Cancer-related thrombotic microangiopathy secondary to Von Willebrand factor-cleaving protease deficiency

Thrombosis Research

Volumn 106, Issue 2, 2002, Pages 127-130

  Blot, Emmanuel ^a,c   Decaudin, Didier ^a   Veyradier, Agnès ^b   Bardier, Armelle ^a   Zagame, Odette Lyvia ^a   Pouillart, Pierre ^a  

^a INSTITUT CURIE   (France)

^b BICÊTRE HOSPITAL   (France)

^c CENTRE HENRI BECQUEREL   (France)

Author keywords

Cancer; Metastasis; Protease; Thrombotic microangiopathy; Von Willebrand factor

Indexed keywords

CA 19-9 ANTIGEN; CORTICOSTEROID DERIVATIVE; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; ENZYME ANTIBODY; IFOSFAMIDE; PROTEINASE; VON WILLEBRAND FACTOR;

ADULT; ANEMIA; ANTIBODY DETECTION; ARTICLE; CANCER; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CASE REPORT; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME DEGRADATION; FEMALE; HEMOLYSIS; HUMAN; LABORATORY TEST; METASTASIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; THROMBOCYTE AGGREGATION; THROMBOCYTOPENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA;

ADAM PROTEINS; ADENOCARCINOMA; ANEMIA, HEMOLYTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CA-19-9 ANTIGEN; COMBINED MODALITY THERAPY; CYCLOPHOSPHAMIDE; DACARBAZINE; DOXORUBICIN; ESOPHAGEAL NEOPLASMS; FATAL OUTCOME; FEMALE; HUMANS; IFOSFAMIDE; JAUNDICE; METALLOENDOPEPTIDASES; MIDDLE AGED; NEOPLASMS, MULTIPLE PRIMARY; NEOPLASMS, RADIATION-INDUCED; NEOPLASMS, SECOND PRIMARY; PARANEOPLASTIC SYNDROMES; SARCOMA; THROMBOCYTOPENIA; TUMOR MARKERS, BIOLOGICAL; VON WILLEBRAND FACTOR;

EID: 0037089066     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(02)00095-6     Document Type: Article

References (13)

1. Antman K.H., Skarin A.T., Mayer R.J., Hargreaves H.K., Canellos G.P. Microangiopathic hemolytic anemia and cancer: a review. Medicine (Baltimore). 58:1979;377-384.
2. Snyder H.W., Mittelman A., Oral A., Messerschmidt G.L., Henry D.H., Korec S.et al. Treatment of cancer chemotherapy-associated thrombotic thrombocytopenic purpura/hemolytic uremic syndrome by protein A immunoadsorption of plasma. Cancer. 71:1993;1882-1892.
3. Furlan M., Robles R., Galbusera M., Remuzzi G., Kyrle P.A., Brenner B.et al. Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. N. Engl. J. Med. 339:1998;1578-1584.
4. Tsai H.M., Lian E.C. Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura. N. Engl. J. Med. 339:1998;1585-1594.
5. Oleksowicz L., Bhagwati N., DeLeon-Fernandez M. Deficient activity of von Willebrand's factor-cleaving protease in patients with disseminated malignancies. Cancer Res. 59:1999;2244-2250.
6. Obert B., Tout H., Veyradier A., Fressinaud E., Meyer D., Girma J.P. Estimation of the von Willebrand factor-cleaving protease in plasma using monoclonal antibodies to vWF. Thromb. Haemost. 82:1999;1382-1385.
7. Blot E., Marie I., Delastre O., Cailleux N., Pouillart P., Levesque H.et al. La microangiopathie thrombotique associée au cancer est une urgence carcinologique: à propos d'un cas. Rev. Med. Interne. 20:1999;448-449.
8. Furlan M. Von Willebrand factor: molecular size and functional activity. Ann. Hematol. 72:1996;341-348.
9. Furlan M., Robles R., Lamie B. Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis. Blood. 87:1996;4223-4234.
10. Moake J.L., Rudy C.K., Troll J.H., Weinstein M.J., Colannino N.M., Azocar J.et al. Unusually large plasma factor VIII: von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura. N. Engl. J. Med. 307:1982;1432-1435.
11. Oleksowicz L., Bhagwati N., Fernandez M.D., Seno R., Etkind P. Prognostic significance of platelet immunorelated GPIb expression in breast cancer. Cancer J. Sci. Am. 4:1998;247-253.
12. Oleksowicz L., Dutcher J.P., DeLeon-Fernandez M., Paietta E., Etkind P. Human breast carcinoma cells synthesize a protein immunorelated to platelet glycoprotein-Ib alpha with different functional properties. J. Lab. Clin. Med. 129:1997;337-346.
13. Burke G.W., Ciancio G., Cirocco R., Markou M., Olson L., Contreras N.et al. Microangiopathy in kidney and simultaneous pancreas/kidney recipients treated with tacrolimus: evidence of endothelin and cytokine involvement. Transplantation. 68:1999;1336-1342.