Characterization and isolation of enzymes that hydrolyze short-chain acyl-CoA in rat-liver mitochondria

European Journal of Biochemistry

Volumn 239, Issue 2, 1996, Pages 526-531

  Svensson, L Thomas ^a   Kilpeläinen, Seppo H ^b   Hiltunen, J Kalervo ^b   Alexson, Stefan E H ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF OULU   (Finland)

Author keywords

acyl CoA hydrolase; Intermediate metabolism; Peroxisome proliferators; Rat liver; Subcellular organelles

Indexed keywords

PALMITOYL COENZYME A HYDROLASE; PEROXISOME PROLIFERATOR;

ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ISOLATION; HYDROLYSIS; IMMUNOPRECIPITATION; LIVER MITOCHONDRION; MALE; METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0030036294     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0526u.x     Document Type: Article

References (31)

1. Prass, R. L., Isohashi, F. & Utter, M. F. (1980) Purification and characterization of an extramitochondrial acetyl coenzyme A hydrolase from rat liver, J. Biol. Chem. 255, 5215-5223.
2. Lee, F.-J. S., Lin, L.-W. & Smith, J. A. (1989) Purification and characterization of an acetyl-CoA hydrolase from Saccaromyces cerevisiae, Eur. J. Biochem. 184, 21-28.
3. Lee, F. J., Lin, L. W. & Smith, J. A. (1990) A glucose-repressible gene encodes acetyl-CoA hydrolase from Saccharomyces cerevisiae, J. Biol. Chem. 265, 7413-7418.
4. Robinson, J. J., Mahan, D. E. & Koeppe, R. E. (1976) Studies on rat brain acyl-coenzyme A hydrolase (short chain), Biochem. Biophys. Res. Commun. 71, 959-965.
5. Bernson, S. M. (1976) Acetyl-CoA hydrolase: activity, regulation and physiological significance of the enzyme in brown adipose tissue from hamster, Eur. J. Biochem. 67, 403-410.
6. Alexson, S. E. H. & Nedergaard, J. (1988) A novel type of short-and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria, J. Biol. Chem. 263, 13564-13571.
7. Alexson, S. E. H., Svensson, L. T. & Nedergaard, J. (1989) NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat, Biochim. Biophys. Acta 1005, 13-19.
8. Osmundsen, H., Neat, C. E. & Borrebaek, B. (1980) Fatty acid products of peroxisomal β-oxidation, Int. J. Biochem. 12, 625-630.
9. Alexson, S. E. H., Osmundsen, H. & Berge, R. K. (1989) The presence of acyl-CoA hydrolase in rat brown-adipose-tissue peroxisomes, Biochem. J. 262, 41-46.
10. Hovik, R., Brodal, B., Bartlett, K. & Osmundsen, H. (1991) Metabolism of acetyl-CoA by isolated peroxisomal fractions: formation of acetate and acetoacetyl-CoA. J. Lipid Res. 32, 993-999.
11. Wilcke, M. & Alexson, S. E. H. (1994) Characterization of acyl-CoA thioesterase activity in isolated rat liver peroxisomes. Partial purification and characterization of a long-chain acyl-CoA thioesterase, Eur. J. Biochem. 222, 803-811.
12. Knowles, S. E., Jarrett, I. G., Filsell, O. H. & Ballard, F. J. (1974) Production and utilization of acetate in mammals, Biochem. J. 142, 401-411.
13. Snoswell, A. M. & Tubbs, P. K. (1978) Deacylation of acetyl-coenzyme A and acetylcarnitine by liver preparations, Biochem. J. 171, 299-303.
14. Grigat, K. P., Koppe, K., Seufert, C. D. & Söling, H. D. (1979) Acetyl-coenzyme A deacylase activity in liver is not an artifact. Subcellular distribution and substrate specificity of acetyl-coenzyme A deacylase activities in rat liver, Biochem. J. 177, 71-79.
