Glutathione, albumin, cysteine, and cys-gly effects on toxicity and accumulation of mercuric chloride in llc-pk1 cells

Journal of Toxicology and Environmental Health - Part A

Volumn 57, Issue 7, 1999, Pages 489-505

  Divine, Kevin K ^a,b   Ayala Fierro, Felix ^a   Barber, David S ^a,c   Carter, Dean E ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^c VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ANION; CYSTEINE; GLUTATHIONE; GLYCINE; LIGAND; MERCURIC CHLORIDE; THIOL DERIVATIVE; THIOL GROUP;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; KIDNEY; MEMBRANE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; TARGET ORGAN;

ALBUMINS; ANIMALS; CELLS, CULTURED; CYSTEINE; DIPEPTIDES; ENVIRONMENTAL POLLUTANTS; GLUTATHIONE; KIDNEY; LLC-PK1 CELLS; MERCURIC CHLORIDE; SULFHYDRYL COMPOUNDS; SWINE;

EID: 0033551897     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/009841099157566     Document Type: Article

References (30)

1. Agency for Toxic Substances and Disease Registry. 1994. Toxicological Profile for Mercury. U.S. Department of Health and Human Services, ATSDR. Atlanta, GA.
2. Aleo, M. D., Taub, M. L., and Kostyniak, P. J. 1992. Primary cultures of rabbit renal proximal tubule cells. Toxicol. Appl. Pharmacol.112:310-317.
3. Baggett, J. M., and Berndt, W. O. 1986. The effect of depletion of nonprotein sulfhydryl by diethyl maleate plus butathione sulfoximine on renal uptake of mercury In the rat. Toxicol. Appl. Pharmacol.83:556-562.
4. Ballatori, N. 1991. Mechanisms of metal transport across liver cell plasma membranes. Drug Metab. Rev.23:83-132.
5. Berlin, M. 1986. Mercury. In Handbook on the toxicology of metals, vol. 2, Specific metals, 2nd ed., eds. L. Friberg, G. F. Nordberg, and V. B. Vouk, pp. 387-445. New York: Elsevier.
6. Berndt, W. O., Baggett, J. M., Blacker, A., and Houser, M. 1985. Renal glutathione and mercury uptake by the kidney. Fundam. Appl. Toxicol.5:832-839.
7. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem.72:248-254.
8. Brown, J. R., and Shockley, P. 1982. Serum albumin: structure and characterization of its ligand binding sites. In Lipid-protein interactions, eds. P. C. Jost and O. H. Griffith, pp. 25-68. New York: Wiley.
9. de Ceaurriz, J., Payan, J. P., and Brondeau, M. T. 1994. Role of extracellular glutathione and y-gluta-myltranspeptidase in the disposition and kidney toxicity of inorganic mercury in rats. J. Appl. Toxicol.14:201-206.
10. Endo, T., Sakata, M., and Shaikh, Z. A. 1995. Mercury uptake by primary cultures of rat renal cortical epithelial cells. II. Effects of pH, halide i ons, and alkali metal ions. Toxicol. Appl. Pharmacol.134: 321-325.
11. Fitzgerald, W. F., and Clarkson, T. W. 1991. Mercury and monomethylmercury: Present and future concerns. Environ. Health Perspect.96:159-166.
12. Girardi, G., and Elias, M. M. 1991. Effectiveness of N-acetylcysteine in protecting against mercury chloride-induced nephrotoxicity. Toxicology67:155-164.
13. Girardi, G., and Elias, M. M. 1993. Effect of different renal glutathione l evels on renal mercury disposition and excretion in the rat. Toxicology81:57-67.
14. Jocelyn, P. C. 1972. Biochemistry of the SH group.London: Academic Press.
15. Johnson, D. R. 1982. Role of renal cortical sulfhydryl groups in development of mercury-induced renal toxicity. J. Toxicol. Environ. Health9:119-126.
16. 1 cells. Toxicol. Appl. Pharmacol.137:301-306.
17. May, P. M., Linder, P. W., and Williams, D. R. 1977. Computer simulation of metal-ion equilibria in biofluids: Models for the low-molecular-weight complex distribution of calcium(II), mag-nesium(II), manganese(II), iron(III), copper(II), zinc(II), and lead(II) ions in human blood plasma. J. Chem. Soc. Dalton Trans.6:588-595.
18. Oram, P. D., Fang, X., Fernando, Q., Letkeman, P., and Letkeman, D. 1996. The formation constants of the mercury(II)-glutathione complexes. Chem. Res. Toxicol.9:709-712.
19. 1) with characteristics of proximal tubular cells. Am. J. Physiol.250:F734-F743.
20. Roehm, N. W., Rodgers, G. H., Hafield, S. M., and Glasebrook, A. L. 1991. An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT. J. Immunol. Methods142:257-265.
21. Tanaka, T., Naganuma, A., and Imura, N. 1990. Role of y-glutamyltranspeptidase in renal uptake and toxicity of inorganic mercury in mice. Toxicology60:187-198.
22. Tanaka-Kagawa, T., Naganuma, A., and Imura, N. 1992. Tubular secretion and reabsorption of mercury compounds in mouse kidney. J. Pharmacol. Exp. Ther.264:776-782.
23. Zalups, R. K. 1995. Organic anion transport and action of y-glutamyl transpeptidase in kidney linked mechanistically to renal tubular uptake of inorganic mercury. Toxicol. Appl. Pharmacol.132: 289-298.
24. Zalups, R. K., and Barfuss, D. W. 1993. Intrarenal distribution of inorganic mercury and albumin after coadministration. J. Toxicol. Environ. Health40:77-103.
25. Zalups, R. K., and Barfuss, D. W. 1995a. Accumulation and handling of inorganic mercury in the kidney after coadministration with glutathione. J. Toxicol. Environ. Health44:385-399.
26. Zalups, R. K., and Barfuss, D. W. 1995b. Pretreatment with p-aminohippurate inhibits the renal uptake and accumulation of injected i norganic mercury in the rat. Toxicology103:23-35.
27. Zalups, R. K., and Barfuss, D. W. 1996. Nephrotoxicity of inorganic mercury co-administered with L-cysteine. Toxicology109:15-29.
28. Zalups, R. K., and Lash, L. H. 1994. Advances in understanding the renal transport and toxicity of mercury. J. Toxicol. Environ. Health42:1-44.
29. Zalups, R. K., and Minor, K. H. 1995. Luminal and basolateral mechanisms involved in the renal tubular uptake of inorganic mercury. J. Toxicol. Environ. Health46:73-100.
30. Zheng, W., Maiorino, R. M., Brendel, K., and Aposhian, H. V. 1990. Determination and metabolism of dithiol chelating agents VII. Biliary excretion of dithiols and their interaction with cadmium and metallothionein. Fundam. Appl. Toxicol.14:598-607.