New efficient pathway for the synthesis of 3-aminoestrone

Tetrahedron Letters

Volumn 43, Issue 42, 2002, Pages 7617-7619

  Radu, Ioan Iosif ^a   Poirier, Donald ^a   Provencher, Louis ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

3 aminoestrone; Amination; Aminosteroids; Girard reagent; Steroids

Indexed keywords

3 AMINOESTRONE; AMMONIA; BENZOPHENONE DERIVATIVE; ESTRONE DERIVATIVE; ESTRONE TRIFLATE; PALLADIUM; STEROID; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; CATALYSIS; CATALYST; DRUG PURITY; DRUG SYNTHESIS; TEMPERATURE;

EID: 0037078353     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(02)01823-3     Document Type: Article

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30. 4, filtered, and concentrated under reduced pressure. The compound was then purified on silica gel by flash chromatography and eluted with hexanes:EtOAc/5:1 to provide 14 mg (87% yield) of compound 3 (aminoestrone).
31. Characteristics of 3-aminoestrone identical to those reported in the literature (Ref. 11).