Lack of behavorial effects of monoamine depletion in healthy subjects

Biological Psychiatry

Volumn 41, Issue 1, 1997, Pages 58-64

  Salomon, Ronald M ^a   Miller, Helen L ^a   Krystal, John H ^a   Heninger, George R ^a   Charney, Dennis S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMPT; behavior; catecholamine; dopamine; indoleamine; norpinephrine

Indexed keywords

CATECHOLAMINE; METIROSINE; MONOAMINE; TRYPTOPHAN; AMINO ACID; ENZYME INHIBITOR; TYROSINE 3 MONOOXYGENASE;

ADULT; ARTICLE; BEHAVIOR; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MOOD; NORMAL HUMAN; PRIORITY JOURNAL; AFFECT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ANTAGONISM; DRUG EFFECT; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; ADULT; AFFECT; ALPHA-METHYLTYROSINE; AMINO ACIDS; CATECHOLAMINES; DOUBLE-BLIND METHOD; ENZYME INHIBITORS; FEMALE; HUMANS; MALE; METHYLTYROSINES; MIDDLE AGED; TRYPTOPHAN; TYROSINE 3-MONOOXYGENASE;

EID: 0030614328     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-3223(95)00670-2     Document Type: Article

References (26)

1. Bacopoulous NG, Redmond DE, Roth RH (1979): Serotonin and dopamine metabolites in brain regions and cerebrospinal fluid of a primate species: Effects of ketamine and fluphenazine. J Neurochem 32:1215-1218.
2. Benkelfat C, Ellenbogen MA, Dean P, Palmour RM, Young SN (1994): Mood lowering effect of tryptophan depletion. Arch Gen Psychiatry 51:687-697.
3. Brodie HKH, Murphy DL, Goodwin FK, Bunney WE (1971): Catecholamines and mania: The effect of alpha-methyl-para-tyrosine on manic behavior and catecholamine metabolism. Clin Pharmacol Exp Ther 12:218-224.
4. Bunney WE, Davis JM (1965): Norepinephrine in depressive reactions. Arch Gen Psychiatry 13:483-494.
5. Bunney WE, Brodie HK, Murphy DL, Goodwin FK (1971): Studies of alpha-methyl-para-tyrosine, L-dopa, and L-tryptophan in depression and mania. Am J Psychiatry 127:872-881.
6. Charney DS, Delgado PL (1992): Current concepts of serotonin neuronal function and the pathophysiology of depression. In Elliott M, Heal DJ, Marsden CA (eds), Experimental Approaches to Anxiety and Depression. London: Wiley, pp 197-218.
7. Coppen A (1967): The biochemistry of affective disorders. Br J Psychiatry 113:1237-1264.
8. Delgado PL, Price LH, Miller HL, et al (1991): Rapid serotonin depletion as a provocative challenge test for patients with major depression: Relevance to antidepressant action and the neurobiology of depression. Psychopharmacol Bull 27:321-330.
9. Delgado PL, Miller HL, Salomon RM, et al (1993): Monoamines and the mechanism of antidepressant action: Effects of catecholamine depletion on mood of patients treated with antidepressants. Psychopharmacol Bull 29:389-396.
10. Delgado PL, Price LJ, Miller JL, Salomon RM, Heninger GH, Charney DS (1994): Serotonin and the neurobiology of depression: Effects of tryptophan depletion in drug-free depressed patients. Arch Gen Psychiatry 51:865-874.
11. Heninger GR, Charney DS (1987): Mechanism of action of antidepressant treatments: Implications for the etiology and treatment of depressive disorders. In Meltzer HY (ed), Psychopharmacology, A Generation of Progress. New York: Raven Press, pp 535-554.
12. Heslop K, Portas CM, Curzon G (1991): Effect of altered tryptophan availability on tissue and extracellular serotonin in rat cortex. In Rollema J, Westerink B, Drijshout WJ (eds), Monitoring Molecules in Neuroscience. Mepple, The Netherlands: Krits Repro, pp 259-261.
13. Kapur S, Mann JJ (1992): Role of the dopaminergic system in depression. Biol Psychiatry 32:1-17.
14. Maas JW, Hattox SE, Landis DH, Roth RH (1976): The determination of a brain arteriovenous difference for 3-methoxy-4-hydroxyphenelethylene glycol (MHPG). Brain Res 118:167-173.
15. Mazure CM, Nelson JC, Price LH (1986): Reliability and validity of the symptoms of major depressive illness. Arch Gen Psychiatry 43:451-456.
16. McCann UD, Penetar DM, Shaham Y, et al (1993): Effects of catecholamine depletion on alertness and mood in rested and normal volunteers. Neuropsychopharmacology 8:345-356.
17. McCann UD, Thorne D, Hall M, et al (1995): The Effects of L-dihydroxyphenylalanine on alertness and mood in α-methyl-para-tyrosine-treated healthy humans: Further evidence for the role of catecholamines in arousal and anxiety. Neuropsychopharmacology 13:41-52.
18. McNair DM, Lorr M, Droppleman LF (1988): Manual for the Profile of Mood States. San Diego, CA: Educational and Industrial Testing Service.
19. Miller HL, Delgado PL, Salomon RM, Heninger GR, Charney DS (1996): Effects of alpha-meta-para-tyrosine (AMPT) in drug-free depressed patients. Neuropsychopharmacology 14: 151-157.
20. Miller HL, Delgado PL, Salomon RM, et al (in press b): The behavioral effects of catecholamine depletion on antidepressant induced remission of depression: Implications for monoamine hypothesis of antidepressant action. Arch Gen Psychiatry 53:117-128.
21. Nagatsu T, Levitt M, Udenfriend S (1964): Tyrosine hydroxylase, the initial step in norepinephrine biosynthesis. J Biol Chem 239:2910-2917.
22. Rech RH, Borys HK, Moore KE (1966): Alterations in behavior and brain catecholamine levels in rats treated with alpha-methyl-para-tyrosine. J Pharmacol Exp Ther 153:412-419.
23. Schatzberg AF, Schildkraut JJ (1995): Recent studies on norepinephrine systems in mood disorders. In Bloom FE, Kupfer DJ (eds), Psychopharmacology: The Fourth Generation of Progress. New York: Raven Press, pp 911-920.
24. Spector S, Sjoerdsma A, Udenfriend S (1965): Blockade of endogenous norepinephrine synthesis by alpha-methyl-para-tyrosine, an inhibitor of tyrosine hydroxylase. J Pharmacol Exp Ther 147:86-95.
25. Spitzer RL, Williams JBW, Gibbon M, First MB (1990): Structured Clinical Interview for DSM-III-R, nonpatient edition (SCID-NP, version 1.0). Washington, DC: American Psychiatric Press.
26. Young SN, Ervin FR, Pihl RO (1989): Biochemical aspects of tryptophan depletion in primates. Psychopharmacology 98: 508-511.