Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor

Proteins: Structure, Function and Genetics

Volumn 46, Issue 3, 2002, Pages 340-342

  Min, Kyeongsik ^a   Song, Hyun Kyu ^a   Chang, Changsoo ^a   Kim, Sun Young ^b   Lee, Kong Joo ^b   Suh, Se Won ^a  

^a Seoul National University   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOSIDE DIPHOSPHATE KINASE;

COMPLEX FORMATION; CONFERENCE PAPER; CRYSTAL STRUCTURE; CRYSTALLIZATION; DNA BINDING; ELECTRICITY; ENZYME ANALYSIS; ENZYME STRUCTURE; HUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY ANALYSIS;

CRYSTALLOGRAPHY, X-RAY; HUMANS; NEOPLASM METASTASIS; NUCLEOSIDE-DIPHOSPHATE KINASE;

EID: 0037083393     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10038     Document Type: Conference Paper

References (8)

1. Nm23/nucleoside diphosphate kinase: Toward a structural and biochemical understanding of its biological functions
2. Crystallization and preliminary X-ray crystallographic analysis of human nucleoside diphosphate kinase A
3. X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 Å resolution
4. The crystal structure of a human nucleoside diphosphate kinase, NM23-H2
5. Site-directed mutagenesis of Nm23-H1: Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells
6. Two-component kinase-like activity of nm23 correlates with its motility- suppressing activity
7. A nucleoside diphosphate kinase A (nm23-H1) serine 120 → glycine substitution in advanced stage neuroblastoma affects enzyme stability and alters protein-protein interaction
8. A Pro/Ser substitution in nucleoside diphosphate kinase of Drosophila melanogaster (mutation killer of prune) affects stability but not catalytic efficiency of the enzyme