Monoamine depletion in unmedicated depressed subjects

Biological Psychiatry

Volumn 51, Issue 6, 2002, Pages 469-473

  Berman, Robert M ^a,b,f   Sanacora, Gerard ^a,b,c,d   Anand, Amit ^c,d   Roach, Lisa M ^a,b,c   Fasula, Madonna K ^a,b   Finkelstein, Catherine O ^a,b   Wachen, R Mathew ^a,b   Oren, Dan A ^a,b,c   Heninger, George R ^a,b,d   Charney, Dennis S ^e  

^a Yale University School of Medicine   (United States)

^b Affective Disorders Program   (United States)

^c VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^f PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Alpha methly para tyrosine; Catecholamine; Indoleamine; Major depression; Tryptophan depletion

Indexed keywords

CATECHOLAMINE; DIPHENHYDRAMINE; INDOLEAMINE; METIROSINE; MONOAMINE; TRYPTOPHAN;

ADULT; ARTICLE; CASE REPORT; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; FEMALE; HUMAN; MALE; MOOD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN FUNCTION; REGULATORY MECHANISM;

ADULT; ALPHA-METHYLTYROSINE; CATECHOLAMINES; DEPRESSIVE DISORDER, MAJOR; DIPHENHYDRAMINE; DOPAMINE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; NOREPINEPHRINE; PERSONALITY INVENTORY; SEROTONIN; TRYPTOPHAN;

EID: 0037087266     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(01)01285-9     Document Type: Article

References (26)

1. Serotonergic 'vulnerability' in affective disorder: A study of the tryptophan depletion test and relationships between peripheral and central serotonin indexes in citalopram-responders
2. Functional interrelationship of serotonin and norepinephrine: Cortisol response to MCPP and DMI in patients with panic disorder, patients with depression, and normal control subjects
3. Mechanism of action of antidepressants: Monoamine hypotheses and beyond
4. Transient depressive relapse induced by catecholamine depletion: Potential phenotypic vulnerability marker?
5. Catecholamines and mania: The effect of alpha-methyl-para-tyrosine on manic behavior and catecholamine metabolism
6. Norepinephrine in depressive reactions: A review
7. Tryptophan depletion during continuous CSF sampling in healthy human subjects
8. The biochemistry of affective disorders
9. Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan
10. Monoamines and the mechanism of antidepressant action: Effects of catecholamine depletion on mood of patients treated with antidepressants
11. Serotonin and the neurobiology of depression. Effects of tryptophan depletion in drug-free depressed patients
12. Biochemical and pharmacologic effects of alpha-methyltyrosine in man
13. Potentiation of monoamine oxidase inhibitor by tryptophan
14. Effects of tryptophan depletion on responses to yohimbine in healthy human subjects
15. The revised monoamine theory of depression: A modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans
16. Intensification of the central serotonergic processes as a possible determinant of thymoleptic effect
17. Effects on mood of acute phenylalanine/tyrosine depletion in healthy women
18. Sleep deprivation and impaired cognition. Possible role of brain catecholamines
19. Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression
20. Effects of alpha-methyl-para-tyrosine (AMPT) in drug-free depressed patients
21. The serotonergic and noradrenergic systems of the hippocampus: Their interactions and the effects of antidepressant treatments
22. Rapid tryptophan depletion, sleep electroencephalogram, and mood in men with remitted depression on serotonin reuptake inhibitors
23. Effects of tranylcypromine treatment on neuroendocrine, behavioral, and autonomic responses to tryptophan in depressed patients
24. Lack of behavioral effects of monoamine depletion in heathy subjects
25. Effects of acute tryptophan depletion on plasma and cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in normal volunteers
26. Inhibition of presynaptic catecholamine synthesis with alpha-methyl-para-tyrosine attenuates nocturnal melatonin secretion in humans