Extract screening by HPLC coupled to MS-MS, NMR, and CD: A dimeric and three monomeric naphthylisoquinoline alkaloids from Ancistrocladus griffithii

Phytochemistry

Volumn 61, Issue 2, 2002, Pages 195-204

  Bringmann, Gerhard ^a   Wohlfarth, Michael ^a   Rischer, Heiko ^a   Schlauer, Jan ^a   Brun, Reto ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

Ancistrocladaceae; Ancistrocladus griffithii; Ancistrogriffine A; Ancistrogriffine B; Ancistrogriffine C; Ancistrogriffithine A; Antimalarial activity; Hyphenated analysis; Isolation; Online structure elucidation

Indexed keywords

ALKALOID; ANCISTROGRIFFINE A; ANCISTROGRIFFINE B; ANCISTROGRIFFINE C; ANCISTROGRIFFITHINE A; ANTILEISHMANIAL AGENT; ANTIMALARIAL AGENT; ANTIPROTOZOAL AGENT; DIMER; ISOQUINOLINE ALKALOID; MONOMER; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANCISTROCLADUS GRIFFITHII; ANGIOSPERM; ANIMAL; ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LEISHMANIA DONOVANI; MASS SPECTROMETRY; MEDICINAL PLANT; METHODOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ONLINE ANALYSIS; PHYTOCHEMISTRY; PLASMODIUM FALCIPARUM; RELIABILITY; STRUCTURE ANALYSIS; TRYPANOSOMA; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE;

ALKALOIDS; ANGIOSPERMS; ANIMAL; ANTIPROTOZOAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; LEISHMANIA DONOVANI; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PLANT EXTRACTS; PLASMODIUM FALCIPARUM; SPECTRUM ANALYSIS, MASS; SUPPORT, NON-U.S. GOV'T; TRYPANOSOMA; ANIMALS; MASS SPECTROMETRY;

ANCISTROCLADACEAE; ANCISTROCLADUS; LEISHMANIA DONOVANI; PLASMODIUM FALCIPARUM;

EID: 0037072498     PISSN: 00319422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9422(02)00217-0     Document Type: Article

References (42)

1. Liquid chromatography-nuclear magnetic resonance spectroscopy
2. Cultivation in a semi-defined medium of animal infective forms of Trypartosoma brucei, T. equiperdum, T. evansi, T. rhodensiense, and T. gambiense
3. Anti-HIV michellamines from Ancistrocladus korupensis
4. Novel antiparasitic biaryl alkaloids from Westafrican Dioncophyllaceae plants
5. The alkaloids of Triphyophyllum peltatum (Dioncophyllaceae)
6. An improved degradation procedure for determination of the absolute configuration in chiral isoquinoline and β-carboline derivatives
7. First total synthesis of the 7,6′-coupled antifungal naphthylisoquinoline alkaloid dioncophylline B
8. HPLC-NMR on-line coupling including the ROESY technique: Direct characterization of naphthylisoquinoline alkaloids in crude plant extracts
9. Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis
10. Determination of configuration at the biaryl axes of naphthylisoquinoline alkaloids by long-range NOE effects
11. Ancistroheynine A, the first 7,8′-coupled naphthylisoquinoline alkaloid from Ancistrocladus heyneanus
12. HPLC-CD on-line coupling in combination with HPLC-NMR and HPLC-MS/MS for the determination of the full absolute stereostructure of new metabolites in plant extracts
13. The naphthylisoquinoline alkaloids
14. Ancistrocladus, eine botanisch und chemisch bemerkenswerte gattung
15. Use of on-line high-performance liquid chromatography-nuclear magnetic resonance spectrometry coupling in phytochemical screening studies: Rapid identification of metabolites in Dioncophyllum thollonii
16. 1H NMR spectroscopy
17. Jozimine A ('dimeric' dioncophylline A), a non-natural michellamine analog with high antimalarial activity
18. Murrastifoline-F: First synthesis, atropo-enantiomer resolution, and stereoanalysis of an axially chiral N,C-coupled biaryl alkaloid
19. Ancistrobertsonines B, C, and D as well as 1,2-didehydro-ancistrobertsonine D from Ancistrocladus robertxoniorum
20. Ancistrobertsonine A and related naphthylisoquinoline alkaloids from Ancistrocladus robertsoniorum
21. A photometric screening method for dimeric naphthylisoquinoline alkaloids and complete on-line structural elucidation of a dimer in crude plant extracts, by the LC-MS/LC-NMR/LC-CD triad
22. A new biosynthetic pathway to alkaloids in plants: Acetogenic isoquinolines
23. The absolute configuration of michellamine B, a "dimeric", anti-HIV-active naphthylisoquinoline alkaloid
24. Ethnobotany and drug discovery: The experience of the US National Cancer Institute
25. Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection
26. Quantitative assessment of antimalarial acitvity in vitro by a semi-automated microdilution technique
27. Differential sensitivity of erythrocytic stages of the rodent malaria parasite Plasmodium chabaudi chabaudi to dioncophylline B, a highly active naphthylisoquinoline alkaloid
28. Naphthylisoquinoline alkaloids against malaria: Evaluation of the curative potential of dioncophylline C and dioncopeltine A against Plasmodium berghei in vivo
29. Typification of names in Ancistrocladus Wall. (Ancistrocladaceae)
30. Ancistrocladine, a new type of isoquinoline alkaloid from Ancistrocladus heyneanus
31. Hamatine, a new isoquinoline alkaloid from Ancistrocladus hamatus (Vahl)
32. Korundamine A, a novel HIV-inhibitory and antimalarial "hybrid" naphthylisoquinoline alkaloid heterodimer from Ancistrocladus korupensis
33. Korupensamines A-D, novel antimalarial alkaloids from Ancistroclacladus korupensis
34. Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis
35. Application of directly coupled HPLC-NMR-MS to the identification and confirmation of quercetin glycosides and phloretin glycosides in apple peel
36. Essai monographique d'une nouvelle famille de plantes proposee sous le nom d'ancistrocladacees
37. The alamar blue assay to determine drug sensitivity of African trypanosomes(T. b. rhodensiense and T. gambiense) in vitro
38. 4-Aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodiun falciparum
39. Characterization of enzymes from Ancistrocladus (Ancistrocladaceae) and Triphyophyllum (Dioncophyllaceae) catalyzing oxidative coupling of naphthylisoquinoline alkaloids to give michellamines
40. Michellamine alkaloids inhibit protein kinase C
41. Antioxidant activity of michellamine alkaloids
42. Liquid chromatography, coupled to mass spectrometry and nuclear magnetic resonance spectroscopy for the screening of plant constituents