strains with similar surface antigens
15. Evaluation of chicken kidney and chicken embryo kidney cultures for the large-scale growth of attenuated influenza virus master strain A/Ann Arbor/6/60-ca
16. Comparison of neuraminidases of the same subtype but from different species using a new method of titration
17. Sequence changes in the live attenuated, cold-adapted variants of influenza A/Leningrad/134/57 (H2N2) virus
18. Intrinsic interference between influenza A and B viruses
19. Interference following dual inoculation with influenza A (H3N2) and (H1N1) viruses in ferrets and volunteers
20. Mechanism of interference between influenza A/WSN and B/Kanagawa viruses
21. Cold-adapted vaccine strains of influenza A virus act as dominant negative mutants in mixed infections with wild-type influenza A virus
22. Interference between cold-adapted (ca) influenza A and B vaccine reassortants or between ca reassortants and wild-type strains in eggs and mice
23. Dominance of cold-adapted influenza A virus over wild-type viruses is at the level of RNA synthesis
24. The genes associated with trans-dominance of the influenza A cold-adapted live virus vaccine
25. Properties of influenza virus cold recombinants
26. Rescue of influenza A virus from recombinant DNA
27. Generation of influenza A viruses entirely from cloned cDNAs
28. Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cells
29. Hyperattenuated recombinant influenza A virus nonstructural-protein-encoding vectors induce human immunodeficiency virus type 1 Nef-specific systemic and mucosal immune responses in mice
30. Advantage of live attenuated cold-adapted influenza A virus over inactivated vaccine for A/Washington/80 (H3N2) wild-type virus infection
31. Genetically engineered live attenuated influenza A virus vaccine candidates