Targeted deletion of the MLC1f/3f downstream enhancer results in precocious MLC expression and mesoderm ablation

Developmental Biology

Volumn 243, Issue 2, 2002, Pages 281-293

  Jiang, Ping ^a,b   Song, Jihwan ^a,c   Gu, Guoqing ^a,d   Slonimsky, Esfir ^a   Li, En ^a   Rosenthal, Nadia ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Advanced Cell Technology   (United States)

^c HARVARD UNIVERSITY   (United States)

^d CHA University   (South Korea)

Author keywords

Enhancer; Mouse development; Myosin

Indexed keywords

CONTRACTILE PROTEIN; MYOSIN LIGHT CHAIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MOTILITY; CELL PROLIFERATION; CELL STRUCTURE; EMBRYO DEVELOPMENT; GENE DELETION; GENE EXPRESSION; GENE LOCUS; IN SITU HYBRIDIZATION; MESODERM; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

MUS MUSCULUS;

EID: 0037086320     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2002.0574     Document Type: Article

References (55)

1. Stopped at the border: Boundaries and insulators
2. The neuron-restrictive silencer element: A dual enhancer/silencer crucial for patterned expression of a nicotinic receptor gene in the brain
3. Going the distance: A current view of enhancer action
4. Molecular mechanisms of nonmuscle myosin-II regulation
5. An E box comprises a positional sensor for regional differences in skeletal muscle gene expression and methylation
6. Regulatory light chain mutations affect myosin motor function and kinetics
7. Targeted disruption of the Dictyostelium RMLC gene produces cells defective in cytokinesis and development
8. Effects of light chain phosphorylation and skeletal myosin on the stability of non-muscle myosin filaments
9. Regulation of non-muscle myosin structure and function
10. Identification of a class of chromatin boundary elements
11. A muscle-specific enhancer is located at the 3′ end of the myosin light-chain 1/3 gene locus
12. Mammalian muscle cells bear a cell-autonomous, heritable memory of their rostrocaudal position
13. Drosophila nonmuscle myosin II has multiple essential roles in imaginal disc and egg chamber morphogenesis
14. Targeted deletion of 5′HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus
15. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
16. DNA position-specific repression of transcription by a Drosophila zinc finger protein
17. A transgene target for positional regulators marks early rostrocaudal specification of myogenic lineages
18. Role of methylation in maintenance of positionally restricted transgene expression in developing muscle
19. The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse
20. A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans
21. Wis mutant embryos
22. Forced expression of essential myosin light chain isoforms demonstrates their role in smooth muscle force production
23. Transgenic over-expression of a motor protein at high levels results in severe cardiac pathology
24. Myf-5 revisited: Loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice
25. Myosin light chain 3F regulatory sequences confer regionalized cardiac and skeletal muscle expression in transgenic mice
26. Embryonic and fetal myogenic programs act through separate enhancers at the MLC1F/3F locus
27. A position-effect assay for boundaries of higher order chromosomal domains
28. Myosins of nonmuscle cells
29. An enhancer deletion affects both H19 and Igf2 expression
30. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
31. The expression of regulation of myosin genes in developing skeletal muscle in the mouse embryo
32. Myosin II function in non-muscle cells
33. Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus
34. Homeobox genes and muscle patterning
35. Know your neighbors: Three phenotypes in null mutants of the myogenic bHLH gene MRF4
36. Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing
37. A genetically engineered, protein-based optical biosensor of myosin II regulatory light chain phosphorylation
38. A single locus in the mouse encodes both myosin light chains 1 and 3, a second locus corresponds to a related pseudogene
39. Myosin light chain enhancer activates muscle-specific, developmentally regulated gene expression in transgenic mice
40. A highly conserved enhancer downstream of the human MLC1/3 locus is a target for multiple myogenic determination factors
41. Chimeric myosin regulatory light chains identify the subdomain responsible for regulatory function
42. A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer
43. Structure-function analysis of the motor domain of myosin
44. Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2
45. Regulation of cytoplasmic and smooth muscle myosin
46. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice
47. Myosin light chain phosphorylation in vertebrate striated muscle: Regulation and function
48. Coupling of ATPase activity and motility in smooth muscle myosin is mediated by the regulatory light chain
49. Myosin structure and function in cell motility
50. Drosophila nonmuscle myosin II is required for rapid cytoplasmic transport during oogenesis and for axial nuclear migration in early embryos
51. Expression pattern of the mouse T gene and its role in mesoderm formation
52. Transvection, nuclear structure, and chromatin proteins
53. Double replacement: Strategy for efficient introduction of subtle mutations into the murine Colla-1 gene by homologous recombination in embryonic stem cells
54. Visualization of chromosomal domains with boundary element-associated factor BEAF-32