15. Aragon, J. J. & Lowenstein, H. M. (1983) A survey of enzymes wich generate or use acetoacetyl thioesters in rat liver, J. Biol. Chem. 258, 4725-4733.
16. Lazarow, P. B. & De Duve, C. (1976) A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug, Proc. Natl Acad. Sci. USA 73, 2043-2046.
17. Mannaerts, G. P., Thomas, J., Debeer, L. J., McGarry, J. D. & Foster, D. W. (1978) Hepatic fatty acid oxidation and ketogenesis after clofibrate treatment, Biochim. Biophys. Acta 529, 201-211.
18. Mannaerts, G. P., Debeer, L. J., Thomas, J. & Schepper De, P. (1979) Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibratetreated rats, J. Biol. Chem. 254, 4585-4595.
19. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein/dye binding, Anal. Biochem. 72, 248-254.
20. Laemmli, U. K. (1970) Cleavage of structural proteins during assembly of the head of bacteriophage T4, Nature 227, 680-685.
21. Fukao, T., Kamijo, K., Osumi, T., Fujiki, Y., Yamaguchi, S., Orii, T. & Hashimoto, T. (1989) Molecular cloning and nucleotide sequence of cDNA encoding the entire precursor of rat mitochondrial acetoacetyl-CoA thiolase, J. Biochem. (Tokyo) 106, 197-204.
22. Brady, P. S., Scofield, R. F., Ohgaku, S., Schumann, W. C., Bartsch, G. E., Margolis, J. M., Kumaran, K., Horvat, A., Mann, S. & Landau, B. R. (1982) Pathways of acetoacetate's formation in liver and kidney, J. Biol. Chem. 257, 9290-9293.
23. Rodriguez, J. C., Gil-Gomez, G., Hegardt, F. G. & Haro, D. (1994) Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids, J. Biol. Chem. 269, 18767-18772.
24. Ashmarina, L. I., Rusnak, N., Miziorko, H. M. & Mitchell, G. A. (1994) 3-Hydroxy-3-methylglutaryl-CoA lyase is present in mouse and human liver peroxisomes, J. Biol. Chem. 269, 31929-31932.
25. Hayashi, H. & Miwa, A. (1989) The role of peroxisomal fatty acyl-CoA β-oxidation in bile acid biosynthesis, Arch. Biochem. Biophys. 274, 582-589.
26. Horie, S., Suzuki, T. & Suga, T. (1989) Existence of acetyl-CoA-dependent chain elongation system in hepatic peroxisomes of rat: effects of clofibrate and di-(2-ethylhexyl)phthalate on the activity, Arch. Biochem. Biophys. 274, 64-73.
27. Leighton, F., Bergseth, S., Rørtveit, T., Christiansen, E. N. & Bremer, J. (1989) Free acetate production by rat hepatocytes during peroxisomal fatty acid and dicarboxylic acid oxidation, J. Biol. Chem. 264, 10347-10350.
28. Hovik, R., Brodal, B., Bartlett, K. & Osmundsen, H. (1991) Metabolism of acetyl-CoA by isolated peroxisomal fractions: formation of acetate and acetoacetyl-CoA, J. Lipid Res. 32, 993-999.
29. Nakanishi, Y., Okamoto, K. & Isohashi, F. (1994) Subcellular distribution of ATP-stimulated and ADP-inhibited acetyl-CoA hydrolase in livers from control and clofibrate-treated rats: comparison of the cytosolic and peroxisomal enzyme, J. Biochem. (Tokyo) 115, 328-332.
30. Gergely, J., Hele, P. & Ramakrishnan, C. V. (1952) Succinyl and acetyl coenzyme A deacylases, J. Biol. Chem. 198, 323-335.
31. Söling, H.-D. & Rescher, C. (1985) On the regulation of cold-labile cytosolic and of mitichondrial acetyl-CoA hydrolase in rat liver, Eur. J. Biochem. 147, 111-117.